Yes Clinic vs NewSelf
An in-depth comparison of two leading GLP-1 Providers
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Yes Clinic
Best for: flat per-dose pricing, and seeing every price without a quiz or an account
Visit Yes Clinic →
NewSelf
Best for: lowest-cost compounded GLP-1 with pharmacy quality transparency
Visit NewSelf →Yes Clinic and NewSelf are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, NewSelf starts lower at $100/mo versus $129/mo, and NewSelf edges ahead overall (8.3 vs 7.8 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
Yes Clinic
$387 for 3 months = $129/mo. 6 months is $699 = $116.50/mo and is labelled "price locked". No single-month plan renders. Flat at every dose.
$447 for 3 months and $894 for 6 months both work out at $149/mo, "price locked". No single-month plan renders. Flat at every dose.
NewSelf
All dosages same price
All dosages same price
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What’s included
Yes Clinic
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
NewSelf
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Yes Clinic
7.8/10
NewSelf
8.3/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | Yes Clinic | NewSelf |
|---|---|---|
| Starting Price | $129/mo | ✓$100/mo |
| Features | 6 features | 6 features |
| States Available | Not disclosed | 49 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | ✓None | 1 warning |
About Yes Clinic
Yes Clinic sells compounded semaglutide and tirzepatide at one flat price that does not rise as your dose is titrated up — $129/mo for semaglutide and $149/mo for tirzepatide, with the consultation, shipping and membership all at $0. Every price is published on the product page without a quiz or an account. The trade-off is that the smallest plan is a three-month prepay charged upfront.
Read our full Yes Clinic review →About NewSelf
NewSelf offers compounded semaglutide+ (with B12/Glycine, from $99.97/mo) and compounded tirzepatide+ (with B6/Glycine, from $144.49/mo). LegitScript certified. Available in 48 states + Puerto Rico. Uses 503A licensed pharmacies with third-party testing.
Read our full NewSelf review →Pros & Cons
Yes Clinic
What we like
- Flat price at every dose — $129/mo semaglutide, $149/mo tirzepatide, and it does not climb as you titrate
- At $129/mo semaglutide sits only $20 below tirzepatide, so stepping up costs little
- "Every price is on this page. No quiz and no account needed to see it" — no email wall to see cost
- Consultation ($30), shipping and membership are all listed at $0: "the price on the tile is the whole price"
- Full refund if you cancel before the pharmacy dispenses; cancel yourself from your account
- Bilingual site with a working EN/ES toggle
Watch-outs
- Smallest plan is a 3-month prepay — $387 or $447 charged upfront, not a monthly bill
- Their live Terms of Use still contains an unfilled template placeholder: governed by the laws of the State of {GOVERNING_LAW_STATE}
- No pharmacy partner is named despite a "LegitScript Certified" banner in the footer
- No state list published: "Services are not available in all states"
- Product pages served different prices in source HTML than they render, so quote the figure you see on screen
- Support is email-only; no phone number published
NewSelf
What we like
- Semaglutide+ from $99.97/mo — among the lowest prices in the dataset
- All dosages at the same price — no price escalation as dose increases
- LegitScript certified with 503A licensed pharmacies
- Third-party potency, sterility, and endotoxicity testing
- 48 states + Puerto Rico coverage
- B12/B6 + Glycine enhanced formulations
- No membership fees
Watch-outs
- Not available in Mississippi and Louisiana
- Compounded only — no brand-name options
- Site also promotes AI health optimization and longevity (broader platform)
Our Verdict
NewSelf edges out Yes Clinic with a higher overall score of 8.3/10 and is particularly strong for lowest-cost compounded GLP-1 with pharmacy quality transparency. Yes Clinic remains a solid alternative, especially if you're looking for flat per-dose pricing, and seeing every price without a quiz or an account.
Choose Yes Clinic if…
You want flat per-dose pricing, and seeing every price without a quiz or an account and a starting price around $129/mo.
Choose NewSelf if…
You want lowest-cost compounded GLP-1 with pharmacy quality transparency and a starting price around $100/mo.
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Strut Health
Oral-lozenge compounded GLP-1 access
From $99/mo
Get started →Yucca Health
Mainstream telehealth GLP-1 access
From $146/mo
Get started →TrimRx
Best overall value
From $149/mo
Get started →Yes Clinic vs NewSelf: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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