Direct Meds vs Enhance MD
In our scoring, Enhance MD edges ahead overall (8.2 vs 6.4 out of 10), and Enhance MD costs less for compounded semaglutide (about $1,020 a year less).
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Key differences
- Price
- Enhance MD $212/mo vs Direct Meds $297/mo for compounded semaglutide (standing prices, no prepay or separate membership listed · about $1,020 a year less with Enhance MD)
- Coverage
- Enhance MD 39 states (Direct Meds doesn't publish a state list)
- Included
- Direct Meds: medication, clinician visits, shipping; Enhance MD: medication, clinician visits, labs
- Safety
- FDA warning letters on record: Direct Meds 1, Enhance MD none
Direct Meds
Affiliate partnerAlso prices oral compounded semaglutide and oral compounded tirzepatide
semaglutide
$297
Our score 6.4/10
Enhance MD
Affiliate partnerBest for lab-monitored compounded GLP-1 with mandatory video visit
semaglutide
$212
$112 first month
Our score 8.2/10
We may earn a commission if you sign up through these links. Partner status can affect which provider we feature; it never changes a score or a price.
Costs & coverage
Published prices with their terms attached. Yearly figures are modeled from the standing price and billing cadence. A check mark marks the better side, on like-for-like rows only.
Direct Meds
Enhance MD
Price
Semaglutide / month
$297/mo
Better on this row: $212/mo
$112 first month
Semaglutide / year (modeled)
$3,564
Better on this row: $2,544
Tirzepatide / month
$399/mo
Better on this row: $169/mo
Tirzepatide / year (modeled)
$4,788
Better on this row: $2,028
Oral semaglutide / month
$249/mo
Not listed
Oral tirzepatide / month
$299/mo
Not listed
Coverage
State availability
List not published
39 states
Oral option listed
Yes
Not listed
Included in the price
Medication, clinician visits, shipping
Medication, clinician visits, labs
Terms & safety
Price shown
Before intake
Before intake
Lab work
Not disclosed
Required
Video visit
Not disclosed
Required
Cancel anytime
No
Better on this row: Yes
Minimum commitment
3-month prepay
None
Early-cancellation fee
Yes
Not disclosed
FDA warning letters
1 warning letter
Better on this row: None on record
Provider facts checked
August 2026
August 2026
Every dose and plan: Direct Meds · Enhance MD
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Which fits your priorities?
Only the points where these two differ, from the table above and each provider’s record.
Choose Direct Meds if…
- Lists oral compounded semaglutide and oral compounded tirzepatide, which Enhance MD doesn't price
- All-inclusive pricing covers medication, consultations, supplies, and 1–2 day temperature-controlled shipping
- LegitScript Certified
What to weigh up
- 1 FDA warning letter on record
- About $1,020 a year more than Enhance MD for compounded semaglutide
Choose Enhance MD if…
- About $1,020 a year less than Direct Meds for compounded semaglutide at standing prices
- Publishes its full state list (39 states)
- Cancel anytime
What to weigh up
- Not available in 10 states: AL, AR, GA, HI, LA, MS, MO, SC, TN, WV
- Mandatory lab work adds 5–10 days to onboarding vs async-only competitors
Explore the scoring factors
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Direct Meds
6.4/10
Enhance MD
8.2/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
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Direct Meds vs Enhance MD: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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