Amazon One Medical vs Luma Health Co
In our scoring, Amazon One Medical edges ahead overall (8.5 vs 7.1 out of 10).
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Key differences
- Price
- Amazon One Medical $199/mo for brand-name Wegovy / Ozempic; Luma Health Co $115/mo for compounded semaglutide (different medications, so not compared on price)
- Coverage
- Amazon One Medical 50 states; Luma Health Co 29 states + DC (only Amazon One Medical: Alabama, Alaska, Arkansas and 18 more · only Luma Health Co: District of Columbia)
- Included
- Amazon One Medical: clinician visits, shipping (not included: medication, labs); Luma Health Co: medication
Amazon One Medical
Best for brand-name GLP-1s with published per-dose cash prices and Amazon Pharmacy delivery
Brand-name Wegovy / Ozempic
$199
billed every 4 weeks
Our score 8.5/10
Luma Health Co
Best for no-subscription compounded GLP-1s, discounted for first responders & teachers
semaglutide
$115
Our score 7.1/10
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Costs & coverage
Published prices with their terms attached. Yearly figures are modeled from the standing price and billing cadence. A check mark marks the better side, on like-for-like rows only.
Amazon One Medical
Luma Health Co
Price
Semaglutide / month
Not listed
$115/mo
Tirzepatide / month
Not listed
$180/mo
Brand Wegovy / Ozempic / month
$199/mo
billed every 4 weeks
Not listed
Brand Zepbound / Mounjaro / month
$299/mo
billed every 4 weeks
Not listed
Brand Wegovy pill / Rybelsus / month
$149/mo
Not listed
Brand Foundayo / month
$149/mo
Not listed
Coverage
State availability
50 states
29 states + DC
Oral option listed
Yes
Not listed
Brand-name access listed
Wegovy / Ozempic, Zepbound / Mounjaro, Wegovy pill / Rybelsus, Foundayo
Not listed
Included in the price
Clinician visits, shipping
Not included: medication, labs
Medication
Terms & safety
Price shown
Before intake
Before intake
Lab work
Required
Required
Video visit
Not disclosed
Required
FDA warning letters
None on record
None on record
Provider facts checked
October 2026
August 2026
Show where they differ by stateHide state lists
Only Luma Health Co (DC)
- District of Columbia
Only Amazon One Medical (21 states)
- Alabama
- Alaska
- Arkansas
- California
- Georgia
- Indiana
- Kansas
- Kentucky
- Michigan
- Mississippi
- Missouri
- New Jersey
- North Carolina
- Ohio
- Oklahoma
- Pennsylvania
- South Carolina
- Tennessee
- Virginia
- West Virginia
- Wisconsin
Every dose and plan: Amazon One Medical · Luma Health Co
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Which fits your priorities?
Only the points where these two differ, from the table above and each provider’s record.
Choose Amazon One Medical if…
- Lists brand-name Wegovy / Ozempic, brand-name Zepbound / Mounjaro and brand-name Wegovy pill / Rybelsus, which Luma Health Co doesn't price
- Serves 21 states that Luma Health Co doesn't
- Publishes cash prices for every GLP-1 dose up front, with manufacturer coupons applied automatically if eligible
What to weigh up
- Not available in District of Columbia
- Price doesn't include medication
Choose Luma Health Co if…
- Lists compounded semaglutide and compounded tirzepatide, which Amazon One Medical doesn't price
- Serves District of Columbia, where Amazon One Medical doesn't
- Price includes medication; Amazon One Medical's doesn't
What to weigh up
- Not available in 21 states that Amazon One Medical serves
- Offers compounded retatrutide (labeled "RTT/GLP-3"), an investigational triple agonist not FDA-approved — a higher-risk, less-studied option
Explore the scoring factors
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Amazon One Medical
8.5/10
Luma Health Co
7.1/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
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Amazon One Medical vs Luma Health Co: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.