NewSelf vs Optimized Health
An in-depth comparison of two leading GLP-1 Providers
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NewSelf
Best for: lowest-cost compounded GLP-1 with pharmacy quality transparency
Visit NewSelf →
Optimized Health
Best for: Patients in MO/IA/KS/UT/WA wanting transparent, lab-guided compounded GLP-1 weight loss
Visit Optimized Health →NewSelf and Optimized Health are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, NewSelf starts lower at $100/mo versus $200/mo, and NewSelf edges ahead overall (8.3 vs 7.3 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
NewSelf
All dosages same price
All dosages same price
Optimized Health
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What’s included
NewSelf
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Optimized Health
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Not disclosed
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
NewSelf
8.3/10
Optimized Health
7.3/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | NewSelf | Optimized Health |
|---|---|---|
| Starting Price | ✓$100/mo | $200/mo |
| Features | 6 features | ✓8 features |
| States Available | ✓49 | 5 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | ✓ Yes |
| FDA Warnings | None | None |
About NewSelf
NewSelf offers compounded semaglutide+ (with B12/Glycine, from $99.97/mo) and compounded tirzepatide+ (with B6/Glycine, from $144.49/mo). LegitScript certified. Available in 48 states + Puerto Rico. Uses 503A licensed pharmacies with third-party testing.
Read our full NewSelf review →About Optimized Health
Optimized Health is a concierge medical weight loss and hormone clinic offering clinician-supervised GLP-1 programs with compounded semaglutide and tirzepatide, plus oral options like phentermine. Care is delivered via telehealth in Missouri, Iowa, Kansas, Utah, and Washington, or in person in Joplin, MO. Pricing is published openly: semaglutide from $200/month and tirzepatide from $250/month, with lab panels included, meds shipped to the door, and receipts for HSA/FSA reimbursement. The clinic is LegitScript certified and led by Mathew Hammons, PA-C, with over a decade in obesity medicine.
Read our full Optimized Health review →Pros & Cons
NewSelf
What we like
- Semaglutide+ from $99.97/mo — among the lowest prices in the dataset
- All dosages at the same price — no price escalation as dose increases
- LegitScript certified with 503A licensed pharmacies
- Third-party potency, sterility, and endotoxicity testing
- 48 states + Puerto Rico coverage
- B12/B6 + Glycine enhanced formulations
- No membership fees
Watch-outs
- Not available in Mississippi and Louisiana
- Compounded only — no brand-name options
- Site also promotes AI health optimization and longevity (broader platform)
Optimized Health
What we like
- Fully transparent pricing published on the website
- Semaglutide from $200/mo and tirzepatide from $250/mo
- Lab panels included with clinician-supervised dosing
- LegitScript certified clinic
- Lead PA-C with over a decade in obesity medicine
- HSA/FSA receipts provided and medications shipped home
Watch-outs
- Telehealth limited to MO, IA, KS, UT, and WA
- Compounded GLP-1 only, not brand-name
- No insurance billing (cash-pay)
- PA-led rather than MD/DO-led
Our Verdict
NewSelf edges out Optimized Health with a higher overall score of 8.3/10 and is particularly strong for lowest-cost compounded GLP-1 with pharmacy quality transparency. Optimized Health remains a solid alternative, especially if you're looking for Patients in MO/IA/KS/UT/WA wanting transparent, lab-guided compounded GLP-1 weight loss.
Choose NewSelf if…
You want lowest-cost compounded GLP-1 with pharmacy quality transparency and a starting price around $100/mo.
Choose Optimized Health if…
You want Patients in MO/IA/KS/UT/WA wanting transparent, lab-guided compounded GLP-1 weight loss and a starting price around $200/mo.
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Get started →NewSelf vs Optimized Health: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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