Edessa vs Amazon One Medical
An in-depth comparison of two leading GLP-1 Providers
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Edessa
Best for: cheap month-to-month compounded GLP-1 with tirzepatide and an oral tablet option
Visit Edessa →
Amazon One Medical
Best for: the most authoritative brand-name GLP-1 channel, with same-day delivery
Visit Amazon One Medical →Edessa and Amazon One Medical are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, Amazon One Medical starts lower at $149/mo versus $179/mo, and Amazon One Medical edges ahead overall (8.5 vs 7.3 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
Edessa
Plan table on myedessa.com/product-glp-1-injection.html, verified 2026-09-01: 1 month $179, 3 month $160/mo, 6 month $135/mo. The homepage's 'Start for just $135' is the six-month prepay rate, not the month-to-month price.
1 month $229, 3 month $209/mo, 6 month $199/mo (myedessa.com/product-glp-1-tablet.html). 'Compounded semaglutide medication' is what the page says you receive.
1 month $239, 3 month $219/mo, 6 month $209/mo (myedessa.com/product-glp-1-tirzepatide.html).
Amazon One Medical
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What’s included
Edessa
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Amazon One Medical
What the monthly price covers
Medication
Billed separately
Provider visits
Included
Shipping
Included
Lab work
Billed separately
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Edessa
7.3/10
Amazon One Medical
8.5/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | Edessa | Amazon One Medical |
|---|---|---|
| Starting Price | $179/mo | ✓$149/mo |
| Features | ✓8 features | 6 features |
| States Available | ✓51 | 50 |
| Compounded | ✓ Yes | — |
| Brand Name | — | ✓ Yes |
| FSA/HSA Accepted | ✓ Yes | — |
| FDA Warnings | None | None |
About Edessa
Edessa is a Las Vegas-based telehealth brand selling compounded semaglutide injections at $179/mo month-to-month (down to $135/mo on a six-month plan), a daily dissolvable semaglutide tablet from $229/mo and compounded tirzepatide from $239/mo. Care is delivered by OpenLoop Health clinicians and four named US compounding pharmacies, with medication, consult and expedited shipping in one cash-pay price and the same price at every dose.
Read our full Edessa review →About Amazon One Medical
Amazon One Medical is the unified Amazon GLP-1 channel — One Medical clinicians prescribe FDA-approved Wegovy, Zepbound, and Foundayo (no compounded products), and Amazon Pharmacy fulfills with same-day delivery across roughly 3,000 US cities plus pickup kiosks at select One Medical locations. No prior membership required; insurance and cash pay both accepted. Foundayo launched at $25/month with insurance and the Lilly Savings Card, or $149/month cash pay.
Read our full Amazon One Medical review →Pros & Cons
Edessa
What we like
- Month-to-month compounded semaglutide at $179 with no contract, dropping to $135/mo on the six-month plan
- Tirzepatide and a daily dissolvable tablet sit alongside the standard weekly injection
- Every product page prints the 1-, 3- and 6-month rate side by side and states 'Same price, every dose'
- Medication, physician review, ongoing check-ins and free expedited cold-chain shipping are in the one price
- Four named US pharmacy partners with addresses (RedRock, Health Warehouse, Precision Compounding, Triad Rx)
- Care delivered through the OpenLoop Health licensed provider network, listed in all 50 states and DC
- Cash-pay with no insurance required, and HSA/FSA eligible
Watch-outs
- The advertised '$135' is the six-month prepay rate; month-to-month is $179, and the FAQ still calls $135 a first-month price 'with no contract'
- The 'no questions asked' guarantee is not the policy: the Terms need proof of no weight loss after five months, minus 25% consult fees
- The Terms also say all sales are final and consult fees are never refundable
- The Terms contain no auto-renewal or cancellation section, so what happens at the end of a prepaid term is not published
- You pay before the clinician review — an OpenLoop clinician meets you after checkout to decide whether you qualify
- Homepage figures (100,000+ patients, 18% average weight loss, 93% kept it off) carry no cited source
- No published support hours, and support is email and phone only
- Compounded GLP-1s are not FDA-approved
Amazon One Medical
What we like
- As low as $1/day ($25/month) for brand-name Foundayo with insurance and the auto-applied Lilly coupon
- Same-day delivery in nearly 3,000 US cities at launch, expanding to 4,500 by end of 2026
- In-office pharmacist kiosks at select One Medical clinics let you walk out with Foundayo in hand
- Cash-pay $5/day ($149/month) is competitive for the same FDA-approved brand-name product
- Real-time availability, transparent pricing, and automatic manufacturer coupon at checkout
- Delivering GLP-1 medications since 2021 — track record on cold-chain logistics
Watch-outs
- Headline $25/month needs both insurance and the Lilly Savings Card — uninsured pay $149/month
- Same-day delivery is geographically gated; outside major cities it drops to next-day or slower
- Pricing is set by manufacturer savings programs and can change at any time
- No compounded options — brand-name only (Foundayo, Wegovy, Zepbound)
- Wegovy/Zepbound pricing isn't shown upfront — depends on insurance at the prescribing visit
- Copays and deductibles still apply to the clinical visit
Our Verdict
Amazon One Medical edges out Edessa with a higher overall score of 8.5/10 and is particularly strong for the most authoritative brand-name GLP-1 channel, with same-day delivery. Edessa remains a solid alternative, especially if you're looking for cheap month-to-month compounded GLP-1 with tirzepatide and an oral tablet option.
Choose Edessa if…
You want cheap month-to-month compounded GLP-1 with tirzepatide and an oral tablet option and a starting price around $179/mo.
Choose Amazon One Medical if…
You want the most authoritative brand-name GLP-1 channel, with same-day delivery and a starting price around $149/mo.
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Fitness-brand compounded GLP-1 with hormone and performance programs
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Compounded or brand GLP-1 bundled with TRT and peptides for men
From $100/mo
Get started →Direct Meds
Listed for disclosure only — see its FDA warning and BBB complaints first
From $249/mo
Get started →Edessa vs Amazon One Medical: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.