EXSCEL

Definition

The cardiovascular outcomes trial of once-weekly exenatide (Bydureon) in 14,752 adults with type 2 diabetes. Holman and colleagues (NEJM 2017) reported a neutral primary outcome — exenatide did not significantly reduce MACE, distinguishing it from the semaglutide / liraglutide / dulaglutide CV-benefit trials.

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Definition curated by Weight Loss Rankings — sourced from FDA labels and peer-reviewed PubMed literature, never AI-generated summaries.

Related terms in trial

• SURMOUNT-5
• SURMOUNT-2
• SURMOUNT-3
• SURPASS-2
• SUSTAIN-6
• REWIND
• PIONEER 6
• STEP-HFpEF
• ELIXA
• AMPLITUDE-O
• HARMONY OUTCOMES
• SCALE Diabetes
• STEP 2
• SUMMIT
• SCALE Maintenance

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