SUMMIT

Definition

The phase 3 trial of tirzepatide in adults with heart failure with preserved ejection fraction (HFpEF) and obesity. Packer and colleagues (NEJM 2025) reported substantial improvement in HFpEF-specific outcomes — the tirzepatide complement to STEP-HFpEF.

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Definition curated by Weight Loss Rankings — sourced from FDA labels and peer-reviewed PubMed literature, never AI-generated summaries.

Related terms in trial

• SURMOUNT-5
• SURMOUNT-2
• SURMOUNT-3
• SURPASS-2
• SUSTAIN-6
• REWIND
• PIONEER 6
• STEP-HFpEF
• EXSCEL
• ELIXA
• AMPLITUDE-O
• HARMONY OUTCOMES
• SCALE Diabetes
• STEP 2
• SCALE Maintenance

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