Cielo vs Amazon One Medical
An in-depth comparison of two leading GLP-1 Providers
WeightLossRankings.org is reader-supported. When you buy through links on our site, we may earn an affiliate commission. Learn more
Cielo
Best for flat-rate compounded GLP-1 at the lowest 3-month bundle pricesStarting at $115/mo
Amazon One Medical
Best for the most authoritative branded GLP-1 channel with same-day delivery and integrated manufacturer savingsStarting at $25/mo
Side-by-Side Comparison
| Feature | Cielo | Amazon One Medical |
|---|---|---|
| Overall Score | 7.5/10 | ✓8.7/10 |
| Starting Price | $115/mo | ✓$25/mo |
| Editorial Rating | 3.8 ★ /5 | ✓4.4 ★ /5 |
| Features | ✓8 features | 6 features |
| States Available | 0 | ✓50 |
| Compounded | ✓ Yes | — |
| Brand Name | — | ✓ Yes |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
Pros & Cons
Cielo
Pros
- ✓Among the lowest 3-month bundle prices in compounded GLP-1 ($115/mo semaglutide)
- ✓Single flat price across all doses simplifies titration planning
- ✓Corporate address (St. Petersburg, FL) and customer-service phone published
Cons
- ✗No LegitScript, NABP .pharmacy, or HIPAA badge on the home page
- ✗Pharmacy partner not named (only 'regulated FDA pharmacy partners')
- ✗State coverage list not published — can't verify all-50-state availability
- ✗Clinical care runs through MD Integrations, a shared third-party network used by many brands
- ✗No brand-name Wegovy or Zepbound option
- ✗Donation page shows 0% next to a 10%-pledge claim — an apparent discrepancy
Amazon One Medical
Pros
- ✓As low as $1/day ($25/month) for brand-name Foundayo with insurance and the auto-applied Lilly coupon
- ✓Same-day delivery in nearly 3,000 US cities at launch, expanding to 4,500 by end of 2026
- ✓In-office pharmacist kiosks at select One Medical clinics let you walk out with Foundayo in hand
- ✓Cash-pay $5/day ($149/month) is competitive for the same FDA-approved brand-name product
- ✓Real-time availability, transparent pricing, and automatic manufacturer coupon at checkout
- ✓Delivering GLP-1 medications since 2021 — track record on cold-chain logistics
Cons
- ✗Headline $25/month needs both insurance and the Lilly Savings Card — uninsured pay $149/month
- ✗Same-day delivery is geographically gated; outside major cities it drops to next-day or slower
- ✗Pricing is set by manufacturer savings programs and can change at any time
- ✗No compounded options — brand-name only (Foundayo, Wegovy, Zepbound)
- ✗Wegovy/Zepbound pricing isn't shown upfront — depends on insurance at the prescribing visit
- ✗Copays and deductibles still apply to the clinical visit
Our Verdict
Amazon One Medical edges out Cielo with a higher overall score of 8.7/10 and is particularly strong for the most authoritative branded GLP-1 channel with same-day delivery and integrated manufacturer savings. Cielo remains a solid alternative, especially if you're looking for flat-rate compounded GLP-1 at the lowest 3-month bundle prices.
Glossary references
Key terms in this article, linked to their canonical definitions.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
Related comparisons
Continue exploring Cielo and Amazon One Medical head-to-heads in the same category.
- Cielo vs CoreAge Rx
- Cielo vs TrimRx
- Cielo vs NovoCare Pharmacy
- Amazon One Medical vs Vytora Health
- Amazon One Medical vs Enhance MD
- Amazon One Medical vs Noom Med
Or see the full category ranking.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.