Amazon One Medical vs Prime Doctor RX
In our scoring, Amazon One Medical edges ahead overall (8.5 vs 7.0 out of 10).
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Key differences
- Price
- Amazon One Medical $199/mo for brand-name Wegovy / Ozempic; Prime Doctor RX $249/mo for compounded semaglutide (different medications, so not compared on price)
- Coverage
- Amazon One Medical 50 states (Prime Doctor RX doesn't publish a state list)
- Included
- Amazon One Medical: clinician visits, shipping (not included: medication, labs); Prime Doctor RX: medication, clinician visits
Amazon One Medical
Best for brand-name GLP-1s with published per-dose cash prices and Amazon Pharmacy delivery
Brand-name Wegovy / Ozempic
$199
billed every 4 weeks
Our score 8.5/10
Prime Doctor RX
Best for month-to-month compounded GLP-1s with every prepaid tier priced up front, plus TRT
semaglutide
$249
billed every 4 weeks
Our score 7.0/10
We may earn a commission if you sign up through these links. Partner status can affect which provider we feature; it never changes a score or a price.
Costs & coverage
Published prices with their terms attached. Yearly figures are modeled from the standing price and billing cadence. A check mark marks the better side, on like-for-like rows only.
Amazon One Medical
Prime Doctor RX
Price
Semaglutide / month
Not listed
$249/mo
billed every 4 weeks
Tirzepatide / month
Not listed
$339/mo
billed every 4 weeks
Oral semaglutide / month
Not listed
$279/mo
billed every 4 weeks
Brand Wegovy / Ozempic / month
$199/mo
billed every 4 weeks
Not listed
Brand Zepbound / Mounjaro / month
$299/mo
billed every 4 weeks
Not listed
Brand Wegovy pill / Rybelsus / month
$149/mo
Not listed
Brand Foundayo / month
$149/mo
Not listed
Coverage
State availability
50 states
List not published
Oral option listed
Yes
Yes
Brand-name access listed
Wegovy / Ozempic, Zepbound / Mounjaro, Wegovy pill / Rybelsus, Foundayo
Not listed
Included in the price
Clinician visits, shipping
Not included: medication, labs
Medication, clinician visits
Terms & safety
Price shown
Before intake
Before intake
Lab work
Required
Not disclosed
Cancel anytime
Not disclosed
Yes
Minimum commitment
Not disclosed
None on month-to-month plans; optional 12-, 24- and 52-week prepaid plans are one upfront charge
Refunds
Not disclosed
'Refunds may be requested at any time for unused future service periods.' A period is 'generally not refundable once medication for that period has been ordered, prepared, dispensed, or shipped', and professional services already performed 'may be non-refundable'.
FDA warning letters
None on record
None on record
Provider facts checked
October 2026
September 2026
Every dose and plan: Amazon One Medical · Prime Doctor RX
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Which fits your priorities?
Only the points where these two differ, from the table above and each provider’s record.
Choose Amazon One Medical if…
- Lists brand-name Wegovy / Ozempic, brand-name Zepbound / Mounjaro and brand-name Wegovy pill / Rybelsus, which Prime Doctor RX doesn't price
- Publishes its full state list (50 states)
- Publishes cash prices for every GLP-1 dose up front, with manufacturer coupons applied automatically if eligible
What to weigh up
- Price doesn't include medication
- Online On-Demand Care is cash-only for medication; insurance needs scheduled visits near a One Medical office
Choose Prime Doctor RX if…
- Lists compounded semaglutide, compounded tirzepatide and oral compounded semaglutide, which Amazon One Medical doesn't price
- Price includes medication; Amazon One Medical's doesn't
- Every plan is priced on the homepage before you start, with month-to-month and 12-, 24- and 52-week prepaid rates for each drug
What to weigh up
- No published state list; confirm yours at signup
- The '$179/mo' headline is the 52-week prepay average, paid as one $2,327 charge; month-to-month semaglutide is $249
Explore the scoring factors
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Amazon One Medical
8.5/10
Prime Doctor RX
7.0/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
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Ro
FDA-approved brand GLP-1s, including the Wegovy pill and Foundayo, with insurance help
Read full review →From $149/mo (+ required membership)
Get started →ShedRx
Compounded GLP-1 as an injection, drops or lozenges, with lower rates on 6- and 12-month plans
Read full review →From $299/mo (after intro offer)
Get started →bmiMD
One flat compounded GLP-1 price at every dose: semaglutide $159/mo month to month, $119/mo on a 12-month plan
Read full review →From $159/mo
Get started →Amazon One Medical vs Prime Doctor RX: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking, or alternatives to Amazon One Medical and Prime Doctor RX.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.