OnlyRx vs NewSelf
An in-depth comparison of two leading GLP-1 Providers
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OnlyRx
Best for: compounded GLP-1 in oral-tablet and injection with named prescribers
Visit OnlyRx →
NewSelf
Best for: lowest-cost compounded GLP-1 with pharmacy quality transparency
Visit NewSelf →OnlyRx and NewSelf are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, NewSelf starts lower at $100/mo versus $179/mo, and NewSelf edges ahead overall (8.3 vs 6.4 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
OnlyRx
NewSelf
All dosages same price
All dosages same price
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What’s included
OnlyRx
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
NewSelf
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
OnlyRx
6.4/10
NewSelf
8.3/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | OnlyRx | NewSelf |
|---|---|---|
| Starting Price | $179/mo | ✓$100/mo |
| Features | ✓8 features | 6 features |
| States Available | Not disclosed | 49 |
| Compounded | — | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About OnlyRx
OnlyRx is a cash-pay GLP-1 telehealth platform offering compounded semaglutide and tirzepatide in both injection and oral disintegrating tablet (ODT) forms — an uncommon needle-free option. It names its prescribers and a four-pharmacy fulfillment network, and offers brand-name GLP-1s when prescribed. Available in all 50 states with Buy Now Pay Later; compounded semaglutide injection starts at $179/mo on a summer promo.
Read our full OnlyRx review →About NewSelf
NewSelf offers compounded semaglutide+ (with B12/Glycine, from $99.97/mo) and compounded tirzepatide+ (with B6/Glycine, from $144.49/mo). LegitScript certified. Available in 48 states + Puerto Rico. Uses 503A licensed pharmacies with third-party testing.
Read our full NewSelf review →Pros & Cons
OnlyRx
What we like
- Four-pharmacy network: Belmar, Strive, Epiq Scripts, and Casa Pharma RX
- Named prescribers on the public site: Dr. Carr (MD), Dr. Tenbrink (MD), Dr. Italia (MD), Dr. Mansour (DO)
- Oral disintegrating tablet (ODT) form for both semaglutide and tirzepatide — good for needle-averse patients
- Pricing, drug list, pharmacy partners, and physician roster all visible on the public site
- LegitScript Certified
- Brand-name Ozempic, Wegovy, Zepbound, and Mounjaro available alongside the compounded line
Watch-outs
- Promo pricing ($179 semaglutide injection) is prominent, but post-promo maintenance pricing isn't shown
- No titration-ladder pricing — you can't see costs at 1.0 mg or 2.4 mg maintenance
- Refund / cancellation policy not stated on the homepage
- Lab-work requirement not stated
- Operating corporate entity not disclosed
- Epiq Scripts is the one named pharmacy partner not yet independently verified
NewSelf
What we like
- Semaglutide+ from $99.97/mo — among the lowest prices in the dataset
- All dosages at the same price — no price escalation as dose increases
- LegitScript certified with 503A licensed pharmacies
- Third-party potency, sterility, and endotoxicity testing
- 48 states + Puerto Rico coverage
- B12/B6 + Glycine enhanced formulations
- No membership fees
Watch-outs
- Not available in Mississippi and Louisiana
- Compounded only — no brand-name options
- Site also promotes AI health optimization and longevity (broader platform)
Our Verdict
NewSelf edges out OnlyRx with a higher overall score of 8.3/10 and is particularly strong for lowest-cost compounded GLP-1 with pharmacy quality transparency. OnlyRx remains a solid alternative, especially if you're looking for compounded GLP-1 in oral-tablet and injection with named prescribers.
Choose OnlyRx if…
You want compounded GLP-1 in oral-tablet and injection with named prescribers and a starting price around $179/mo.
Choose NewSelf if…
You want lowest-cost compounded GLP-1 with pharmacy quality transparency and a starting price around $100/mo.
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Synergy Rx
Broadest drug catalog in the Lion MD white-label cluster
From $199/mo
Get started →RxSpan MD
Shoppers wanting physician-led, pharmacy-transparent compounded GLP-1 with brand-name options
From $179/mo
Get started →Strut Health
Oral-lozenge compounded GLP-1 access
From $99/mo
Get started →OnlyRx vs NewSelf: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.