Lttl vs NewSelf
An in-depth comparison of two leading GLP-1 Providers
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Lttl
Best for: shoppers who want every commitment tier priced openly, plus a low-dose microdose option
Visit Lttl →
NewSelf
Best for: lowest-cost compounded GLP-1 with pharmacy quality transparency
Visit NewSelf →Lttl and NewSelf are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, NewSelf starts lower at $100/mo versus $149/mo, and NewSelf edges ahead overall (8.3 vs 7.2 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
Lttl
Month-to-month 'Monthly Auto-Refill' rate, was $249. Commitment ladder published on /plans: $169/mo billed $507 quarterly, $149/mo billed $894 every 6mo, $129/mo billed $1,548 annually. Promo is a one-time 'First Month Special' at $149 ('$149 - first month only'). The homepage 'Plans start at $129/mo' headline is the 12-month prepay rate.
Month-to-month rate, was $339. Ladder: $249/mo billed $747 quarterly, $229/mo billed $1,374 every 6mo, $199/mo billed $2,388 annually. One-time First Month Special $199. The '$199 per month' figure advertised on /weight-loss is the 12-month prepay rate.
Needle-free oral option. Month-to-month, was $279. Ladder: $199 quarterly, $179 every 6mo, $159 annually. First Month Special $179.
Low-dose line marketed for tolerability. Month-to-month, was $179. Ladder: $129 quarterly, $119 every 6mo, $109 annually. First Month Special $119.
Low-dose GLP-1 + GIP. Same ladder as microdose semaglutide: $129 quarterly, $119 every 6mo, $109 annually. First Month Special $119.
Month-to-month, was $209. Ladder: $159 quarterly, $149 every 6mo, $139 annually. First Month Special $149.
NewSelf
All dosages same price
All dosages same price
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What’s included
Lttl
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
NewSelf
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Lttl
7.2/10
NewSelf
8.3/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | Lttl | NewSelf |
|---|---|---|
| Starting Price | $149/mo | ✓$100/mo |
| Features | ✓8 features | 6 features |
| States Available | Not disclosed | 49 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | ✓ Yes | — |
| FDA Warnings | None | None |
About Lttl
Lttl (pronounced 'little') is a direct-to-consumer telehealth brand offering compounded semaglutide and tirzepatide, a low-dose 'microdose' line, and longevity peptides. It publishes its full price matrix — every medication, form and commitment length — before checkout, and bills one flat rate regardless of dose. Month-to-month compounded semaglutide is $199/mo and tirzepatide $279/mo, dropping to $129 and $199 on a 12-month prepay.
Read our full Lttl review →About NewSelf
NewSelf offers compounded semaglutide+ (with B12/Glycine, from $99.97/mo) and compounded tirzepatide+ (with B6/Glycine, from $144.49/mo). LegitScript certified. Available in 48 states + Puerto Rico. Uses 503A licensed pharmacies with third-party testing.
Read our full NewSelf review →Pros & Cons
Lttl
What we like
- Publishes the full price matrix — every medication, form and commitment length — on a public /plans page before checkout
- Flat dose pricing: 'Same price at every dose,' so moving to a higher dose does not raise the monthly bill
- States plainly that its compounded GLP-1s 'are not FDA-approved and have not been evaluated by the FDA for safety, efficacy, or quality'
- Microdose line prices low-dose semaglutide or tirzepatide at $149/mo month-to-month for people sensitive to side effects
- Oral ODT semaglutide offered for members who want to avoid injections
- Cancel anytime with no contract, plus a full refund if a provider finds you medically ineligible at the initial consultation
- Free shipping with cold-chain packaging and tracking; HSA and FSA funds accepted
Watch-outs
- Partner pharmacies are never named — the site refers only to 'a partner U.S. pharmacy' (a material disclosure gap for a YMYL purchase)
- The advertised 'Plans start at $129/mo' is the 12-month prepay rate; true month-to-month is $199 semaglutide and $279 tirzepatide
- No public list of states served — eligibility depends on where unnamed 'partner providers are licensed'
- Site banner promises 'Prescribed and shipped within 48 hours' while the shipping policy states 2-5 business days to process plus 3-7 to deliver
- Medications cannot be returned or refunded once they ship from the pharmacy
- Does not bill insurance; consultation and medication are entirely out of pocket
- Terms impose mandatory individual arbitration and waive class actions
- Footer links to LegitScript but no certification record is published for the domain
NewSelf
What we like
- Semaglutide+ from $99.97/mo — among the lowest prices in the dataset
- All dosages at the same price — no price escalation as dose increases
- LegitScript certified with 503A licensed pharmacies
- Third-party potency, sterility, and endotoxicity testing
- 48 states + Puerto Rico coverage
- B12/B6 + Glycine enhanced formulations
- No membership fees
Watch-outs
- Not available in Mississippi and Louisiana
- Compounded only — no brand-name options
- Site also promotes AI health optimization and longevity (broader platform)
Our Verdict
NewSelf edges out Lttl with a higher overall score of 8.3/10 and is particularly strong for lowest-cost compounded GLP-1 with pharmacy quality transparency. Lttl remains a solid alternative, especially if you're looking for shoppers who want every commitment tier priced openly, plus a low-dose microdose option.
Choose Lttl if…
You want shoppers who want every commitment tier priced openly, plus a low-dose microdose option and a starting price around $149/mo.
Choose NewSelf if…
You want lowest-cost compounded GLP-1 with pharmacy quality transparency and a starting price around $100/mo.
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Brightmeds
Compounded or brand GLP-1 bundled with TRT and peptides for men
From $100/mo
Get started →Direct Meds
Listed for transparent disclosure — see FDA warning and BBB complaint pattern before considering
From $249/mo
Get started →Maximus
Men seeking compounded GLP-1 alongside testosterone optimization
From $199.99/mo
Get started →Lttl vs NewSelf: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
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