Direct Meds vs NewSelf
Our featured pick: Direct Meds (affiliate partner). In our scoring, Direct Meds scores 6.4 and NewSelf 8.2 out of 10.
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Key differences
- Price
- Direct Meds $297/mo no prepay listed; NewSelf $100/mo on a 3-month prepaid plan (compounded semaglutide · not like-for-like, so neither is marked cheaper)
- Coverage
- NewSelf 48 states + PR (Direct Meds doesn't publish a state list)
- Included
- Direct Meds: medication, clinician visits, shipping; NewSelf: medication, clinician visits, shipping
Direct Meds
Affiliate partner$297/mo compounded semaglutide, no prepay needed
semaglutide
$297
Our score 6.4/10
NewSelf
Best for lowest-cost compounded GLP-1 at one price for every dose, if a 3-month commitment works for you
semaglutide
$100
on a 3-month prepaid plan
Our score 8.2/10
We may earn a commission if you sign up through these links. Partner status can affect which provider we feature; it never changes a score or a price.
Costs & coverage
Published prices with their terms attached. Yearly figures are modeled from the standing price and billing cadence. A check mark marks the better side, on like-for-like rows only.
Direct Meds
NewSelf
Price
Semaglutide / month
$297/mo
$100/mo
on a 3-month prepaid plan
Semaglutide / year (modeled)
$3,564
$1,200
Tirzepatide / month
$399/mo
$144/mo
on a 3-month prepaid plan
Tirzepatide / year (modeled)
$4,788
$1,728
Oral semaglutide / month
$249/mo
Not listed
Oral tirzepatide / month
$299/mo
Not listed
Coverage
State availability
List not published
48 states + PR
Oral option listed
Yes
Not listed
Included in the price
Medication, clinician visits, shipping
Medication, clinician visits, shipping
Terms & safety
Price shown
Before intake
Before intake
Cancel anytime
No
No
Minimum commitment
3-month prepay
3-month plan for the listed price
Refunds
Not disclosed
No refunds after the doctor visit; full refund if the doctor declines; $99 fee if you cancel before the visit
Early-cancellation fee
Yes
Yes
FDA warning letters
1 warning letter
1 warning letter
Provider facts checked
August 2026
October 2026
Every dose and plan: Direct Meds · NewSelf
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Which fits your priorities?
Only the points where these two differ, from the table above and each provider’s record.
Choose Direct Meds if…
- Its $297/mo compounded semaglutide price needs no prepay; NewSelf's $100 needs a 3-month prepay
- Lists oral compounded semaglutide and oral compounded tirzepatide, which NewSelf doesn't price
- All-inclusive pricing covers medication, consultations, supplies, and 1–2 day temperature-controlled shipping
What to weigh up
- 1 FDA warning letter on record
- No published state list; confirm yours at signup
- FDA warning letter (Sept 2025) for marketing compounded GLP-1s as equivalent to FDA-approved drugs
Choose NewSelf if…
- Publishes its full state list (48 states + PR)
- Same price at every dose, so your bill doesn't rise as you titrate up
- No membership fee; the visit, medication and shipping are bundled
What to weigh up
- 1 FDA warning letter on record
- Its $100/mo compounded semaglutide price needs a 3-month prepaid plan
Explore the scoring factors
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Direct Meds
6.4/10
NewSelf
8.2/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Ready to start? Vetted GLP-1 providers
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Ivim Health
Compounded GLP-1 with weekly provider check-ins and health coaches, under a required monthly membership
Read full review →From $65/mo + membership
Get started →From $247/mo
Get started →From $139/mo
Get started →Direct Meds vs NewSelf: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
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