PrescrYbe vs NewSelf
An in-depth comparison of two leading GLP-1 Providers
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PrescrYbe
Best for: shoppers who want an oral GLP-1 option or a low-dose microdosing tier
Visit PrescrYbe →
NewSelf
Best for: lowest-cost compounded GLP-1 with pharmacy quality transparency
Visit NewSelf →PrescrYbe and NewSelf are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, NewSelf starts lower at $100/mo versus $179/mo, and NewSelf edges ahead overall (8.3 vs 7.3 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
PrescrYbe
Card reads "$249 per 4 week". A 4-week cycle is 13 charges a year, not 12 — the site states the cadence openly.
Card reads "$339 per 4 week".
Card reads "$279 per 4 week" for the oral formulation.
Low-dose tier, "$179 per 4 week".
Low-dose tier, "$179 per 4 week".
NewSelf
All dosages same price
All dosages same price
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What’s included
PrescrYbe
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
NewSelf
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
PrescrYbe
7.3/10
NewSelf
8.3/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | PrescrYbe | NewSelf |
|---|---|---|
| Starting Price | $179/mo | ✓$100/mo |
| Features | 6 features | 6 features |
| States Available | Not disclosed | 49 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | ✓None | 1 warning |
About PrescrYbe
PrescrYbe is a cash-pay telehealth platform offering compounded semaglutide and tirzepatide as injections or an oral formulation, plus low-dose microdosing tiers from $179. Pricing is billed every 4 weeks rather than monthly and the cadence is stated on the product card. Consultations, medication and shipping are bundled into one price, and you are not charged if a provider finds you ineligible.
Read our full PrescrYbe review →About NewSelf
NewSelf offers compounded semaglutide+ (with B12/Glycine, from $99.97/mo) and compounded tirzepatide+ (with B6/Glycine, from $144.49/mo). LegitScript certified. Available in 48 states + Puerto Rico. Uses 503A licensed pharmacies with third-party testing.
Read our full NewSelf review →Pros & Cons
PrescrYbe
What we like
- Five GLP-1 tiers including an oral semaglutide option and $179 microdosing for both drugs
- Billing cadence is printed on the product card — most sites hide the 4-week cycle
- Price shown before you start intake, not after
- Consultation, medication and shipping bundled into one cash-pay price
- Full refund if a provider finds you ineligible: "If you don't qualify, you don't pay"
Watch-outs
- Charged every 4 weeks, so a year costs 13 payments, not 12 — $3,237/yr on semaglutide, not $2,988
- Neither the prescribing medical group nor the pharmacy partner is named anywhere in the terms
- No published state list — terms say only that some services may not be available in all states
- Cancellation is by email to care@prescrybe.health; no self-serve cancel is documented
- No support phone number published
- Compounded only, and the terms confirm compounded drugs are not FDA approved
NewSelf
What we like
- Semaglutide+ from $99.97/mo — among the lowest prices in the dataset
- All dosages at the same price — no price escalation as dose increases
- LegitScript certified with 503A licensed pharmacies
- Third-party potency, sterility, and endotoxicity testing
- 48 states + Puerto Rico coverage
- B12/B6 + Glycine enhanced formulations
- No membership fees
Watch-outs
- Not available in Mississippi and Louisiana
- Compounded only — no brand-name options
- Site also promotes AI health optimization and longevity (broader platform)
Our Verdict
NewSelf edges out PrescrYbe with a higher overall score of 8.3/10 and is particularly strong for lowest-cost compounded GLP-1 with pharmacy quality transparency. PrescrYbe remains a solid alternative, especially if you're looking for shoppers who want an oral GLP-1 option or a low-dose microdosing tier.
Choose PrescrYbe if…
You want shoppers who want an oral GLP-1 option or a low-dose microdosing tier and a starting price around $179/mo.
Choose NewSelf if…
You want lowest-cost compounded GLP-1 with pharmacy quality transparency and a starting price around $100/mo.
Ready to start? Vetted GLP-1 providers
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MEDVi
Switching between compounded and brand-name GLP-1 through one provider
From $99/mo
Get started →Liv Body
Compounded GLP-1 paired with a muscle-preservation supplement stack
From $99/mo
Get started →DudeMeds
Men seeking no-fee GLP-1 access with oral and injectable options
From $175/mo
Get started →PrescrYbe vs NewSelf: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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