Amazon One Medical vs Zappy Health
An in-depth comparison of two leading GLP-1 Providers
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Amazon One Medical
Best for: the most authoritative branded GLP-1 channel with same-day delivery and integrated manufacturer savings
Visit Amazon One Medical →
Zappy Health
Best for: people wanting both compounded and brand-name GLP-1 with flat pricing that doesn't rise with dose
Visit Zappy Health →Amazon One Medical and Zappy Health are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, Amazon One Medical starts lower at $149/mo versus $159/mo, and Amazon One Medical edges ahead overall (8.5 vs 6.9 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
Amazon One Medical
Zappy Health
From $159/mo (9-mo); $199 (3-mo); $249 month-to-month; flat across doses
From $299/mo (9-mo); $329 (3-mo); $359 month-to-month; flat across doses
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What’s included
Amazon One Medical
What the monthly price covers
Medication
Billed separately
Provider visits
Included
Shipping
Included
Lab work
Billed separately
Coaching
Not disclosed
Zappy Health
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Amazon One Medical
8.5/10
Zappy Health
6.9/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | Amazon One Medical | Zappy Health |
|---|---|---|
| Starting Price | ✓$149/mo | $159/mo |
| Features | 6 features | ✓8 features |
| States Available | ✓50 | 42 |
| Compounded | — | — |
| Brand Name | ✓ Yes | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About Amazon One Medical
Amazon One Medical is the unified Amazon GLP-1 channel — One Medical clinicians prescribe FDA-approved Wegovy, Zepbound, and Foundayo (no compounded products), and Amazon Pharmacy fulfills with same-day delivery across roughly 3,000 US cities plus pickup kiosks at select One Medical locations. No prior membership required; insurance and cash pay both accepted. Foundayo launched at $25/month with insurance and the Lilly Savings Card, or $149/month cash pay.
Read our full Amazon One Medical review →About Zappy Health
Zappy Health is a telehealth weight-loss platform offering both compounded and brand-name GLP-1: compounded semaglutide from $159/month and tirzepatide from $299/month, plus brand Wegovy and Zepbound. Pricing is flat — it doesn't rise with your dose — and longer subscriptions cost less. You complete an online visit and a licensed clinician prescribes if appropriate. Zappy operates in about 42 states (not HI, AL, AR, CA, KS, MI, MN or MS). Note that some third-party reports raise pharmacy-sourcing concerns.
Read our full Zappy Health review →Pros & Cons
Amazon One Medical
What we like
- As low as $1/day ($25/month) for brand-name Foundayo with insurance and the auto-applied Lilly coupon
- Same-day delivery in nearly 3,000 US cities at launch, expanding to 4,500 by end of 2026
- In-office pharmacist kiosks at select One Medical clinics let you walk out with Foundayo in hand
- Cash-pay $5/day ($149/month) is competitive for the same FDA-approved brand-name product
- Real-time availability, transparent pricing, and automatic manufacturer coupon at checkout
- Delivering GLP-1 medications since 2021 — track record on cold-chain logistics
Watch-outs
- Headline $25/month needs both insurance and the Lilly Savings Card — uninsured pay $149/month
- Same-day delivery is geographically gated; outside major cities it drops to next-day or slower
- Pricing is set by manufacturer savings programs and can change at any time
- No compounded options — brand-name only (Foundayo, Wegovy, Zepbound)
- Wegovy/Zepbound pricing isn't shown upfront — depends on insurance at the prescribing visit
- Copays and deductibles still apply to the clinical visit
Zappy Health
What we like
- Both compounded GLP-1 and brand-name Wegovy/Zepbound available
- Flat pricing that doesn't increase as your dose goes up
- Cheaper on longer subscriptions — compounded semaglutide from $159/month
- Online visit with a licensed clinician; no insurance required
Watch-outs
- Third-party reports of an order arriving with an unlicensed-pharmacy label
- Not available in 8 states (HI, AL, AR, CA, KS, MI, MN, MS)
- Operating legal entity isn't clearly disclosed on the site
- Lowest prices require a 9-month commitment
Our Verdict
Amazon One Medical edges out Zappy Health with a higher overall score of 8.5/10 and is particularly strong for the most authoritative branded GLP-1 channel with same-day delivery and integrated manufacturer savings. Zappy Health remains a solid alternative, especially if you're looking for people wanting both compounded and brand-name GLP-1 with flat pricing that doesn't rise with dose.
Choose Amazon One Medical if…
You want the most authoritative branded GLP-1 channel with same-day delivery and integrated manufacturer savings and a starting price around $149/mo.
Choose Zappy Health if…
You want people wanting both compounded and brand-name GLP-1 with flat pricing that doesn't rise with dose and a starting price around $159/mo.
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Gala
Compounded GLP-1/GIP combo therapy on a yearly subscription with free shipping nationwide
From $129/mo
Get started →TMates
Nationwide compounded GLP-1 availability including Puerto Rico
From $249/mo
Get started →Found
Mainstream telehealth GLP-1 access
From $99/mo
Get started →Amazon One Medical vs Zappy Health: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.