Amazon One Medical vs Primary Clinic (Direct GLP)
In our scoring, Amazon One Medical edges ahead overall (8.5 vs 6.6 out of 10).
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Key differences
- Price
- Amazon One Medical $199/mo for brand-name Wegovy / Ozempic; Primary Clinic (Direct GLP) $85/mo for compounded semaglutide (different medications, so not compared on price)
- Coverage
- Amazon One Medical 50 states; Primary Clinic (Direct GLP) 9 states + DC (only Amazon One Medical: Alabama, Alaska, Arkansas and 38 more · only Primary Clinic (Direct GLP): District of Columbia)
- Included
- Amazon One Medical: clinician visits, shipping (not included: medication, labs); Primary Clinic (Direct GLP): not stated
Amazon One Medical
Best for brand-name GLP-1s with published per-dose cash prices and Amazon Pharmacy delivery
Brand-name Wegovy / Ozempic
$199
billed every 4 weeks
Our score 8.5/10
Primary Clinic (Direct GLP)
Best for GLP-1 at wholesale cost inside a Direct Primary Care membership
semaglutide
$85
Our score 6.6/10
We may earn a commission if you sign up through these links. Partner status can affect which provider we feature; it never changes a score or a price.
Costs & coverage
Published prices with their terms attached. Yearly figures are modeled from the standing price and billing cadence. A check mark marks the better side, on like-for-like rows only.
Amazon One Medical
Primary Clinic (Direct GLP)
Price
Semaglutide / month
Not listed
$85/mo
Tirzepatide / month
Not listed
$133/mo
Brand Wegovy / Ozempic / month
$199/mo
billed every 4 weeks
Not listed
Brand Zepbound / Mounjaro / month
$299/mo
billed every 4 weeks
Not listed
Brand Wegovy pill / Rybelsus / month
$149/mo
Not listed
Brand Foundayo / month
$149/mo
Not listed
Coverage
State availability
50 states
9 states + DC
Oral option listed
Yes
Not listed
Brand-name access listed
Wegovy / Ozempic, Zepbound / Mounjaro, Wegovy pill / Rybelsus, Foundayo
Not listed
Included in the price
Clinician visits, shipping
Not included: medication, labs
Not disclosed
Terms & safety
Price shown
Before intake
Before intake
Lab work
Required
Not disclosed
Minimum commitment
Not disclosed
Membership
FDA warning letters
None on record
None on record
Provider facts checked
October 2026
August 2026
Show where they differ by stateHide state lists
Only Primary Clinic (Direct GLP) (DC)
- District of Columbia
Only Amazon One Medical (41 states)
- Alabama
- Alaska
- Arkansas
- California
- Colorado
- Connecticut
- Delaware
- Hawaii
- Idaho
- Illinois
- Indiana
- Iowa
- Kentucky
- Louisiana
- Maine
- Maryland
- Massachusetts
- Michigan
- Minnesota
- Mississippi
- Missouri
- Montana
- Nebraska
- Nevada
- New Hampshire
- New Jersey
- New York
- North Carolina
- North Dakota
- Ohio
- Oregon
- Pennsylvania
- Rhode Island
- South Carolina
- South Dakota
- Tennessee
- Texas
- Vermont
- West Virginia
- Wisconsin
- Wyoming
Every dose and plan: Amazon One Medical · Primary Clinic (Direct GLP)
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Which fits your priorities?
Only the points where these two differ, from the table above and each provider’s record.
Choose Amazon One Medical if…
- Lists brand-name Wegovy / Ozempic, brand-name Zepbound / Mounjaro and brand-name Wegovy pill / Rybelsus, which Primary Clinic (Direct GLP) doesn't price
- Serves 41 states that Primary Clinic (Direct GLP) doesn't
- Publishes cash prices for every GLP-1 dose up front, with manufacturer coupons applied automatically if eligible
What to weigh up
- Not available in District of Columbia
- Online On-Demand Care is cash-only for medication; insurance needs scheduled visits near a One Medical office
Choose Primary Clinic (Direct GLP) if…
- Lists compounded semaglutide and compounded tirzepatide, which Amazon One Medical doesn't price
- Serves District of Columbia, where Amazon One Medical doesn't
- Direct Primary Care model integrates GLP-1 with continuous primary care — unlike most direct-to-consumer platforms
What to weigh up
- Not available in 41 states that Amazon One Medical serves
- 10 states only (WA, NM, AZ, UT, FL, DC, KS, OK, VA, GA) — limited vs 50-state platforms
Explore the scoring factors
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Amazon One Medical
8.5/10
Primary Clinic (Direct GLP)
6.6/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Ready to start? Vetted GLP-1 providers
Vetted telehealth providers that prescribe GLP-1 online.
No insurance needed · vetted by our editors
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From $219/mo
Get started →Found
Compounded GLP-1 with medication included from $169/mo cash, plus insurance help for brand GLP-1s
Read full review →From $169/mo
Get started →GobyMeds
No-membership, no-auto-renew compounded GLP-1 orders, from about $99/mo on a 3-month bundle
Read full review →From $169/mo
Get started →Amazon One Medical vs Primary Clinic (Direct GLP): FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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- Primary Clinic (Direct GLP) vs Vytora Health
Or see the full category ranking.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.