Amazon One Medical vs Medsol RX
In our scoring, Amazon One Medical edges ahead overall (8.5 vs 7.4 out of 10), and Amazon One Medical costs less for brand-name Wegovy / Ozempic (about $12,161 a year less; one bills every 4 weeks (13 charges a year), so this compares modeled yearly cost).
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Key differences
- Price
- Amazon One Medical $199/mo vs Medsol RX $1,229/mo for brand-name Wegovy / Ozempic (standing prices, no prepay or separate membership listed · about $12,161 a year less with Amazon One Medical · one bills every 4 weeks (13 charges a year), so this compares modeled yearly cost)
- Coverage
- Both serve the same 50 states
- Included
- Amazon One Medical: clinician visits, shipping (not included: medication, labs); Medsol RX: medication, clinician visits, shipping, coaching
Amazon One Medical
Best for brand-name GLP-1s with published per-dose cash prices and Amazon Pharmacy delivery
Brand-name Wegovy / Ozempic
$199
billed every 4 weeks
Our score 8.5/10
Medsol RX
Best for flexible, HSA/FSA-eligible compounded GLP-1 plans with a care coach
semaglutide
$149
microdose plan
Our score 7.4/10
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Costs & coverage
Published prices with their terms attached. Yearly figures are modeled from the standing price and billing cadence. A check mark marks the better side, on like-for-like rows only.
Amazon One Medical
Medsol RX
Price
Brand Wegovy / Ozempic / month
Better on this row: $199/mo
billed every 4 weeks
$1,229/mo
Brand Wegovy / Ozempic / year (modeled)
Better on this row: $2,587
13 charges
$14,748
Brand Zepbound / Mounjaro / month
Better on this row: $299/mo
billed every 4 weeks
$1,399/mo
Brand Zepbound / Mounjaro / year (modeled)
Better on this row: $3,887
13 charges
$16,788
Semaglutide / month
Not listed
$149/mo
microdose plan
Tirzepatide / month
Not listed
$259/mo
$239 first month
Tirzepatide (pill or injection) / month
Not listed
$149/mo
microdose plan
Oral semaglutide / month
Not listed
$179/mo
Brand Wegovy pill / Rybelsus / month
$149/mo
Not listed
Brand Foundayo / month
$149/mo
Not listed
Coverage
State availability
50 states
50 states
Oral option listed
Yes
Yes
Brand-name access listed
Wegovy / Ozempic, Zepbound / Mounjaro, Wegovy pill / Rybelsus, Foundayo
Wegovy / Ozempic, Zepbound / Mounjaro
Included in the price
Clinician visits, shipping
Not included: medication, labs
Medication, clinician visits, shipping, coaching
FSA/HSA accepted
Not listed
Yes
Terms & safety
Price shown
Before intake
Before intake
Lab work
Required
Not disclosed
Cancel anytime
Not disclosed
Yes
Minimum commitment
Not disclosed
None
Refunds
Not disclosed
Full refund only if canceled within 72 hours before any services or if medically disqualified; monthly charges are non-refundable
FDA warning letters
None on record
None on record
Provider facts checked
October 2026
October 2026
Every dose and plan: Amazon One Medical · Medsol RX
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Which fits your priorities?
Only the points where these two differ, from the table above and each provider’s record.
Choose Amazon One Medical if…
- About $12,161 a year less than Medsol RX for brand-name Wegovy / Ozempic at standing prices (one bills every 4 weeks (13 charges a year), so this compares modeled yearly cost)
- Lists brand-name Wegovy pill / Rybelsus and brand-name Foundayo, which Medsol RX doesn't price
- Publishes cash prices for every GLP-1 dose up front, with manufacturer coupons applied automatically if eligible
What to weigh up
- Price doesn't include medication
- Online On-Demand Care is cash-only for medication; insurance needs scheduled visits near a One Medical office
Choose Medsol RX if…
- Lists compounded semaglutide, compounded tirzepatide and compounded tirzepatide (pill or injection), which Amazon One Medical doesn't price
- Price includes medication; Amazon One Medical's doesn't
- Accepts FSA/HSA cards
What to weigh up
- About $12,161 a year more than Amazon One Medical for brand-name Wegovy / Ozempic (one bills every 4 weeks (13 charges a year), so this compares modeled yearly cost)
- Monthly charges are non-refundable once billed; cancel at least 72 hours before your next billing date
Explore the scoring factors
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Amazon One Medical
8.5/10
Medsol RX
7.4/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
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Collective
The lowest flat medication price if you can absorb an annual membership fee
Read full review →From $59/mo (+ required membership)
Get started →CoreAge Rx
Lowest-price compounded semaglutide and tirzepatide with one flat price at every dose
Read full review →From $79/mo (“starting at” price)
Get started →From $79/mo (sale price)
Get started →Amazon One Medical vs Medsol RX: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
Related comparisons
Continue exploring Amazon One Medical and Medsol RX head-to-heads in the same category.
- Amazon One Medical vs Vytora Health
- Amazon One Medical vs CoreAge Rx
- Amazon One Medical vs Collective
- Medsol RX vs Vytora Health
Or see the full category ranking, or alternatives to Amazon One Medical and Medsol RX.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.