SURMOUNT-3

Definition

The phase 3 trial of tirzepatide after a 12-week intensive lifestyle-intervention lead-in. Wadden and colleagues (Nature Medicine 2023) showed an additional -18.4% body weight reduction on tirzepatide compared to -2.5% on placebo over the 72-week treatment period following the lifestyle run-in — demonstrating tirzepatide and lifestyle therapy are additive.

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Definition curated by Weight Loss Rankings — sourced from FDA labels and peer-reviewed PubMed literature, never AI-generated summaries.

Related terms in trial

• SURMOUNT-5
• SURMOUNT-2
• SURPASS-2
• SUSTAIN-6
• REWIND
• PIONEER 6
• STEP-HFpEF
• EXSCEL
• ELIXA
• AMPLITUDE-O
• HARMONY OUTCOMES
• SCALE Diabetes
• STEP 2
• SUMMIT
• SCALE Maintenance

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