KCCQ-CSS (Kansas City Cardiomyopathy Questionnaire — Clinical Summary Score)
The pivotal Phase 3 trials and post-approval cardiovascular, kidney, and sleep-apnea outcome studies.
Definition
A validated patient-reported outcome measure for heart failure symptoms and physical limitations. Scored 0-100, higher is better. A 5-point improvement is considered clinically meaningful. STEP-HFpEF reported a 7.8-point KCCQ-CSS improvement on semaglutide vs 2.6 on placebo — the primary endpoint that drove the 2024 EMA / FDA filings for semaglutide in HFpEF + obesity.
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Definition curated by Weight Loss Rankings — sourced from FDA labels and peer-reviewed PubMed literature, never AI-generated summaries.
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