NewSelf vs Rex MD
An in-depth comparison of two leading GLP-1 Providers
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NewSelf
Best for: lowest-cost compounded GLP-1 with pharmacy quality transparency
Visit NewSelf →
Rex MD
Best for: Men wanting a flat-fee, all-inclusive branded GLP-1 program nationwide
Visit Rex MD →NewSelf and Rex MD are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, NewSelf starts lower at $100/mo versus $349/mo, and NewSelf edges ahead overall (8.3 vs 7.2 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
NewSelf
All dosages same price
All dosages same price
Rex MD
Advertised flat program fee; not on the current weight-management page.
Includes provider care. Rex MD prices this and nothing else on its weight-management page; the Zepbound vial product is in the nav with no published price.
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What’s included
NewSelf
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Rex MD
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
NewSelf
8.3/10
Rex MD
7.2/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | NewSelf | Rex MD |
|---|---|---|
| Starting Price | ✓$100/mo | $349/mo |
| Features | 6 features | ✓8 features |
| States Available | 49 | ✓50 |
| Compounded | ✓ Yes | — |
| Brand Name | — | ✓ Yes |
| FSA/HSA Accepted | — | — |
| FDA Warnings | 1 warning | ✓None |
About NewSelf
NewSelf offers compounded semaglutide+ (with B12/Glycine, from $99.97/mo) and compounded tirzepatide+ (with B6/Glycine, from $144.49/mo). LegitScript certified. Available in 48 states + Puerto Rico. Uses 503A licensed pharmacies with third-party testing.
Read our full NewSelf review →About Rex MD
Rex MD is a US-based men's-health telehealth platform (a LifeMD brand) offering a 100 percent online GLP-1 weight-management program. It prescribes brand-name semaglutide and Zepbound (tirzepatide) vials, filled through partner pharmacies. The flat monthly program runs about $199 and includes the medical intake, provider consultations, prescribed medication, syringes and free overnight shipping; Zepbound vials start around $349 per month. Providers are US-based, state-licensed clinicians and the platform is LegitScript certified. Rex MD serves all 50 states and does not bill insurance.
Read our full Rex MD review →Pros & Cons
NewSelf
What we like
- Semaglutide+ from $99.97/mo — among the lowest prices in the dataset
- All dosages at the same price — no price escalation as dose increases
- LegitScript certified with 503A licensed pharmacies
- Third-party potency, sterility, and endotoxicity testing
- 48 states + Puerto Rico coverage
- B12/B6 + Glycine enhanced formulations
- No membership fees
Watch-outs
- Not available in Mississippi and Louisiana
- Compounded only — no brand-name options
- Site also promotes AI health optimization and longevity (broader platform)
Rex MD
What we like
- Flat $199/mo program bundles consult, medication and overnight shipping
- Brand-name semaglutide and Zepbound vials, not just compounded
- Serves all 50 states, fully online
- LegitScript certified with US-based, state-licensed providers
- Backed by parent company LifeMD
Watch-outs
- Does not accept insurance
- Marketed primarily to men via a men's-health platform
- Zepbound vial cost rises with dose titration
- Branded-only program costs more than compounded options
Our Verdict
NewSelf edges out Rex MD with a higher overall score of 8.3/10 and is particularly strong for lowest-cost compounded GLP-1 with pharmacy quality transparency. Rex MD remains a solid alternative, especially if you're looking for Men wanting a flat-fee, all-inclusive branded GLP-1 program nationwide.
Choose NewSelf if…
You want lowest-cost compounded GLP-1 with pharmacy quality transparency and a starting price around $100/mo.
Choose Rex MD if…
You want Men wanting a flat-fee, all-inclusive branded GLP-1 program nationwide and a starting price around $349/mo.
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RxSpan MD
Physician-led, pharmacy-transparent compounded GLP-1 with brand-name options
From $179/mo
Get started →Strut Health
Oral-lozenge compounded GLP-1 access
From $99/mo
Get started →Yucca Health
Mainstream telehealth GLP-1 access
From $146/mo
Get started →NewSelf vs Rex MD: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.