ELIXA

Definition

The cardiovascular safety trial of lixisenatide (Adlyxin) in adults with type 2 diabetes following an acute coronary syndrome. Pfeffer and colleagues (NEJM 2015) demonstrated cardiovascular safety (noninferiority for MACE) but no superiority — the first GLP-1 cardiovascular outcomes trial completed under the post-2008 FDA CV-safety guidance.

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Definition curated by Weight Loss Rankings — sourced from FDA labels and peer-reviewed PubMed literature, never AI-generated summaries.

Related terms in trial

• SURMOUNT-5
• SURMOUNT-2
• SURMOUNT-3
• SURPASS-2
• SUSTAIN-6
• REWIND
• PIONEER 6
• STEP-HFpEF
• EXSCEL
• AMPLITUDE-O
• HARMONY OUTCOMES
• SCALE Diabetes
• STEP 2
• SUMMIT
• SCALE Maintenance

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