Rx.com vs Vytora Health
In our scoring, Vytora Health edges ahead overall (8.4 vs 7.6 out of 10), and Vytora Health costs less for compounded semaglutide (about $127 a year less; one bills every 4 weeks (13 charges a year), so this compares modeled yearly cost).
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Key differences
- Price
- Vytora Health $179/mo vs Rx.com $175/mo for compounded semaglutide (standing prices, no prepay or separate membership listed · about $127 a year less with Vytora Health · one bills every 4 weeks (13 charges a year), so this compares modeled yearly cost)
- Coverage
- Rx.com 49 states; Vytora Health 50 states + DC (only Vytora Health: Alaska and District of Columbia)
- Included
- Rx.com: medication, clinician visits, shipping; Vytora Health: medication, clinician visits, shipping
Rx.com
Best for month-to-month compounded GLP-1s at one flat price per dose, with the pharmacy named
semaglutide
$175
billed every 4 weeks
Our score 7.6/10
Vytora Health
Best for compounded or brand-name GLP-1 with named pharmacy partners, 50 states
semaglutide
$179
Our score 8.4/10
We may earn a commission if you sign up through these links. Partner status can affect which provider we feature; it never changes a score or a price.
Costs & coverage
Published prices with their terms attached. Yearly figures are modeled from the standing price and billing cadence. A check mark marks the better side, on like-for-like rows only.
Rx.com
Vytora Health
Price
Semaglutide / month
$175/mo
billed every 4 weeks
Better on this row: $179/mo
Semaglutide / year (modeled)
$2,275
13 charges
Better on this row: $2,148
Tirzepatide / month
$285/mo
billed every 4 weeks
Better on this row: $249/mo
Tirzepatide / year (modeled)
$3,705
13 charges
Better on this row: $2,988
Brand Zepbound / Mounjaro / month
Not listed
$1,399/mo
Coverage
State availability
49 states
50 states + DC
Brand-name access listed
Not listed
Zepbound / Mounjaro
Included in the price
Medication, clinician visits, shipping
Medication, clinician visits, shipping
Terms & safety
Price shown
Before intake
Before intake
Cancel anytime
Yes
Yes
Minimum commitment
None on the 1-month plan; the 3- and 6-month plans are each one upfront payment ('one payment')
None on monthly plans; 3-month plans are billed every 3 months
Refunds
'Medication cannot be returned once shipped, so medication sales are final.' If a provider decides treatment is not clinically appropriate, 'no prescription will be issued and you will receive a full refund to your original method of payment.' No policy states whether unshipped months of a prepaid plan are refunded on cancellation.
'All sales are final' for prescription products; refund requests 'reviewed on a case-by-case basis'
Early-cancellation fee
None
Not disclosed
FDA warning letters
None on record
None on record
Provider facts checked
September 2026
October 2026
Show where they differ by stateHide state lists
Only Vytora Health (1 state + DC)
- Alaska
- District of Columbia
Every dose and plan: Rx.com · Vytora Health
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Which fits your priorities?
Only the points where these two differ, from the table above and each provider’s record.
Choose Rx.com if…
- Names its dispensing pharmacy (Manifest Pharmacy, Greer, SC) and its provider network (MD Integrations)
- One price covers the provider visit, follow-ups, medication, syringes, alcohol pads and shipping
- No membership, visit, dose-upcharge or shipping fees
What to weigh up
- About $127 a year more than Vytora Health for compounded semaglutide (one bills every 4 weeks (13 charges a year), so this compares modeled yearly cost)
- Not available in Alaska or District of Columbia
Choose Vytora Health if…
- About $127 a year less than Rx.com for compounded semaglutide at standing prices (one bills every 4 weeks (13 charges a year), so this compares modeled yearly cost)
- Lists brand-name Zepbound / Mounjaro, which Rx.com doesn't price
- Serves Alaska and District of Columbia, where Rx.com doesn't
What to weigh up
- Brand-name Mounjaro and Zepbound at $1,399/mo are priced at retail; manufacturer self-pay programs are often cheaper
- Compounded tirzepatide at $249/mo month-to-month is mid-market
Explore the scoring factors
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Rx.com
7.6/10
Vytora Health
8.4/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
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From $99/mo (“starting at” price)
Get started →From $179/mo (starting dose)
Get started →From $149/mo (starting dose)
Get started →Rx.com vs Vytora Health: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.