Primary Clinic (Direct GLP) vs Vytora Health
In our scoring, Vytora Health edges ahead overall (8.4 vs 6.6 out of 10), and Primary Clinic (Direct GLP) costs less for compounded semaglutide (about $1,128 a year less).
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Key differences
- Price
- Primary Clinic (Direct GLP) $85/mo vs Vytora Health $179/mo for compounded semaglutide (standing prices, no prepay or separate membership listed · about $1,128 a year less with Primary Clinic (Direct GLP))
- Coverage
- Primary Clinic (Direct GLP) 9 states + DC; Vytora Health 50 states + DC (only Vytora Health: Alabama, Alaska, Arkansas and 38 more)
- Included
- Primary Clinic (Direct GLP): not stated; Vytora Health: medication, clinician visits, shipping
Primary Clinic (Direct GLP)
Best for GLP-1 at wholesale cost inside a Direct Primary Care membership
semaglutide
$85
Our score 6.6/10
Vytora Health
Best for compounded or brand-name GLP-1 with named pharmacy partners, 50 states
semaglutide
$179
Our score 8.4/10
We may earn a commission if you sign up through these links. Partner status can affect which provider we feature; it never changes a score or a price.
Costs & coverage
Published prices with their terms attached. Yearly figures are modeled from the standing price and billing cadence. A check mark marks the better side, on like-for-like rows only.
Primary Clinic (Direct GLP)
Vytora Health
Price
Semaglutide / month
Better on this row: $85/mo
$179/mo
Semaglutide / year (modeled)
Better on this row: $1,020
$2,148
Tirzepatide / month
Better on this row: $133/mo
$249/mo
Tirzepatide / year (modeled)
Better on this row: $1,596
$2,988
Brand Zepbound / Mounjaro / month
Not listed
$1,399/mo
Coverage
State availability
9 states + DC
50 states + DC
Brand-name access listed
Not listed
Zepbound / Mounjaro
Included in the price
Not disclosed
Medication, clinician visits, shipping
Terms & safety
Price shown
Before intake
Before intake
Cancel anytime
Not disclosed
Yes
Minimum commitment
Membership
None on monthly plans; 3-month plans are billed every 3 months
Refunds
Not disclosed
'All sales are final' for prescription products; refund requests 'reviewed on a case-by-case basis'
FDA warning letters
None on record
None on record
Provider facts checked
August 2026
October 2026
Show where they differ by stateHide state lists
Only Vytora Health (41 states)
- Alabama
- Alaska
- Arkansas
- California
- Colorado
- Connecticut
- Delaware
- Hawaii
- Idaho
- Illinois
- Indiana
- Iowa
- Kentucky
- Louisiana
- Maine
- Maryland
- Massachusetts
- Michigan
- Minnesota
- Mississippi
- Missouri
- Montana
- Nebraska
- Nevada
- New Hampshire
- New Jersey
- New York
- North Carolina
- North Dakota
- Ohio
- Oregon
- Pennsylvania
- Rhode Island
- South Carolina
- South Dakota
- Tennessee
- Texas
- Vermont
- West Virginia
- Wisconsin
- Wyoming
Every dose and plan: Primary Clinic (Direct GLP) · Vytora Health
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Which fits your priorities?
Only the points where these two differ, from the table above and each provider’s record.
Choose Primary Clinic (Direct GLP) if…
- About $1,128 a year less than Vytora Health for compounded semaglutide at standing prices
- Direct Primary Care model integrates GLP-1 with continuous primary care — unlike most direct-to-consumer platforms
- Routine labs and thousands of medications included in membership — no surprise bills
What to weigh up
- Not available in 41 states that Vytora Health serves
- 10 states only (WA, NM, AZ, UT, FL, DC, KS, OK, VA, GA) — limited vs 50-state platforms
Choose Vytora Health if…
- Lists brand-name Zepbound / Mounjaro, which Primary Clinic (Direct GLP) doesn't price
- Serves 41 states that Primary Clinic (Direct GLP) doesn't
- Both compounded and brand-name options on one platform
What to weigh up
- About $1,128 a year more than Primary Clinic (Direct GLP) for compounded semaglutide
- Brand-name Mounjaro and Zepbound at $1,399/mo are priced at retail; manufacturer self-pay programs are often cheaper
Explore the scoring factors
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Primary Clinic (Direct GLP)
6.6/10
Vytora Health
8.4/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
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Found
Compounded GLP-1 with medication included from $169/mo cash, plus insurance help for brand GLP-1s
Read full review →From $169/mo
Get started →GobyMeds
No-membership, no-auto-renew compounded GLP-1 orders, from about $99/mo on a 3-month bundle
Read full review →From $169/mo
Get started →Ivim Health
Compounded GLP-1 with weekly provider check-ins and health coaches, under a required monthly membership
Read full review →From $65/mo + membership
Get started →Primary Clinic (Direct GLP) vs Vytora Health: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.