STEP-HFpEF

Definition

The phase 3 trial of semaglutide 2.4 mg in adults with heart failure with preserved ejection fraction (HFpEF) and obesity. Kosiborod and colleagues (NEJM 2023) reported substantial improvement in Kansas City Cardiomyopathy Questionnaire clinical summary score and 6-minute walk distance — the first GLP-1 trial demonstrating heart-failure-specific symptomatic benefit.

STEP-HFpEF trial deep-dive →

Definition curated by Weight Loss Rankings — sourced from FDA labels and peer-reviewed PubMed literature, never AI-generated summaries.

Related terms in trial

• SURMOUNT-5
• SURMOUNT-2
• SURMOUNT-3
• SURPASS-2
• SUSTAIN-6
• REWIND
• PIONEER 6
• EXSCEL
• ELIXA
• AMPLITUDE-O
• HARMONY OUTCOMES
• SCALE Diabetes
• STEP 2
• SUMMIT
• SCALE Maintenance

Looking for more depth?

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