He & She MD vs NewSelf
An in-depth comparison of two leading GLP-1 Providers
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He & She MD
Best for: Cheapest per-month GLP-1 if you can prepay a full year
Visit He & She MD →
NewSelf
Best for: lowest-cost compounded GLP-1 with pharmacy quality transparency
Visit NewSelf →He & She MD and NewSelf are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, He & She MD starts lower at $99/mo versus $100/mo, and He & She MD is the option we'd start with for most patients. Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
He & She MD
Annual plan: billed $1,188 upfront. Advertised as a limited-time rate (banner: 'Injectable Semaglutide $199/month from just $99/month').
Billed $834 every 6 months, saving $360 vs monthly. Homepage GLP-1 Platinum starter rate: $139/mo for the first 6 months, then renews at $1,194 per 6 months, equivalent to $199/mo.
Billed $447 every 3 months, saving $270 vs monthly.
Billed monthly; the standing rate every term plan discounts from.
GLP-1 Platinum oral: $199/mo for the first 6 months, then renews at $1,434 per 6 months, equivalent to $239/mo. Oral is not on the /weight-loss/plans term ladder; figures from the homepage program cards and footnote 3.
Annual plan: billed $1,908 upfront.
Billed $1,194 every 6 months, saving $540 vs monthly. Homepage GLP-1 Platinum starter rate: $199/mo to start, then renews at $1,734 per 6 months, equivalent to $289/mo.
Billed $627 every 3 months, saving $270 vs monthly.
Billed monthly; the standing rate.
NewSelf
All dosages same price
All dosages same price
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What’s included
He & She MD
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Included
NewSelf
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
He & She MD
7.5/10
NewSelf
8.3/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | He & She MD | NewSelf |
|---|---|---|
| Starting Price | ✓$99/mo | $100/mo |
| Features | ✓8 features | 6 features |
| States Available | ✓50 | 49 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | ✓None | 1 warning |
About He & She MD
He & She MD is a nationwide cash-pay telehealth clinic prescribing compounded semaglutide and tirzepatide, injectable or oral, plus brand-name access to Ozempic, Wegovy and Zepbound. Injectable semaglutide is $199/month billed monthly, falling to $139 on a six-month plan and $99 on the annual plan, prepaid for the year; tirzepatide runs $299/month down to $159 annually. Plans bundle medication, injection supplies, free shipping, unlimited provider messaging and GLP-1 coaching, and you are charged only if a clinician prescribes. Ships everywhere except Louisiana. LegitScript-certified.
Read our full He & She MD review →About NewSelf
NewSelf offers compounded semaglutide+ (with B12/Glycine, from $99.97/mo) and compounded tirzepatide+ (with B6/Glycine, from $144.49/mo). LegitScript certified. Available in 48 states + Puerto Rico. Uses 503A licensed pharmacies with third-party testing.
Read our full NewSelf review →Pros & Cons
He & She MD
What we like
- Injectable semaglutide from $99/month on the annual plan, or $139/month on a six-month plan
- Compounded semaglutide and tirzepatide, injectable or oral, plus brand access to Ozempic, Wegovy, Zepbound
- Only charged if medication is prescribed, and no membership fees
- Every plan includes medication, injection supplies, free shipping and unlimited provider messaging
- GLP-1 coaching, nutrition guidance, and in-app progress tracking
- LegitScript-certified, and it names both compounding pharmacies it uses
- Ships to 49 states (all except Louisiana)
Watch-outs
- Compounded GLP-1s are not FDA-approved finished products (per the site FDA disclaimer)
- Does not ship to Louisiana or to PO boxes
- The $99 and $159 headline rates require a full year prepaid in a single charge
- Month-to-month costs $199 for semaglutide and $299 for tirzepatide, roughly double the annual rate
- Six-month starter rates step up on renewal: semaglutide $139 to $199, tirzepatide $199 to $289
- Cash-pay model, insurance billing not indicated
NewSelf
What we like
- Semaglutide+ from $99.97/mo — among the lowest prices in the dataset
- All dosages at the same price — no price escalation as dose increases
- LegitScript certified with 503A licensed pharmacies
- Third-party potency, sterility, and endotoxicity testing
- 48 states + Puerto Rico coverage
- B12/B6 + Glycine enhanced formulations
- No membership fees
Watch-outs
- Not available in Mississippi and Louisiana
- Compounded only — no brand-name options
- Site also promotes AI health optimization and longevity (broader platform)
Our Verdict
He & She MD is our recommended choice here, particularly for Cheapest per-month GLP-1 if you can prepay a full year. NewSelf is a solid alternative, especially if you want lowest-cost compounded GLP-1 with pharmacy quality transparency — compare the six-dimension breakdown and pricing below to weigh them for your situation.
Choose He & She MD if…
You want Cheapest per-month GLP-1 if you can prepay a full year and a starting price around $99/mo.
Choose NewSelf if…
You want lowest-cost compounded GLP-1 with pharmacy quality transparency and a starting price around $100/mo.
Ready to start? Vetted GLP-1 providers
Vetted telehealth providers that prescribe GLP-1 online.
No insurance needed · vetted by our editors
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Trimi Health
Budget-conscious shoppers
From $99/mo
Get started →ShedRx
Mainstream telehealth GLP-1 access
From $149/mo
Get started →bmiMD
Mainstream telehealth GLP-1 access
From $99/mo
Get started →He & She MD vs NewSelf: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.