Metabolic Rx vs Amazon One Medical
An in-depth comparison of two leading GLP-1 Providers
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Metabolic Rx
Best for: people who want a flat price at every dose and can prepay for compounded semaglutide or tirzepatide
Visit Metabolic Rx →
Amazon One Medical
Best for: the most authoritative brand-name GLP-1 channel, with same-day delivery
Visit Amazon One Medical →Metabolic Rx and Amazon One Medical are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, Amazon One Medical starts lower at $149/mo versus $229/mo, and Amazon One Medical edges ahead overall (8.5 vs 6.3 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
Metabolic Rx
$159 first month, then $259. A 3-month plan is $449 and a 6-month plan $849, each charged upfront
$149 first month, then $329. A 3-month plan is $597 and a 6-month plan $1,099, each charged upfront
$149 first month, then $229. Prepaid plans are shown at $166 a month for 3 months and $149 a month for 6 months
Amazon One Medical
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What’s included
Metabolic Rx
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Included
Amazon One Medical
What the monthly price covers
Medication
Billed separately
Provider visits
Included
Shipping
Included
Lab work
Billed separately
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Metabolic Rx
6.3/10
Amazon One Medical
8.5/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | Metabolic Rx | Amazon One Medical |
|---|---|---|
| Starting Price | $229/mo | ✓$149/mo |
| Features | ✓7 features | 6 features |
| States Available | Not disclosed | 50 |
| Compounded | ✓ Yes | — |
| Brand Name | — | ✓ Yes |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About Metabolic Rx
Metabolic Rx is a telehealth platform launched in 2026 that sells compounded semaglutide and tirzepatide injections and a daily oral semaglutide, with one flat price at every dose. Monthly plans renew at $259 for semaglutide and $329 for tirzepatide after a discounted first month of $159 or $149. The company does not name its medical group, pharmacies or the business behind it.
Read our full Metabolic Rx review →About Amazon One Medical
Amazon One Medical is the unified Amazon GLP-1 channel — One Medical clinicians prescribe FDA-approved Wegovy, Zepbound, and Foundayo (no compounded products), and Amazon Pharmacy fulfills with same-day delivery across roughly 3,000 US cities plus pickup kiosks at select One Medical locations. No prior membership required; insurance and cash pay both accepted. Foundayo launched at $25/month with insurance and the Lilly Savings Card, or $149/month cash pay.
Read our full Amazon One Medical review →Pros & Cons
Metabolic Rx
What we like
- One flat price at every dose, with medication, physician review, coaching and shipping included
- Discounted first month: $159 for semaglutide and $149 for tirzepatide
- Prepaying lowers semaglutide to about $142 to $150 a month and tirzepatide to $183 to $199 a month
- Offers a daily oral semaglutide option as well as weekly injections
- Refund if the prescribing clinician declines treatment or the order has not shipped
- Publishes a support phone number with weekday hours
Watch-outs
- The site does not name the company behind it, its medical group or the pharmacies that fill prescriptions
- Its privacy policy lists a placeholder mailing address rather than a real one
- Monthly plans renew at $259 for semaglutide and $329 for tirzepatide after the discounted first month
- The intake says you are approved before any clinician reviews it, then runs a 15-minute countdown at checkout
- You pay at checkout before a physician reviews your answers, and you must agree to calls and texts to continue
- The 3- and 6-month plans are charged upfront, though checkout says you pay one month at a time
- Its Trustpilot and Google rating badges could not be traced; there is no Trustpilot profile or LegitScript seal
- The cancellation notice period is unclear: 48 hours in the terms but 30 days in the FAQ
Amazon One Medical
What we like
- As low as $1/day ($25/month) for brand-name Foundayo with insurance and the auto-applied Lilly coupon
- Same-day delivery in nearly 3,000 US cities at launch, expanding to 4,500 by end of 2026
- In-office pharmacist kiosks at select One Medical clinics let you walk out with Foundayo in hand
- Cash-pay $5/day ($149/month) is competitive for the same FDA-approved brand-name product
- Real-time availability, transparent pricing, and automatic manufacturer coupon at checkout
- Delivering GLP-1 medications since 2021 — track record on cold-chain logistics
Watch-outs
- Headline $25/month needs both insurance and the Lilly Savings Card — uninsured pay $149/month
- Same-day delivery is geographically gated; outside major cities it drops to next-day or slower
- Pricing is set by manufacturer savings programs and can change at any time
- No compounded options — brand-name only (Foundayo, Wegovy, Zepbound)
- Wegovy/Zepbound pricing isn't shown upfront — depends on insurance at the prescribing visit
- Copays and deductibles still apply to the clinical visit
Our Verdict
Amazon One Medical edges out Metabolic Rx with a higher overall score of 8.5/10 and is particularly strong for the most authoritative brand-name GLP-1 channel, with same-day delivery. Metabolic Rx remains a solid alternative, especially if you're looking for people who want a flat price at every dose and can prepay for compounded semaglutide or tirzepatide.
Choose Metabolic Rx if…
You want people who want a flat price at every dose and can prepay for compounded semaglutide or tirzepatide and a starting price around $229/mo.
Choose Amazon One Medical if…
You want the most authoritative brand-name GLP-1 channel, with same-day delivery and a starting price around $149/mo.
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Found
Mainstream telehealth GLP-1 access
From $99/mo
Get started →Oak
Compounded semaglutide and tirzepatide at a flat monthly price
From $133/mo
Get started →Bodybuilding Health+
Fitness-brand compounded GLP-1 with hormone and performance programs
From $179/mo
Get started →Metabolic Rx vs Amazon One Medical: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.