Collective vs Defy Medical
An in-depth comparison of two leading GLP-1 Providers
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Collective
Best for: the lowest flat medication price if you can absorb an annual membership fee
Visit Collective →
Defy Medical
Best for: GLP-1 in injection, ODT, or drop forms with thorough lab workups
Visit Defy Medical →Collective and Defy Medical are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, Collective starts at $59/mo, and Collective edges ahead overall (8.3 vs 7.0 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
Collective
Verbatim: 'Compounded Semaglutide: $59/month. Same price, every dose. Cancel anytime.' ⛔ EXCLUDES the required membership — the site states 'What does it cost? $59/month + $199 annual membership.' First-year total is $907 ($75.58/mo equivalent).
Verbatim: 'Compounded Tirzepatide: $69/month. Same price, any dose.' ⛔ EXCLUDES the required membership — 'The cost is $69/month + $199 annual membership.' First-year total is $1,027 ($85.58/mo equivalent).
Verbatim: 'Requires Collective membership: 21 day free trial, then a low annual $199 membership fee. No recurring monthly membership charges.' Charged yearly, not monthly. Terms of Use: 'all membership fees are non-refundable, and partial-period refunds are not provided.'
Defy Medical
Pricing not publicly listed.
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What’s included
Collective
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Defy Medical
Inclusions not disclosed.
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Collective
8.3/10
Defy Medical
7.0/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | Collective | Defy Medical |
|---|---|---|
| Starting Price | $59/mo | — |
| Features | 3 features | ✓8 features |
| States Available | Not disclosed | Not disclosed |
| Compounded | ✓ Yes | — |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About Collective
Collective (collective.org) is a membership-based telehealth platform from the founder of Thrive Market, selling compounded semaglutide and tirzepatide at a flat price on every dose. Medication is billed separately from a required annual membership, and the program bundles unlimited clinician messaging, dietitian access and express cold shipping.
Read our full Collective review →About Defy Medical
Defy Medical is a long-running telehealth clinic, best known for hormone replacement, that also prescribes GLP-1 medications for weight loss. It offers semaglutide and tirzepatide as weekly injections plus oral disintegrating tablets (ODT) and liquid drops, and liraglutide as a daily injection. The drops and ODT forms help patients avoid self-injecting or get treatment where injectable shipping is restricted. Care includes in-depth consults and comprehensive blood testing, with mobile phlebotomy. Medical director is Dr. Justin Saya. GLP-1 pricing and state coverage are not published online.
Read our full Defy Medical review →Pros & Cons
Collective
What we like
- The lowest published compounded GLP-1 medication prices we track — $59/month semaglutide and $69/month tirzepatide
- Flat pricing at every dose, so titrating up does not raise the bill
- Unlimited clinician messaging and registered-dietitian access are included rather than upsold
- 21-day free trial on the membership before the annual fee is charged
Watch-outs
- The advertised $59 and $69 exclude a mandatory $199 annual membership — the real first-year cost is $907 and $1,027
- Membership fees are non-refundable and no partial-period refunds are given
- Compounding pharmacies are described only as 'independent, third-party licensed pharmacies' and are never named
- State availability is not published on the marketing site
Defy Medical
What we like
- Multiple GLP-1 options: semaglutide, tirzepatide, liraglutide
- Offers injection, ODT, and oral drop delivery forms
- Comprehensive blood testing and named medical director
- Established clinic with strong Trustpilot review volume
Watch-outs
- GLP-1 pricing not published on the website
- States served and shipping limits not disclosed
- Compounded versus brand status not stated online
- Lab-heavy, consult-first model may cost more upfront
Our Verdict
Collective edges out Defy Medical with a higher overall score of 8.3/10 and is particularly strong for the lowest flat medication price if you can absorb an annual membership fee. Defy Medical remains a solid alternative, especially if you're looking for GLP-1 in injection, ODT, or drop forms with thorough lab workups.
Choose Collective if…
You want the lowest flat medication price if you can absorb an annual membership fee and a starting price around $59/mo.
Choose Defy Medical if…
You want GLP-1 in injection, ODT, or drop forms with thorough lab workups.
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Enhance MD
Lab-monitored compounded GLP-1 with mandatory video visit
From $112/mo
Get started →MEDVi
Switching between compounded and brand-name GLP-1 through one provider
From $99/mo
Get started →RxSpan MD
Physician-led, pharmacy-transparent compounded GLP-1 with brand-name options
From $179/mo
Get started →Collective vs Defy Medical: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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