Clume Health vs Amazon One Medical
An in-depth comparison of two leading GLP-1 Providers
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Clume Health
Best for: readers who want a separately priced microdose track and named dispensing pharmacies
Visit Clume Health →
Amazon One Medical
Best for: the most authoritative brand-name GLP-1 channel, with same-day delivery
Visit Amazon One Medical →Clume Health and Amazon One Medical are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, Amazon One Medical starts lower at $149/mo versus $219/mo, and Amazon One Medical edges ahead overall (8.5 vs 7.1 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
Clume Health
The $186/mo figure is a 52-week prepaid term, not an ongoing monthly rate.
The $186/mo figure is a 52-week prepaid term, not an ongoing monthly rate.
The $200/mo figure requires a 12-week prepaid term.
The $200/mo figure requires a 12-week prepaid term.
Amazon One Medical
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What’s included
Clume Health
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Amazon One Medical
What the monthly price covers
Medication
Billed separately
Provider visits
Included
Shipping
Included
Lab work
Billed separately
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Clume Health
7.1/10
Amazon One Medical
8.5/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | Clume Health | Amazon One Medical |
|---|---|---|
| Starting Price | $219/mo | ✓$149/mo |
| Features | 5 features | ✓6 features |
| States Available | Not disclosed | 50 |
| Compounded | ✓ Yes | — |
| Brand Name | — | ✓ Yes |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About Clume Health
Clume Health sells compounded semaglutide and tirzepatide in oral and injectable form across three tiers: a full-dose Signature program from $259/mo, a Microdose/Maintain program from $219/mo, and an NAD+ and sermorelin longevity track. Its terms name four dispensing pharmacies outright, which most compounded sellers will not do. Clinical care runs through OpenLoop, and cheaper per-month rates are available only by prepaying a 12- or 52-week term.
Read our full Clume Health review →About Amazon One Medical
Amazon One Medical is the unified Amazon GLP-1 channel — One Medical clinicians prescribe FDA-approved Wegovy, Zepbound, and Foundayo (no compounded products), and Amazon Pharmacy fulfills with same-day delivery across roughly 3,000 US cities plus pickup kiosks at select One Medical locations. No prior membership required; insurance and cash pay both accepted. Foundayo launched at $25/month with insurance and the Lilly Savings Card, or $149/month cash pay.
Read our full Amazon One Medical review →Pros & Cons
Clume Health
What we like
- Names four dispensing pharmacies in its terms, a level of disclosure most compounded sellers avoid.
- Offers both full-dose and microdose tracks, so maintenance has its own priced program.
- Sells semaglutide and tirzepatide in oral as well as injectable form.
- Lists what the monthly price covers, including consultation, medication and at-home delivery.
- Cancellation is allowed at any time by email or through the patient portal.
Watch-outs
- The homepage advertises "starting at *$199/month" and "*$159/month", but no program is priced at either figure.
- Those asterisks lead to no footnote anywhere on the page.
- The cheapest advertised rates require prepaying a full term — $186/mo means a 52-week commitment.
- Canceling needs 72 hours' notice before the next billing date or you are charged for that cycle.
- No refund is issued for the month in which you cancel, or for any prior month.
- Personalized options appear only after you accept OpenLoop's telehealth consent.
- No LegitScript seal or other verified trust badge appears anywhere on the site.
- Support is email only; no phone number or published hours.
Amazon One Medical
What we like
- As low as $1/day ($25/month) for brand-name Foundayo with insurance and the auto-applied Lilly coupon
- Same-day delivery in nearly 3,000 US cities at launch, expanding to 4,500 by end of 2026
- In-office pharmacist kiosks at select One Medical clinics let you walk out with Foundayo in hand
- Cash-pay $5/day ($149/month) is competitive for the same FDA-approved brand-name product
- Real-time availability, transparent pricing, and automatic manufacturer coupon at checkout
- Delivering GLP-1 medications since 2021 — track record on cold-chain logistics
Watch-outs
- Headline $25/month needs both insurance and the Lilly Savings Card — uninsured pay $149/month
- Same-day delivery is geographically gated; outside major cities it drops to next-day or slower
- Pricing is set by manufacturer savings programs and can change at any time
- No compounded options — brand-name only (Foundayo, Wegovy, Zepbound)
- Wegovy/Zepbound pricing isn't shown upfront — depends on insurance at the prescribing visit
- Copays and deductibles still apply to the clinical visit
Our Verdict
Amazon One Medical edges out Clume Health with a higher overall score of 8.5/10 and is particularly strong for the most authoritative brand-name GLP-1 channel, with same-day delivery. Clume Health remains a solid alternative, especially if you're looking for readers who want a separately priced microdose track and named dispensing pharmacies.
Choose Clume Health if…
You want readers who want a separately priced microdose track and named dispensing pharmacies and a starting price around $219/mo.
Choose Amazon One Medical if…
You want the most authoritative brand-name GLP-1 channel, with same-day delivery and a starting price around $149/mo.
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Gala
Compounded GLP-1/GIP combo on a yearly plan with free shipping
From $149/mo
Get started →TMates
Nationwide compounded GLP-1 availability including Puerto Rico
From $249/mo
Get started →Trimi Health
Budget-conscious shoppers
From $99/mo
Get started →Clume Health vs Amazon One Medical: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.