Amazon One Medical vs Trellis Vitality
An in-depth comparison of two leading GLP-1 Providers
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Amazon One Medical
Best for: the most authoritative brand-name GLP-1 channel, with same-day delivery
Visit Amazon One Medical →
Trellis Vitality
Best for: body-composition tracking and flat per-dose pricing without a membership fee
Visit Trellis Vitality →Amazon One Medical and Trellis Vitality are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, Amazon One Medical starts lower at $149/mo versus $150/mo, and Amazon One Medical edges ahead overall (8.5 vs 7.5 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
Amazon One Medical
Trellis Vitality
Per-month rate falls on longer plans: $150 monthly, $140 on 3 months, $133 on 6 months. All dosages cost the same.
Per-month rate falls on longer plans: $199 monthly, $189 on 3 months, $179 on 6 months. All dosages cost the same.
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What’s included
Amazon One Medical
What the monthly price covers
Medication
Billed separately
Provider visits
Included
Shipping
Included
Lab work
Billed separately
Coaching
Not disclosed
Trellis Vitality
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Amazon One Medical
8.5/10
Trellis Vitality
7.5/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | Amazon One Medical | Trellis Vitality |
|---|---|---|
| Starting Price | ✓$149/mo | $150/mo |
| Features | 6 features | ✓7 features |
| States Available | 50 | 50 |
| Compounded | — | ✓ Yes |
| Brand Name | ✓ Yes | — |
| FSA/HSA Accepted | — | ✓ Yes |
| FDA Warnings | None | None |
About Amazon One Medical
Amazon One Medical is the unified Amazon GLP-1 channel — One Medical clinicians prescribe FDA-approved Wegovy, Zepbound, and Foundayo (no compounded products), and Amazon Pharmacy fulfills with same-day delivery across roughly 3,000 US cities plus pickup kiosks at select One Medical locations. No prior membership required; insurance and cash pay both accepted. Foundayo launched at $25/month with insurance and the Lilly Savings Card, or $149/month cash pay.
Read our full Amazon One Medical review →About Trellis Vitality
Trellis Vitality is an online longevity clinic that frames weight loss around body composition rather than scale weight. Compounded semaglutide starts at $150 a month and tirzepatide at $199, with every dose priced the same and no membership or consult fee layered on top. The programme pairs GLP-1s with at-home biomarker panels, a 90-day re-test, and muscle-preserving options such as tesamorelin and glycine formulations. Trellis is a care-coordination company; prescribing is done by the Arora Health provider network and dispensing by Houston pharmacy VialsRX.
Read our full Trellis Vitality review →Pros & Cons
Amazon One Medical
What we like
- As low as $1/day ($25/month) for brand-name Foundayo with insurance and the auto-applied Lilly coupon
- Same-day delivery in nearly 3,000 US cities at launch, expanding to 4,500 by end of 2026
- In-office pharmacist kiosks at select One Medical clinics let you walk out with Foundayo in hand
- Cash-pay $5/day ($149/month) is competitive for the same FDA-approved brand-name product
- Real-time availability, transparent pricing, and automatic manufacturer coupon at checkout
- Delivering GLP-1 medications since 2021 — track record on cold-chain logistics
Watch-outs
- Headline $25/month needs both insurance and the Lilly Savings Card — uninsured pay $149/month
- Same-day delivery is geographically gated; outside major cities it drops to next-day or slower
- Pricing is set by manufacturer savings programs and can change at any time
- No compounded options — brand-name only (Foundayo, Wegovy, Zepbound)
- Wegovy/Zepbound pricing isn't shown upfront — depends on insurance at the prescribing visit
- Copays and deductibles still apply to the clinical visit
Trellis Vitality
What we like
- Names both its pharmacy (VialsRX, Houston TX) and its prescribing network, with a street address and phone number for the pharmacy.
- All dosages cost the same, and there is no membership fee or consult charge on top of the monthly price.
- Frames the programme around body composition, with at-home biomarker panels and a 90-day re-test rather than scale weight alone.
- Will review labs from an existing compounded programme and recommend protocol adjustments free of charge.
Watch-outs
- Headline stats (92% biomarker improvement, $4,000 average annual saving, 3.4 weeks saved) are unsourced and cannot be checked.
- The "4.7 / 5 · 5,000+ current patients" rating names no review platform, so it cannot be verified against a public record.
- Prescribing runs through the Arora Health network, which several unrelated telehealth brands also use, so the clinical layer is not exclusive.
- Refund eligibility is decided per order rather than by a stated policy, so outcomes are discretionary.
Our Verdict
Amazon One Medical edges out Trellis Vitality with a higher overall score of 8.5/10 and is particularly strong for the most authoritative brand-name GLP-1 channel, with same-day delivery. Trellis Vitality remains a solid alternative, especially if you're looking for body-composition tracking and flat per-dose pricing without a membership fee.
Choose Amazon One Medical if…
You want the most authoritative brand-name GLP-1 channel, with same-day delivery and a starting price around $149/mo.
Choose Trellis Vitality if…
You want body-composition tracking and flat per-dose pricing without a membership fee and a starting price around $150/mo.
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Maximus
Men seeking compounded GLP-1 alongside testosterone optimization
From $199.99/mo
Get started →Sesame Care
Brand-name GLP-1s at cash prices, no compounding
From $25/mo
Get started →MEDVi
Switching between compounded and brand-name GLP-1 through one provider
From $99/mo
Get started →Amazon One Medical vs Trellis Vitality: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.