Rx.com vs Vytora Health
An in-depth comparison of two leading GLP-1 Providers
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Rx.com
Best for: month-to-month compounded GLP-1s at one flat price per dose, with the pharmacy named
Visit Rx.com →
Vytora Health
Best for: compounded or brand-name GLP-1 with named pharmacy partners, 50 states
Visit Vytora Health →Rx.com and Vytora Health are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, Vytora Health starts lower at $150/mo versus $175/mo, and Vytora Health edges ahead overall (8.4 vs 7.6 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
Rx.com
'1 month $175 per month'. Longer plans are one upfront charge: 3 months $495 ($165/mo), 6 months $875 ($146/mo). Checkout fine print says billing continues every 28 days.
'1 month $285 per month'. Longer plans are one upfront charge: 3 months $795 ($265/mo), 6 months $1,550 ($259/mo). Checkout fine print says billing continues every 28 days.
Vytora Health
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What’s included
Rx.com
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Vytora Health
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Rx.com
7.6/10
Vytora Health
8.4/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | Rx.com | Vytora Health |
|---|---|---|
| Starting Price | $175/mo | ✓$150/mo |
| Features | 8 features | 8 features |
| States Available | 49 | ✓51 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | ✓ Yes |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About Rx.com
Rx.com, a San Antonio-based prescription-savings and online-care site, now runs its own GLP-1 program: compounded semaglutide at $175/mo or tirzepatide at $285/mo on a one-month plan, with lower monthly rates on three- and six-month plans paid upfront. One price covers the provider visit, medication at any dose, supplies and shipping. Care comes through the MD Integrations provider network, and Manifest Pharmacy in South Carolina fills prescriptions.
Read our full Rx.com review →About Vytora Health
Vytora Health is a 50-state-plus-DC telehealth platform offering compounded semaglutide and tirzepatide alongside brand-name Mounjaro and Zepbound, plus NAD+ and sermorelin peptides. It names its pharmacy partners publicly — Vials Pharmacy and Greenwich Biosciences — and discloses its operating physician group, uncommon transparency for the category. Compounded semaglutide runs $180/mo ($150 on a 3-month bundle) and tirzepatide $249/mo ($200 bundled).
Read our full Vytora Health review →Pros & Cons
Rx.com
What we like
- Prices are posted before any intake: semaglutide $175/mo and tirzepatide $285/mo month to month, the same at every dose
- Names its dispensing pharmacy (Manifest Pharmacy, Greer, SC) and its provider network (MD Integrations)
- One price covers the provider visit, follow-ups, medication, syringes, alcohol pads and shipping
- No membership, visit, dose-upcharge or shipping fees
- Six-month plans lower the rate to $146/mo for semaglutide and $259/mo for tirzepatide, paid as one charge
- Full refund if the provider decides treatment is not right for you
- Displays a LegitScript seal served from LegitScript's own servers, not a self-hosted image
- Serves 49 states; Alaska is the only state turned away
Watch-outs
- Plan pages promise 'No automatic renewals,' but the checkout fine print says billing continues every 28 days
- On six-month plans that checkout text reads as if the full $875 or $1,550 repeats monthly, an apparent template error
- A second program page still lists older prices ($179.99 first month, then $279.99/mo) that don't match the plan picker
- Medication sales are final once shipped, and no policy covers unshipped months if you cancel a prepaid plan
- No phone number is published, though checkout promises '24/7 support via email or phone'
- The refund policy says Rx.com does not ship refrigerated products, while the program promises cold-packed shipping
- New program with almost no outside review history: its Trustpilot profile has a single review
- Compounded semaglutide and tirzepatide are not FDA-approved
Vytora Health
What we like
- All 50 states plus DC, with per-state video-vs-audio compliance disclosed
- Both compounded and brand-name options on one platform — uncommon
- LegitScript Approved and HIPAA compliant
- Pharmacy partners named publicly: Vials Pharmacy (TX) and Greenwich Biosciences
- Operating entity disclosed: Wasef Health, PC (Pinellas Park, FL)
- Competitive monthly pricing ($180 sema / $249 tirz) plus a 3-month bundle saving 17%
- Brand-name Mounjaro and Zepbound available at $1,399/mo for FDA-approved options
Watch-outs
- Brand-name Mounjaro/Zepbound at $1,399/mo is near retail — insured patients may do better via LillyDirect Self Pay ($449-$699/mo)
- Compounded tirzepatide at $249/mo is mid-market, above the $149-199 floor
- Dose tiers aren't broken out — 'all doses included' means low-dose patients pay the same as high-dose
- Initial consultation cost not shown on the public pricing page
- Limited per-prescriber state licensure detail
Our Verdict
Vytora Health edges out Rx.com with a higher overall score of 8.4/10 and is particularly strong for compounded or brand-name GLP-1 with named pharmacy partners, 50 states. Rx.com remains a solid alternative, especially if you're looking for month-to-month compounded GLP-1s at one flat price per dose, with the pharmacy named.
Choose Rx.com if…
You want month-to-month compounded GLP-1s at one flat price per dose, with the pharmacy named and a starting price around $175/mo.
Choose Vytora Health if…
You want compounded or brand-name GLP-1 with named pharmacy partners, 50 states and a starting price around $150/mo.
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Physician-led, pharmacy-transparent compounded GLP-1 with brand-name options
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Get started →Rx.com vs Vytora Health: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.