10rx vs He & She MD
An in-depth comparison of two leading GLP-1 Providers
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He & She MD
Best for: Cheapest per-month GLP-1 if you can prepay a full year
Visit He & She MD →10rx and He & She MD are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, 10rx starts lower at $96.67/mo versus $99/mo, and He & She MD edges ahead overall (7.5 vs 7.1 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
10rx
He & She MD
Annual plan: billed $1,188 upfront. Advertised as a limited-time rate (banner: 'Injectable Semaglutide $199/month from just $99/month').
Billed $834 every 6 months, saving $360 vs monthly. Homepage GLP-1 Platinum starter rate: $139/mo for the first 6 months, then renews at $1,194 per 6 months, equivalent to $199/mo.
Billed $447 every 3 months, saving $270 vs monthly.
Billed monthly; the standing rate every term plan discounts from.
GLP-1 Platinum oral: $199/mo for the first 6 months, then renews at $1,434 per 6 months, equivalent to $239/mo. Oral is not on the /weight-loss/plans term ladder; figures from the homepage program cards and footnote 3.
Annual plan: billed $1,908 upfront.
Billed $1,194 every 6 months, saving $540 vs monthly. Homepage GLP-1 Platinum starter rate: $199/mo to start, then renews at $1,734 per 6 months, equivalent to $289/mo.
Billed $627 every 3 months, saving $270 vs monthly.
Billed monthly; the standing rate.
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What’s included
10rx
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
He & She MD
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Included
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
10rx
7.1/10
He & She MD
7.5/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 10rx | He & She MD |
|---|---|---|
| Starting Price | ✓$96.67/mo | $99/mo |
| Features | 8 features | 8 features |
| States Available | Not disclosed | 50 |
| Compounded | — | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 10rx
10rx is a nationwide GLP-1 telehealth program offering compounded weight-loss medication at low flat monthly rates: semaglutide at $99.67/month and tirzepatide at $149.67/month, with NAD+ and sermorelin also offered for energy and recovery. You take a free online health quiz, a board-certified telehealth doctor reviews your history and prescribes if appropriate, and licensed pharmacy partners ship discreetly. 10rx says it ships to all 50 states, but it doesn't publish its operating company, name its pharmacies, or post a terms page.
Read our full 10rx review →About He & She MD
He & She MD is a nationwide cash-pay telehealth clinic prescribing compounded semaglutide and tirzepatide, injectable or oral, plus brand-name access to Ozempic, Wegovy and Zepbound. Injectable semaglutide is $199/month billed monthly, falling to $139 on a six-month plan and $99 on the annual plan, prepaid for the year; tirzepatide runs $299/month down to $159 annually. Plans bundle medication, injection supplies, free shipping, unlimited provider messaging and GLP-1 coaching, and you are charged only if a clinician prescribes. Ships everywhere except Louisiana. LegitScript-certified.
Read our full He & She MD review →Pros & Cons
10rx
What we like
- Very low pricing — compounded semaglutide $99.67/month and tirzepatide $149.67/month
- Free online health quiz with board-certified telehealth doctors reviewing eligibility
- Offers NAD+ and sermorelin alongside GLP-1, for energy and muscle recovery
- Says it ships to all 50 states with discreet delivery from licensed pharmacy partners
Watch-outs
- Doesn't publish its legal operating entity, so accountability is hard to verify
- Pharmacy partners are described as licensed but none are named
- No terms-of-service page is posted, and FAQ answers load only via script
- Compounded semaglutide and tirzepatide only — no brand-name or oral options
- No LegitScript or third-party accreditation is shown on the site
He & She MD
What we like
- Injectable semaglutide from $99/month on the annual plan, or $139/month on a six-month plan
- Compounded semaglutide and tirzepatide, injectable or oral, plus brand access to Ozempic, Wegovy, Zepbound
- Only charged if medication is prescribed, and no membership fees
- Every plan includes medication, injection supplies, free shipping and unlimited provider messaging
- GLP-1 coaching, nutrition guidance, and in-app progress tracking
- LegitScript-certified, and it names both compounding pharmacies it uses
- Ships to 49 states (all except Louisiana)
Watch-outs
- Compounded GLP-1s are not FDA-approved finished products (per the site FDA disclaimer)
- Does not ship to Louisiana or to PO boxes
- The $99 and $159 headline rates require a full year prepaid in a single charge
- Month-to-month costs $199 for semaglutide and $299 for tirzepatide, roughly double the annual rate
- Six-month starter rates step up on renewal: semaglutide $139 to $199, tirzepatide $199 to $289
- Cash-pay model, insurance billing not indicated
Our Verdict
He & She MD edges out 10rx with a higher overall score of 7.5/10 and is particularly strong for Cheapest per-month GLP-1 if you can prepay a full year. 10rx remains a solid alternative, especially if you're looking for low-cost compounded GLP-1 with NAD+ and sermorelin add-ons.
Choose 10rx if…
You want low-cost compounded GLP-1 with NAD+ and sermorelin add-ons and a starting price around $96.67/mo.
Choose He & She MD if…
You want Cheapest per-month GLP-1 if you can prepay a full year and a starting price around $99/mo.
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Synergy Rx
Broadest drug catalog in the Lion MD white-label cluster
From $199/mo
Get started →RxSpan MD
Physician-led, pharmacy-transparent compounded GLP-1 with brand-name options
From $179/mo
Get started →Strut Health
Oral-lozenge compounded GLP-1 access
From $99/mo
Get started →10rx vs He & She MD: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.