PrescrYbe vs Amazon One Medical
An in-depth comparison of two leading GLP-1 Providers
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PrescrYbe
Best for: shoppers who want an oral GLP-1 option or a low-dose microdosing tier
Visit PrescrYbe →
Amazon One Medical
Best for: the most authoritative brand-name GLP-1 channel, with same-day delivery
Visit Amazon One Medical →PrescrYbe and Amazon One Medical are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, Amazon One Medical starts lower at $149/mo versus $179/mo, and Amazon One Medical edges ahead overall (8.5 vs 7.3 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
PrescrYbe
Card reads "$249 per 4 week". A 4-week cycle is 13 charges a year, not 12 — the site states the cadence openly.
Card reads "$339 per 4 week".
Card reads "$279 per 4 week" for the oral formulation.
Low-dose tier, "$179 per 4 week".
Low-dose tier, "$179 per 4 week".
Amazon One Medical
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What’s included
PrescrYbe
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Amazon One Medical
What the monthly price covers
Medication
Billed separately
Provider visits
Included
Shipping
Included
Lab work
Billed separately
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
PrescrYbe
7.3/10
Amazon One Medical
8.5/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | PrescrYbe | Amazon One Medical |
|---|---|---|
| Starting Price | $179/mo | ✓$149/mo |
| Features | 6 features | 6 features |
| States Available | Not disclosed | 50 |
| Compounded | ✓ Yes | — |
| Brand Name | — | ✓ Yes |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About PrescrYbe
PrescrYbe is a cash-pay telehealth platform offering compounded semaglutide and tirzepatide as injections or an oral formulation, plus low-dose microdosing tiers from $179. Pricing is billed every 4 weeks rather than monthly and the cadence is stated on the product card. Consultations, medication and shipping are bundled into one price, and you are not charged if a provider finds you ineligible.
Read our full PrescrYbe review →About Amazon One Medical
Amazon One Medical is the unified Amazon GLP-1 channel — One Medical clinicians prescribe FDA-approved Wegovy, Zepbound, and Foundayo (no compounded products), and Amazon Pharmacy fulfills with same-day delivery across roughly 3,000 US cities plus pickup kiosks at select One Medical locations. No prior membership required; insurance and cash pay both accepted. Foundayo launched at $25/month with insurance and the Lilly Savings Card, or $149/month cash pay.
Read our full Amazon One Medical review →Pros & Cons
PrescrYbe
What we like
- Five GLP-1 tiers including an oral semaglutide option and $179 microdosing for both drugs
- Billing cadence is printed on the product card — most sites hide the 4-week cycle
- Price shown before you start intake, not after
- Consultation, medication and shipping bundled into one cash-pay price
- Full refund if a provider finds you ineligible: "If you don't qualify, you don't pay"
Watch-outs
- Charged every 4 weeks, so a year costs 13 payments, not 12 — $3,237/yr on semaglutide, not $2,988
- Neither the prescribing medical group nor the pharmacy partner is named anywhere in the terms
- No published state list — terms say only that some services may not be available in all states
- Cancellation is by email to care@prescrybe.health; no self-serve cancel is documented
- No support phone number published
- Compounded only, and the terms confirm compounded drugs are not FDA approved
Amazon One Medical
What we like
- As low as $1/day ($25/month) for brand-name Foundayo with insurance and the auto-applied Lilly coupon
- Same-day delivery in nearly 3,000 US cities at launch, expanding to 4,500 by end of 2026
- In-office pharmacist kiosks at select One Medical clinics let you walk out with Foundayo in hand
- Cash-pay $5/day ($149/month) is competitive for the same FDA-approved brand-name product
- Real-time availability, transparent pricing, and automatic manufacturer coupon at checkout
- Delivering GLP-1 medications since 2021 — track record on cold-chain logistics
Watch-outs
- Headline $25/month needs both insurance and the Lilly Savings Card — uninsured pay $149/month
- Same-day delivery is geographically gated; outside major cities it drops to next-day or slower
- Pricing is set by manufacturer savings programs and can change at any time
- No compounded options — brand-name only (Foundayo, Wegovy, Zepbound)
- Wegovy/Zepbound pricing isn't shown upfront — depends on insurance at the prescribing visit
- Copays and deductibles still apply to the clinical visit
Our Verdict
Amazon One Medical edges out PrescrYbe with a higher overall score of 8.5/10 and is particularly strong for the most authoritative brand-name GLP-1 channel, with same-day delivery. PrescrYbe remains a solid alternative, especially if you're looking for shoppers who want an oral GLP-1 option or a low-dose microdosing tier.
Choose PrescrYbe if…
You want shoppers who want an oral GLP-1 option or a low-dose microdosing tier and a starting price around $179/mo.
Choose Amazon One Medical if…
You want the most authoritative brand-name GLP-1 channel, with same-day delivery and a starting price around $149/mo.
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LegitScript-certified compounded GLP-1 via named pharmacies
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LGBTQ+-inclusive compounded GLP-1 telehealth
From $199/mo
Get started →Enhance MD
Lab-monitored compounded GLP-1 with mandatory video visit
From $112/mo
Get started →PrescrYbe vs Amazon One Medical: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.