Direct Meds vs Live Vital
In our scoring, Live Vital edges ahead overall (7.7 vs 6.4 out of 10), and Live Vital costs less for compounded semaglutide (about $2,004 a year less).
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Key differences
- Price
- Live Vital $130/mo vs Direct Meds $297/mo for compounded semaglutide (standing prices, no prepay or separate membership listed · about $2,004 a year less with Live Vital)
- Coverage
- Live Vital 50 states (Direct Meds doesn't publish a state list)
- Included
- Direct Meds: medication, clinician visits, shipping; Live Vital: medication, clinician visits, shipping
- Safety
- FDA warning letters on record: Direct Meds 1, Live Vital none
Direct Meds
Affiliate partnerAlso prices oral compounded semaglutide and oral compounded tirzepatide
semaglutide
$297
Our score 6.4/10
Live Vital
Affiliate partnerBest for low-cost, physician-led compounded GLP-1 with peptide and hormone options
semaglutide
$130
$99 first month
Our score 7.7/10
We may earn a commission if you sign up through these links. Partner status can affect which provider we feature; it never changes a score or a price.
Costs & coverage
Published prices with their terms attached. Yearly figures are modeled from the standing price and billing cadence. A check mark marks the better side, on like-for-like rows only.
Direct Meds
Live Vital
Price
Semaglutide / month
$297/mo
Better on this row: $130/mo
$99 first month
Semaglutide / year (modeled)
$3,564
Better on this row: $1,560
Tirzepatide / month
$399/mo
Better on this row: $239/mo
$183 first month
Tirzepatide / year (modeled)
$4,788
Better on this row: $2,868
Oral semaglutide / month
$249/mo
Not listed
Oral tirzepatide / month
$299/mo
Not listed
Coverage
State availability
List not published
50 states
Oral option listed
Yes
Not listed
Included in the price
Medication, clinician visits, shipping
Medication, clinician visits, shipping
Terms & safety
Price shown
Before intake
Before intake
Lab work
Not disclosed
Not required
Video visit
Not disclosed
Not required
Cancel anytime
No
Better on this row: Yes
Minimum commitment
3-month prepay
Sold as 10-week protocols
Refunds
Not disclosed
Terms section 7: 'You may cancel at any time. Cancellation will be effective at the end of your current billing period. Refunds for consultations are provided at our discretion. Medications and lab work are generally non-refundable once ordered or dispensed.'
Early-cancellation fee
Yes
Not disclosed
FDA warning letters
1 warning letter
Better on this row: None on record
Provider facts checked
August 2026
August 2026
Every dose and plan: Direct Meds · Live Vital
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Which fits your priorities?
Only the points where these two differ, from the table above and each provider’s record.
Choose Direct Meds if…
- Lists oral compounded semaglutide and oral compounded tirzepatide, which Live Vital doesn't price
- All-inclusive pricing covers medication, consultations, supplies, and 1–2 day temperature-controlled shipping
- LegitScript Certified
What to weigh up
- 1 FDA warning letter on record
- About $2,004 a year more than Live Vital for compounded semaglutide
Choose Live Vital if…
- About $2,004 a year less than Direct Meds for compounded semaglutide at standing prices
- Publishes its full state list (50 states)
- Cancel anytime
What to weigh up
- The advertised '/mo' rate divides a 10-week protocol by three, so a calendar month really costs about $130 or $239
- Doesn't accept insurance (HSA/FSA funds only)
Explore the scoring factors
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Direct Meds
6.4/10
Live Vital
7.7/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
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Direct Meds vs Live Vital: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
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