Framework vs NewSelf
An in-depth comparison of two leading GLP-1 Providers
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Framework
Best for: aggressive $25/week pricing with a named 503B pharmacy partner
Visit Framework →
NewSelf
Best for: lowest-cost compounded GLP-1 with pharmacy quality transparency
Visit NewSelf →Framework and NewSelf are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, both start around $100/mo, and NewSelf edges ahead overall (8.3 vs 6.6 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
Framework
NewSelf
All dosages same price
All dosages same price
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What’s included
Framework
What the monthly price covers
Medication
Included
Provider visits
Not disclosed
Shipping
Not disclosed
Lab work
Not disclosed
Coaching
Included
NewSelf
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Framework
6.6/10
NewSelf
8.3/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | Framework | NewSelf |
|---|---|---|
| Starting Price | $100/mo | $100/mo |
| Features | 5 features | ✓6 features |
| States Available | Not disclosed | 49 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About Framework
Framework is a personalized-plan GLP-1 telehealth platform offering compounded semaglutide and tirzepatide with doctor-guided treatment selection. Its standout detail is a named pharmacy partner, The Pharmacy Hub, operating on the FDA-registered 503B outsourcing pathway rather than the patient-specific 503A compounding most direct-to-consumer competitors use. Pricing starts as low as $25/week (roughly $100/mo) with no membership fees.
Read our full Framework review →About NewSelf
NewSelf offers compounded semaglutide+ (with B12/Glycine, from $99.97/mo) and compounded tirzepatide+ (with B6/Glycine, from $144.49/mo). LegitScript certified. Available in 48 states + Puerto Rico. Uses 503A licensed pharmacies with third-party testing.
Read our full NewSelf review →Pros & Cons
Framework
What we like
- Named 503B pharmacy partner (The Pharmacy Hub) disclosed — the FDA-registered outsourcing-facility pathway, distinct from 503A
- Publishes the FDA compounded-medication disclaimer
- $25/week pricing (~$100/mo) is among the most aggressive in the directory
- $0 membership fees
- Phone support published, toll-free (888) 412-0666
- Personalized-plan positioning vs one-size-fits-all marketplaces
Watch-outs
- LegitScript ID / certification not shown on the homepage
- States-served list not disclosed
- Medical director / clinical leadership not disclosed
- Corporate legal entity not disclosed (no footer copyright)
- Governing law / arbitration venue not stated
- Refund / cancellation policy not detailed
- Per-dose pricing tiers not shown (only the 'as low as $25/week' starting tier)
NewSelf
What we like
- Semaglutide+ from $99.97/mo — among the lowest prices in the dataset
- All dosages at the same price — no price escalation as dose increases
- LegitScript certified with 503A licensed pharmacies
- Third-party potency, sterility, and endotoxicity testing
- 48 states + Puerto Rico coverage
- B12/B6 + Glycine enhanced formulations
- No membership fees
Watch-outs
- Not available in Mississippi and Louisiana
- Compounded only — no brand-name options
- Site also promotes AI health optimization and longevity (broader platform)
Our Verdict
NewSelf edges out Framework with a higher overall score of 8.3/10 and is particularly strong for lowest-cost compounded GLP-1 with pharmacy quality transparency. Framework remains a solid alternative, especially if you're looking for aggressive $25/week pricing with a named 503B pharmacy partner.
Choose Framework if…
You want aggressive $25/week pricing with a named 503B pharmacy partner and a starting price around $100/mo.
Choose NewSelf if…
You want lowest-cost compounded GLP-1 with pharmacy quality transparency and a starting price around $100/mo.
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LegitScript-verified compounded GLP-1 via named pharmacies
From $149/mo
Get started →Framework vs NewSelf: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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