SUSTAIN-6

Definition

The cardiovascular outcomes trial of semaglutide in adults with type 2 diabetes at high cardiovascular risk. Marso and colleagues (NEJM 2016) reported a 26% relative reduction in the three-point MACE composite (cardiovascular death, nonfatal MI, nonfatal stroke). Established the cardiovascular safety + benefit signal that later trials confirmed.

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Definition curated by Weight Loss Rankings — sourced from FDA labels and peer-reviewed PubMed literature, never AI-generated summaries.

Related terms in trial

• SURMOUNT-5
• SURMOUNT-2
• SURMOUNT-3
• SURPASS-2
• REWIND
• PIONEER 6
• STEP-HFpEF
• EXSCEL
• ELIXA
• AMPLITUDE-O
• HARMONY OUTCOMES
• SCALE Diabetes
• STEP 2
• SUMMIT
• SCALE Maintenance

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