Amazon One Medical vs Rx.com
An in-depth comparison of two leading GLP-1 Providers
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Amazon One Medical
Best for: the most authoritative brand-name GLP-1 channel, with same-day delivery
Visit Amazon One Medical →
Rx.com
Best for: month-to-month compounded GLP-1s at one flat price per dose, with the pharmacy named
Visit Rx.com →Amazon One Medical and Rx.com are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, Amazon One Medical starts lower at $149/mo versus $175/mo, and Amazon One Medical edges ahead overall (8.5 vs 7.6 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
Amazon One Medical
Rx.com
'1 month $175 per month'. Longer plans are one upfront charge: 3 months $495 ($165/mo), 6 months $875 ($146/mo). Checkout fine print says billing continues every 28 days.
'1 month $285 per month'. Longer plans are one upfront charge: 3 months $795 ($265/mo), 6 months $1,550 ($259/mo). Checkout fine print says billing continues every 28 days.
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What’s included
Amazon One Medical
What the monthly price covers
Medication
Billed separately
Provider visits
Included
Shipping
Included
Lab work
Billed separately
Coaching
Not disclosed
Rx.com
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Amazon One Medical
8.5/10
Rx.com
7.6/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | Amazon One Medical | Rx.com |
|---|---|---|
| Starting Price | ✓$149/mo | $175/mo |
| Features | 6 features | ✓8 features |
| States Available | ✓50 | 49 |
| Compounded | — | ✓ Yes |
| Brand Name | ✓ Yes | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About Amazon One Medical
Amazon One Medical is the unified Amazon GLP-1 channel — One Medical clinicians prescribe FDA-approved Wegovy, Zepbound, and Foundayo (no compounded products), and Amazon Pharmacy fulfills with same-day delivery across roughly 3,000 US cities plus pickup kiosks at select One Medical locations. No prior membership required; insurance and cash pay both accepted. Foundayo launched at $25/month with insurance and the Lilly Savings Card, or $149/month cash pay.
Read our full Amazon One Medical review →About Rx.com
Rx.com, a San Antonio-based prescription-savings and online-care site, now runs its own GLP-1 program: compounded semaglutide at $175/mo or tirzepatide at $285/mo on a one-month plan, with lower monthly rates on three- and six-month plans paid upfront. One price covers the provider visit, medication at any dose, supplies and shipping. Care comes through the MD Integrations provider network, and Manifest Pharmacy in South Carolina fills prescriptions.
Read our full Rx.com review →Pros & Cons
Amazon One Medical
What we like
- As low as $1/day ($25/month) for brand-name Foundayo with insurance and the auto-applied Lilly coupon
- Same-day delivery in nearly 3,000 US cities at launch, expanding to 4,500 by end of 2026
- In-office pharmacist kiosks at select One Medical clinics let you walk out with Foundayo in hand
- Cash-pay $5/day ($149/month) is competitive for the same FDA-approved brand-name product
- Real-time availability, transparent pricing, and automatic manufacturer coupon at checkout
- Delivering GLP-1 medications since 2021 — track record on cold-chain logistics
Watch-outs
- Headline $25/month needs both insurance and the Lilly Savings Card — uninsured pay $149/month
- Same-day delivery is geographically gated; outside major cities it drops to next-day or slower
- Pricing is set by manufacturer savings programs and can change at any time
- No compounded options — brand-name only (Foundayo, Wegovy, Zepbound)
- Wegovy/Zepbound pricing isn't shown upfront — depends on insurance at the prescribing visit
- Copays and deductibles still apply to the clinical visit
Rx.com
What we like
- Prices are posted before any intake: semaglutide $175/mo and tirzepatide $285/mo month to month, the same at every dose
- Names its dispensing pharmacy (Manifest Pharmacy, Greer, SC) and its provider network (MD Integrations)
- One price covers the provider visit, follow-ups, medication, syringes, alcohol pads and shipping
- No membership, visit, dose-upcharge or shipping fees
- Six-month plans lower the rate to $146/mo for semaglutide and $259/mo for tirzepatide, paid as one charge
- Full refund if the provider decides treatment is not right for you
- Displays a LegitScript seal served from LegitScript's own servers, not a self-hosted image
- Serves 49 states; Alaska is the only state turned away
Watch-outs
- Plan pages promise 'No automatic renewals,' but the checkout fine print says billing continues every 28 days
- On six-month plans that checkout text reads as if the full $875 or $1,550 repeats monthly, an apparent template error
- A second program page still lists older prices ($179.99 first month, then $279.99/mo) that don't match the plan picker
- Medication sales are final once shipped, and no policy covers unshipped months if you cancel a prepaid plan
- No phone number is published, though checkout promises '24/7 support via email or phone'
- The refund policy says Rx.com does not ship refrigerated products, while the program promises cold-packed shipping
- New program with almost no outside review history: its Trustpilot profile has a single review
- Compounded semaglutide and tirzepatide are not FDA-approved
Our Verdict
Amazon One Medical edges out Rx.com with a higher overall score of 8.5/10 and is particularly strong for the most authoritative brand-name GLP-1 channel, with same-day delivery. Rx.com remains a solid alternative, especially if you're looking for month-to-month compounded GLP-1s at one flat price per dose, with the pharmacy named.
Choose Amazon One Medical if…
You want the most authoritative brand-name GLP-1 channel, with same-day delivery and a starting price around $149/mo.
Choose Rx.com if…
You want month-to-month compounded GLP-1s at one flat price per dose, with the pharmacy named and a starting price around $175/mo.
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Get started →Amazon One Medical vs Rx.com: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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