TrimRx vs NewSelf
An in-depth comparison of two leading GLP-1 Providers
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NewSelf
Best for: lowest-cost compounded GLP-1 with pharmacy quality transparency
Visit NewSelf →TrimRx and NewSelf are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, NewSelf starts lower at $100/mo versus $179/mo, and TrimRx is the option we'd start with for most patients. Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
TrimRx
Homepage tier 'GLP-1 Starting at $179'; hero checkout mockup shows $299.00 list struck to $179.00/1st mo; email-capture popup offers '$120 OFF for your first order — GET YOUR FIRST MONTH AS LOW AS $135'. Multi-month bundle prices ($209/$191/$174 recorded 2026-07-10) are NO LONGER published — old public checkout 404s, plans now quiz-gated.
Homepage tier 'GLP-1 + GIP Starting at $259' (hero mockup: 'GLP-1 + GIP Medication Contains Tirzepatide') — DOWN from the $279 checkout limited offer we recorded 2026-07-10; bundle prices ($316/$299/$283) no longer published (quiz-gated).
'Mounjaro® Starting at $1249' homepage tile; same branded-fulfillment caveat.
'Zepbound® Starting at $1249' homepage tile; same branded-fulfillment caveat.
'Wegovy® Starting at $1579' homepage tile; same branded-fulfillment caveat.
NewSelf
All dosages same price
All dosages same price
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What’s included
TrimRx
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
NewSelf
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
TrimRx
7.7/10
NewSelf
8.3/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | TrimRx | NewSelf |
|---|---|---|
| Starting Price | $179/mo | ✓$100/mo |
| Features | ✓8 features | 6 features |
| States Available | Not disclosed | 49 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | ✓ Yes | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About TrimRx
TrimRx is a telehealth weight-loss program offering compounded semaglutide and tirzepatide prescribed by licensed US medical providers after an online medical-history review, with medication shipped monthly and free shipping. It leans on price stability and dose continuity — "switch and keep your current dose, no price hikes" — and needs no insurance (cash-pay, tiered monthly pricing plus multi-month bundles). Compounded GLP-1s are not FDA-approved. The compounding pharmacy and state list are not published, specifics are gated behind the intake quiz, and no LegitScript certification is shown.
Read our full TrimRx review →About NewSelf
NewSelf offers compounded semaglutide+ (with B12/Glycine, from $99.97/mo) and compounded tirzepatide+ (with B6/Glycine, from $144.49/mo). LegitScript certified. Available in 48 states + Puerto Rico. Uses 503A licensed pharmacies with third-party testing.
Read our full NewSelf review →Pros & Cons
TrimRx
What we like
- Compounded semaglutide and tirzepatide, both prescribed by licensed US medical providers after an online medical-history review
- Free shipping with medication delivered to your door monthly — can start as soon as the next day
- Price-stability positioning: "switch and keep your current dose," with no advertised mid-program price hikes
- Tiered monthly pricing from ~$179/mo plus discounted multi-month bundles; no insurance required (cash-pay)
- 24/7 patient portal for support; publishes HIPAA, privacy, SMS, and terms policies
Watch-outs
- Async, questionnaire-based intake — no mandatory video visit with a clinician before prescribing
- Compounded semaglutide is not FDA-approved (the site discloses this) — it is not brand Wegovy or Ozempic
- Injectable-only — compounded semaglutide and tirzepatide are advertised, no oral form; program specifics are gated behind the intake quiz
- Compounding pharmacy partner is not named, and the state-availability list is not published
- Pricing tiers and program details are gated behind the intake quiz; no LegitScript certification displayed
NewSelf
What we like
- Semaglutide+ from $99.97/mo — among the lowest prices in the dataset
- All dosages at the same price — no price escalation as dose increases
- LegitScript certified with 503A licensed pharmacies
- Third-party potency, sterility, and endotoxicity testing
- 48 states + Puerto Rico coverage
- B12/B6 + Glycine enhanced formulations
- No membership fees
Watch-outs
- Not available in Mississippi and Louisiana
- Compounded only — no brand-name options
- Site also promotes AI health optimization and longevity (broader platform)
Our Verdict
TrimRx is our recommended choice here, particularly for best overall value. NewSelf is a solid alternative, especially if you want lowest-cost compounded GLP-1 with pharmacy quality transparency — compare the six-dimension breakdown and pricing below to weigh them for your situation.
Choose NewSelf if…
You want lowest-cost compounded GLP-1 with pharmacy quality transparency and a starting price around $100/mo.
Ready to start? Vetted GLP-1 providers
Vetted telehealth providers that prescribe GLP-1 online.
No insurance needed · vetted by our editors
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Synergy Rx
Broadest drug catalog in the Lion MD white-label cluster
From $199/mo
Get started →RxSpan MD
Shoppers wanting physician-led, pharmacy-transparent compounded GLP-1 with brand-name options
From $179/mo
Get started →Strut Health
Oral-lozenge compounded GLP-1 access
From $99/mo
Get started →TrimRx vs NewSelf: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
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