Direct Meds vs NewSelf
An in-depth comparison of two leading GLP-1 Providers
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Direct Meds
Best for: listed for transparent disclosure — see FDA warning and BBB complaint pattern before considering
Visit Direct Meds →
NewSelf
Best for: lowest-cost compounded GLP-1 with pharmacy quality transparency
Visit NewSelf →Direct Meds and NewSelf are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, NewSelf starts lower at $100/mo versus $249/mo, and Direct Meds is the option we'd start with for most patients. Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
Direct Meds
Portal shows 'As low as $249.00'; inline JSON minMonthly $237 at some dosages; 90-day supply flow (SEMAGLUTIDE_SUB_90_MONTHLY). Unchanged vs our data.
'As low as $297.00 or $9.58 per day'; flow code INT_MTH_084D_3PK (84-day 3-pack billed monthly). Unchanged vs our data.
CHANGED: was $399 in providers.json, now 'As low as $299.00 or $9.65 per day' (TIRZEPATIDE_SUB_90_MONTHLY_3MG_DAY).
'As low as $399.00 or $12.87 per day'; the '$9.58 per day' string on the public /products/tirzepatide marketing page is a copy error (matches sema math). Unchanged vs our data.
NewSelf
All dosages same price
All dosages same price
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What’s included
Direct Meds
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
NewSelf
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Direct Meds
6.4/10
NewSelf
8.3/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | Direct Meds | NewSelf |
|---|---|---|
| Starting Price | $249/mo | ✓$100/mo |
| Features | 5 features | ✓6 features |
| States Available | Not disclosed | 49 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | 1 warning | ✓None |
About Direct Meds
Direct Meds is a Utah-based telehealth provider offering compounded semaglutide and tirzepatide in injection and sublingual formats. Listed here with full disclosure of a September 2025 FDA warning letter for misleading marketing, plus a documented pattern of customers reporting unexpected 3-month commitment charges — see warnings and cons before considering.
Read our full Direct Meds review →About NewSelf
NewSelf offers compounded semaglutide+ (with B12/Glycine, from $99.97/mo) and compounded tirzepatide+ (with B6/Glycine, from $144.49/mo). LegitScript certified. Available in 48 states + Puerto Rico. Uses 503A licensed pharmacies with third-party testing.
Read our full NewSelf review →Pros & Cons
Direct Meds
What we like
- Semaglutide and tirzepatide available in both injection and sublingual formats
- All-inclusive pricing covers medication, consultations, supplies, and 1–2 day temperature-controlled shipping
- LegitScript Certified
- Named 503A pharmacy partners: CraftedRx (MO) and ChemistryRx (PA)
Watch-outs
- FDA warning letter (Sept 2025) for marketing compounded GLP-1s as equivalent to FDA-approved drugs
- BBB rating 1.12/5 across 226 reviews citing a hidden 3-month commitment (charges of $940+ when buyers expected 1 month)
- Wide rating gap: Trustpilot 4.6/5 vs BBB 1.12/5 — points to review-solicitation bias or unresolved complaints
- Not available in Mississippi, Louisiana, or California
- Compounded only — no FDA-approved Ozempic, Wegovy, Zepbound, or Mounjaro
- Auto-renews until you cancel by email; complaints report long hold times and retention friction
NewSelf
What we like
- Semaglutide+ from $99.97/mo — among the lowest prices in the dataset
- All dosages at the same price — no price escalation as dose increases
- LegitScript certified with 503A licensed pharmacies
- Third-party potency, sterility, and endotoxicity testing
- 48 states + Puerto Rico coverage
- B12/B6 + Glycine enhanced formulations
- No membership fees
Watch-outs
- Not available in Mississippi and Louisiana
- Compounded only — no brand-name options
- Site also promotes AI health optimization and longevity (broader platform)
Our Verdict
Direct Meds is our recommended choice here, particularly for listed for transparent disclosure — see FDA warning and BBB complaint pattern before considering. NewSelf is a solid alternative, especially if you want lowest-cost compounded GLP-1 with pharmacy quality transparency — compare the six-dimension breakdown and pricing below to weigh them for your situation.
Choose Direct Meds if…
You want listed for transparent disclosure — see FDA warning and BBB complaint pattern before considering and a starting price around $249/mo.
Choose NewSelf if…
You want lowest-cost compounded GLP-1 with pharmacy quality transparency and a starting price around $100/mo.
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RxSpan MD
Shoppers wanting physician-led, pharmacy-transparent compounded GLP-1 with brand-name options
From $179/mo
Get started →Strut Health
Oral-lozenge compounded GLP-1 access
From $99/mo
Get started →Yucca Health
Mainstream telehealth GLP-1 access
From $146/mo
Get started →Direct Meds vs NewSelf: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
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