Direct Meds vs SkinnyRx
In our scoring, SkinnyRx edges ahead overall (7.6 vs 6.4 out of 10), and SkinnyRx costs less for compounded semaglutide (about $1,773 a year less).
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Key differences
- Price
- SkinnyRx $149.25/mo vs Direct Meds $297/mo for compounded semaglutide (standing prices, no prepay or separate membership listed · about $1,773 a year less with SkinnyRx)
- Included
- Direct Meds: medication, clinician visits, shipping; SkinnyRx: medication, clinician visits, shipping
Direct Meds
Affiliate partnerAlso prices oral compounded tirzepatide
semaglutide
$297
Our score 6.4/10
SkinnyRx
Affiliate partnerBest for compounded semaglutide or tirzepatide with the consult and free overnight shipping in one price
semaglutide
$149.25
Our score 7.6/10
We may earn a commission if you sign up through these links. Partner status can affect which provider we feature; it never changes a score or a price.
Costs & coverage
Published prices with their terms attached. Yearly figures are modeled from the standing price and billing cadence. A check mark marks the better side, on like-for-like rows only.
Direct Meds
SkinnyRx
Price
Semaglutide / month
$297/mo
Better on this row: $149.25/mo
Semaglutide / year (modeled)
$3,564
Better on this row: $1,791
Tirzepatide / month
$399/mo
Better on this row: $224.25/mo
Tirzepatide / year (modeled)
$4,788
Better on this row: $2,691
Oral semaglutide / month
$249/mo
Better on this row: $199/mo
Oral semaglutide / year (modeled)
$2,988
Better on this row: $2,388
Oral tirzepatide / month
$299/mo
Not listed
Brand Wegovy / Ozempic / month
Not listed
$1,400/mo
Brand Zepbound / Mounjaro / month
Not listed
$1,400/mo
Coverage
Oral option listed
Yes
Yes
Brand-name access listed
Not listed
Wegovy / Ozempic, Zepbound / Mounjaro
Included in the price
Medication, clinician visits, shipping
Medication, clinician visits, shipping
Terms & safety
Price shown
Before intake
Plan quoted after intake; a price is published
Cancel anytime
No
Not disclosed
Minimum commitment
3-month prepay
Not disclosed
Refunds
Not disclosed
90-day money-back guarantee
Early-cancellation fee
Yes
Not disclosed
FDA warning letters
1 warning letter
1 warning letter
Provider facts checked
August 2026
August 2026
Every dose and plan: Direct Meds · SkinnyRx
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Which fits your priorities?
Only the points where these two differ, from the table above and each provider’s record.
Choose Direct Meds if…
- Lists oral compounded tirzepatide, which SkinnyRx doesn't price
- All-inclusive pricing covers medication, consultations, supplies, and 1–2 day temperature-controlled shipping
- LegitScript Certified
What to weigh up
- 1 FDA warning letter on record
- About $1,773 a year more than SkinnyRx for compounded semaglutide
- FDA warning letter (Sept 2025) for marketing compounded GLP-1s as equivalent to FDA-approved drugs
Choose SkinnyRx if…
- About $1,773 a year less than Direct Meds for compounded semaglutide at standing prices
- Lists brand-name Wegovy / Ozempic and brand-name Zepbound / Mounjaro, which Direct Meds doesn't price
- Licensed US clinicians on every prescription
What to weigh up
- 1 FDA warning letter on record
Explore the scoring factors
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Direct Meds
6.4/10
SkinnyRx
7.6/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
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Direct Meds vs SkinnyRx: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.