Is 1st Optimal or MD Trim Clinic cheaper?

1st Optimal does not publicly list a standard ongoing cash price, while MD Trim Clinic does not publicly list one. See the side-by-side pricing above for the full breakdown.

Which is better overall, 1st Optimal or MD Trim Clinic?

1st Optimal scores higher overall at 6.7/10 versus 5.8/10, and is particularly strong for Patients wanting GLP-1 therapy within a lab-driven functional-medicine program. That said, MD Trim Clinic is a better fit if you want DO+NP-led compounded sema/tirz clinic; tiered dosing, AZ+CA telehealth + in-office, B12 anti-nausea.

Does 1st Optimal or MD Trim Clinic cover more states?

MD Trim Clinic lists availability in 2 states, while 1st Optimal's state list is not publicly listed.

Is 1st Optimal or MD Trim Clinic an affiliate partner of Weight Loss Rankings?

Neither 1st Optimal nor MD Trim Clinic is currently an affiliate partner, so we earn no commission from either. We rank all providers editorially using the same six-dimension framework and disclose any commercial relationships.

Always verify pricing and state availability on the provider's website before signing up.How our reviews work →

1st Optimal vs MD Trim Clinic

Name: 1st Optimal
Brand: 1st Optimal

An in-depth comparison of two leading GLP-1 Providers

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1st Optimal

6.7

★★★☆☆3.4

Best for: Patients wanting GLP-1 therapy within a lab-driven functional-medicine program

Visit 1st Optimal →

MD Trim Clinic

5.8

★★★☆☆2.9

Best for: DO+NP-led compounded sema/tirz clinic; tiered dosing, AZ+CA telehealth + in-office, B12 anti-nausea

Visit MD Trim Clinic →

1st Optimal and MD Trim Clinic are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, 1st Optimal edges ahead overall (6.7 vs 5.8 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.

What’s included

1st Optimal

Inclusions not disclosed.

MD Trim Clinic

What the monthly price covers

Medication

Included

Provider visits

Included

Shipping

Included

Lab work

Billed separately

Coaching

Billed separately

Score breakdown

Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.

1st Optimal

6.7/10

Overall

MD Trim Clinic

5.8/10

Value25%

6.5

5.0

Effectiveness25%

7.0

6.5

User Experience15%

6.5

5.5

Trust & Safety15%

6.5

7.0

Accessibility10%

6.5

3.5

Support10%

7.0

Features & Coverage

Feature	1st Optimal	MD Trim Clinic
Starting Price	—	—
Features	8 features	8 features
States Available	Not disclosed	2
Compounded	—	—
Brand Name	—	—
FSA/HSA Accepted	—	—
FDA Warnings	None	None

About 1st Optimal

1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.

Read our full 1st Optimal review →

About MD Trim Clinic

MD Trim Clinic is a small physician-led practice in Phoenix, AZ and Novato, CA offering compounded semaglutide and tirzepatide via telehealth and in-person visits. Medications are dispensed from LegitScript-certified pharmacies with B12 added to reduce nausea, and programs are tiered by weekly dose (Level 1 / Level 2). Led by Dr. Brandon Shaw, D.O. and nurse practitioner Andrea Farris, N.P., the clinic includes free initial screening, physician-guided dosing titration, and ongoing team support.

Read our full MD Trim Clinic review →

Pros & Cons

1st Optimal

What we like

Offers both semaglutide and tirzepatide with injectable and oral formats
Functional-medicine approach with at-home labs and blood-work interpretation
Unlimited coaching and ongoing support included
No long-term contracts
Board-certified doctors and nurse practitioners referenced

Watch-outs

No public monthly pricing disclosed
No published state availability list
Compounded vs branded sourcing not clarified on site
Pricing only revealed after quiz or consultation

MD Trim Clinic

What we like

Physician DO + NP team (Dr. Brandon Shaw, D.O. and Andrea Farris, N.P.) provides strong clinical oversight
Compounded meds from LegitScript-certified pharmacies — higher supply-chain trust than many small practices
Tiered dosing structure (Level 1 / Level 2) with B12 added to reduce nausea side effects
Both telehealth and in-person options available (AZ Phoenix and CA Novato offices)
Partnered mobile IV services available for enhanced nausea management and hydration support

Watch-outs

Pricing not disclosed publicly — must contact clinic for quotes, limiting upfront comparison shopping
Only AZ and CA confirmed — very limited geographic reach, excludes nearly all of the US
No LegitScript certification for the clinic itself (only pharmacy partners are LegitScript-certified)
Small practice with limited online presence and no published patient reviews or outcomes data
No labs, coaching, or monitoring protocols disclosed on the site

Our Verdict

Winner: 1st Optimal

1st Optimal edges out MD Trim Clinic with a higher overall score of 6.7/10 and is particularly strong for Patients wanting GLP-1 therapy within a lab-driven functional-medicine program. MD Trim Clinic remains a solid alternative, especially if you're looking for DO+NP-led compounded sema/tirz clinic; tiered dosing, AZ+CA telehealth + in-office, B12 anti-nausea.

Choose 1st Optimal if…

You want Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.

Visit 1st Optimal →

Choose MD Trim Clinic if…

You want DO+NP-led compounded sema/tirz clinic; tiered dosing, AZ+CA telehealth + in-office, B12 anti-nausea.

Visit MD Trim Clinic →

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1st Optimal vs MD Trim Clinic: FAQ

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Key terms, explained

New to GLP-1s? Tap any term for a quick, plain-English definition.

Semaglutide · Drugs and brands
Tirzepatide · Drugs and brands
Compounded GLP-1 · Pharmacy and drug forms
503A pharmacy · Pharmacy and drug forms
PCAB accreditation · Pharmacy and drug forms
Prior authorization (PA) · Insurance and regulatory
Off-label use · Insurance and regulatory
FDA Drug Shortage List · Insurance and regulatory

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