NewSelf vs PlexusDx
Our featured pick: PlexusDx (affiliate partner). In our scoring, NewSelf scores 8.2 and PlexusDx 7.0 out of 10.
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Key differences
- Price
- NewSelf $100/mo on a 3-month prepaid plan; PlexusDx $129/mo no prepay listed (compounded semaglutide · not like-for-like, so neither is marked cheaper)
- Coverage
- NewSelf 48 states + PR; PlexusDx 50 states (only NewSelf: PR · only PlexusDx: Louisiana and Mississippi)
- Included
- NewSelf: medication, clinician visits, shipping; PlexusDx: medication, clinician visits
- Safety
- FDA warning letters on record: NewSelf 1, PlexusDx none
NewSelf
Best for lowest-cost compounded GLP-1 at one price for every dose, if a 3-month commitment works for you
semaglutide
$100
on a 3-month prepaid plan
Our score 8.2/10
PlexusDx
Affiliate partnerBest for nationwide compounded GLP-1 with optional genetic-test personalization
semaglutide
$129
microdose plan
Our score 7.0/10
We may earn a commission if you sign up through these links. Partner status can affect which provider we feature; it never changes a score or a price.
Costs & coverage
Published prices with their terms attached. Yearly figures are modeled from the standing price and billing cadence. A check mark marks the better side, on like-for-like rows only.
NewSelf
PlexusDx
Price
Semaglutide / month
$100/mo
on a 3-month prepaid plan
$129/mo
microdose plan
Semaglutide / year (modeled)
$1,200
$1,548
Tirzepatide / month
$144/mo
on a 3-month prepaid plan
$249/mo
starting dose
Tirzepatide / year (modeled)
$1,728
$2,988
Coverage
State availability
48 states + PR
50 states
Included in the price
Medication, clinician visits, shipping
Medication, clinician visits
Terms & safety
Price shown
Before intake
Before intake
Cancel anytime
No
Not disclosed
Minimum commitment
3-month plan for the listed price
Not disclosed
Refunds
No refunds after the doctor visit; full refund if the doctor declines; $99 fee if you cancel before the visit
Not disclosed
Early-cancellation fee
Yes
Not disclosed
FDA warning letters
1 warning letter
Better on this row: None on record
Provider facts checked
October 2026
August 2026
Show where they differ by stateHide state lists
Only NewSelf (PR)
- PR
Only PlexusDx (2 states)
- Louisiana
- Mississippi
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Which fits your priorities?
Only the points where these two differ, from the table above and each provider’s record.
Choose NewSelf if…
- Serves PR, where PlexusDx doesn't
- Same price at every dose, so your bill doesn't rise as you titrate up
- No membership fee; the visit, medication and shipping are bundled
What to weigh up
- 1 FDA warning letter on record
- Its $100/mo compounded semaglutide price needs a 3-month prepaid plan
Choose PlexusDx if…
- Its $129/mo compounded semaglutide price needs no prepay; NewSelf's $100 needs a 3-month prepay
- Serves Louisiana and Mississippi, where NewSelf doesn't
- No FDA warning letters on record (NewSelf has 1)
What to weigh up
- Not available in PR
- Compounded medications only; no FDA-approved brand options
Explore the scoring factors
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
NewSelf
8.2/10
PlexusDx
7.0/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Ready to start? Vetted GLP-1 providers
Vetted telehealth providers that prescribe GLP-1 online.
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From $99/mo (“starting at” price)
Get started →Gala
Compounded semaglutide or tirzepatide at one all-doses price on a yearly plan, with free shipping
Read full review →From $129/mo (starting dose)
Get started →From $249/mo
Get started →NewSelf vs PlexusDx: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking, or alternatives to NewSelf and PlexusDx.
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