1st Optimal vs MD Trim Clinic
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →
MD Trim Clinic
Best for: DO+NP-led compounded GLP-1 clinic; AZ+CA telehealth or in-office
Visit MD Trim Clinic →1st Optimal and MD Trim Clinic are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, 1st Optimal starts at $99/mo, and 1st Optimal edges ahead overall (6.7 vs 5.8 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Care membership only — the GLP-1 medication is billed separately and is not priced.
MD Trim Clinic
Pricing not publicly listed.
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What’s included
1st Optimal
What the monthly price covers
Medication
Not disclosed
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Included
MD Trim Clinic
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Billed separately
Coaching
Billed separately
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
MD Trim Clinic
5.8/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | MD Trim Clinic |
|---|---|---|
| Starting Price | $99/mo | — |
| Features | 8 features | 8 features |
| States Available | Not disclosed | 2 |
| Compounded | — | — |
| Brand Name | ✓ Yes | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About MD Trim Clinic
MD Trim Clinic is a small physician-led practice in Phoenix, AZ and Novato, CA offering compounded semaglutide and tirzepatide via telehealth and in-person visits. Medications are dispensed from LegitScript-certified pharmacies with B12 added to reduce nausea, and programs are tiered by weekly dose (Level 1 / Level 2). Led by Dr. Brandon Shaw, D.O. and nurse practitioner Andrea Farris, N.P., the clinic includes free initial screening, physician-guided dosing titration, and ongoing team support.
Read our full MD Trim Clinic review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
MD Trim Clinic
What we like
- Physician DO + NP team (Dr. Brandon Shaw, D.O. and Andrea Farris, N.P.) provides strong clinical oversight
- Compounded meds from LegitScript-certified pharmacies — higher supply-chain trust than many small practices
- Tiered dosing structure (Level 1 / Level 2) with B12 added to reduce nausea side effects
- Both telehealth and in-person options available (AZ Phoenix and CA Novato offices)
- Partnered mobile IV services available for enhanced nausea management and hydration support
Watch-outs
- Pricing not disclosed publicly — must contact clinic for quotes, limiting upfront comparison shopping
- Only AZ and CA confirmed — very limited geographic reach, excludes nearly all of the US
- No LegitScript certification for the clinic itself (only pharmacy partners are LegitScript-certified)
- Small practice with limited online presence and no published patient reviews or outcomes data
- No labs, coaching, or monitoring protocols disclosed on the site
Our Verdict
1st Optimal edges out MD Trim Clinic with a higher overall score of 6.7/10 and is particularly strong for GLP-1 therapy within a lab-driven functional-medicine program. MD Trim Clinic remains a solid alternative, especially if you're looking for DO+NP-led compounded GLP-1 clinic; AZ+CA telehealth or in-office.
Choose 1st Optimal if…
You want GLP-1 therapy within a lab-driven functional-medicine program and a starting price around $99/mo.
Choose MD Trim Clinic if…
You want DO+NP-led compounded GLP-1 clinic; AZ+CA telehealth or in-office.
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Budget-conscious shoppers
From $99/mo
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From $149/mo
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Mainstream telehealth GLP-1 access
From $99/mo
Get started →1st Optimal vs MD Trim Clinic: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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