Amazon One Medical vs PlushCare
In our scoring, Amazon One Medical edges ahead overall (8.5 vs 7.0 out of 10).
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Key differences
- Price
- Amazon One Medical $199/mo for brand-name Wegovy / Ozempic; PlushCare $149/mo for compounded semaglutide (different medications, so not compared on price)
- Coverage
- Both serve the same 50 states
- Included
- Amazon One Medical: clinician visits, shipping (not included: medication, labs); PlushCare: none of the listed items (not included: medication, clinician visits, labs)
Amazon One Medical
Best for brand-name GLP-1s with published per-dose cash prices and Amazon Pharmacy delivery
Brand-name Wegovy / Ozempic
$199
billed every 4 weeks
Our score 8.5/10
PlushCare
Best for virtual primary care that can also prescribe GLP-1s
semaglutide
$149
Our score 7.0/10
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Costs & coverage
Published prices with their terms attached. Yearly figures are modeled from the standing price and billing cadence. A check mark marks the better side, on like-for-like rows only.
Amazon One Medical
PlushCare
Price
Semaglutide / month
Not listed
$149/mo
Tirzepatide / month
Not listed
$399/mo
Brand Wegovy / Ozempic / month
$199/mo
billed every 4 weeks
Not listed
Brand Zepbound / Mounjaro / month
$299/mo
billed every 4 weeks
Not listed
Brand Wegovy pill / Rybelsus / month
$149/mo
Not listed
Brand Foundayo / month
$149/mo
Not listed
Coverage
State availability
50 states
50 states
Oral option listed
Yes
Not listed
Brand-name access listed
Wegovy / Ozempic, Zepbound / Mounjaro, Wegovy pill / Rybelsus, Foundayo
Not listed
Included in the price
Clinician visits, shipping
Not included: medication, labs
None of the listed items
Not included: medication, clinician visits, labs
Terms & safety
Price shown
Before intake
Before intake
Lab work
Required
Required
Video visit
Not disclosed
Required
Minimum commitment
Not disclosed
Membership
FDA warning letters
None on record
None on record
Provider facts checked
October 2026
August 2026
Every dose and plan: Amazon One Medical · PlushCare
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Which fits your priorities?
Only the points where these two differ, from the table above and each provider’s record.
Choose Amazon One Medical if…
- Lists brand-name Wegovy / Ozempic, brand-name Zepbound / Mounjaro and brand-name Wegovy pill / Rybelsus, which PlushCare doesn't price
- Price includes clinician visits; PlushCare's doesn't
- Publishes cash prices for every GLP-1 dose up front, with manufacturer coupons applied automatically if eligible
What to weigh up
- Online On-Demand Care is cash-only for medication; insurance needs scheduled visits near a One Medical office
- You must provide recent lab results (kidney function and glucose or A1c), bought separately if you have none
Choose PlushCare if…
- Lists compounded semaglutide and compounded tirzepatide, which Amazon One Medical doesn't price
- Appointments with US board-certified physicians, not nurse practitioners only
- Virtual primary care — the same doctor can manage GLP-1s alongside other health needs
What to weigh up
- Price doesn't include clinician visits
- Facing a California class action alleging deceptive subscription enrollment and unauthorized charges after cancellation
Explore the scoring factors
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Amazon One Medical
8.5/10
PlushCare
7.0/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Ready to start? Vetted GLP-1 providers
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Ivim Health
Compounded GLP-1 with weekly provider check-ins and health coaches, under a required monthly membership
Read full review →From $65/mo + membership
Get started →From $247/mo
Get started →From $139/mo
Get started →Amazon One Medical vs PlushCare: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.