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Amazon One Medical vs Cost Plus Drugs
An in-depth comparison of two leading GLP-1 Providers
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8.7
Amazon One Medical
Best for the most authoritative branded GLP-1 channel with same-day delivery and integrated manufacturer savings★★★★☆4.4
Starting at $25/mo
FoundayoBrandSame-Day DeliveryAll 50 States
Visit Amazon One Medical →8.5
Cost Plus Drugs
Best for the cheapest transparent-pricing brand-name Ozempic channel★★★★☆4.3
Starting at $279/mo
OzempicBrandTransparent PricingAll 50 States
Visit Cost Plus Drugs →Side-by-Side Comparison
| Feature | Amazon One Medical | Cost Plus Drugs |
|---|---|---|
| Overall Score | ✓8.7/10 | 8.5/10 |
| Starting Price | ✓$25/mo | $279/mo |
| Editorial Rating | ✓4.4 ★ /5 | 4.3 ★ /5 |
| Features | ✓6 features | 5 features |
| States Available | 50 | 50 |
| Compounded | — | — |
| Brand Name | ✓ Yes | ✓ Yes |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
Pros & Cons
Amazon One Medical
Pros
- ✓$1/day ($25/month) with insurance and the automatically-applied Lilly manufacturer-sponsored coupon — the cheapest brand-name Foundayo channel we've seen
- ✓Same-day delivery in nearly 3,000 US cities and towns at launch, expanding to 4,500 by year-end 2026 — most aggressive delivery footprint of any GLP-1 distribution channel
- ✓In-office, licensed-pharmacist-supported kiosks at select One Medical locations let patients walk out of an appointment with their Foundayo in hand — bypasses pharmacy lines entirely
- ✓Cash-pay $5/day ($149/month) is competitive with Ro and GoodRx for the same FDA-approved brand-name product
- ✓Real-time medication availability + transparent pricing + automatic manufacturer coupon application before checkout
- ✓Has been delivering GLP-1 medications since 2021 — operational track record on cold-chain biologic logistics
- ✓24/7 access to licensed pharmacists for clinical questions
Cons
- ✗Headline $25/month Foundayo price requires both insurance coverage AND the Lilly Savings Card — uninsured patients pay the $149/month cash price
- ✗Same-day delivery is geographically gated — outside the ~3,000 cities, delivery falls back to next-day, two-day, or three-day depending on remoteness
- ✗Pricing is set by manufacturer (Lilly, Novo Nordisk) savings programs and can change at any time
- ✗Does not offer compounded semaglutide or tirzepatide — brand-name only (Foundayo, Wegovy, Zepbound)
- ✗Wegovy / Zepbound pricing is not publicly disclosed on the Amazon One Medical landing page — it depends on insurance coverage at the prescribing visit. Plan to review final pricing at checkout before committing
- ✗One Medical clinical visits accept insurance, but copays/deductibles still apply for the Scheduled Visit; cash-pay visit pricing is also disclosed on enrollment
Cost Plus Drugs
Pros
- ✓Transparent pricing formula: wholesale acquisition cost + 15% markup + $5 pharmacy fee — publicly disclosed and the same for everyone (no insurance gatekeeping, no negotiated PBM rebate games)
- ✓~$279/month for branded Ozempic is meaningfully below retail pharmacy list prices for the same FDA-approved manufacturer product
- ✓Mark Cuban's PBM-disrupting platform has earned editorial credibility from Forbes Health, Wired, and KFF Health News for its pricing transparency
- ✓Ships to all 50 states; same FDA-approved Novo Nordisk Ozempic, no compounded reformulation
- ✓Partnered with 9amHealth for telehealth prescribing — you can get the prescription separately and pay Cost Plus pricing for fulfillment
Cons
- ✗Pharmacy fulfillment only — no telehealth intake, no prescribing clinicians on staff. You need a valid Ozempic prescription from an external clinician (PCP, endocrinologist, or telehealth provider) before Cost Plus can fill it
- ✗Ozempic is FDA-indicated for type 2 diabetes, not chronic weight management — your prescribing clinician's documentation matters for off-label weight-loss use
- ✗Wegovy availability through Cost Plus has historically been spotty — verify current Wegovy SKU status before assuming it ships
- ✗No compounded semaglutide or tirzepatide — brand-only model
- ✗No clinical follow-up included — fulfillment-only model means side-effect monitoring is on your prescribing clinician
Our Verdict
Winner: Amazon One MedicalScore: 8.7/10
Amazon One Medical edges out Cost Plus Drugs with a higher overall score of 8.7/10 and is particularly strong for the most authoritative branded GLP-1 channel with same-day delivery and integrated manufacturer savings. Cost Plus Drugs remains a solid alternative, especially if you're looking for the cheapest transparent-pricing brand-name Ozempic channel.
Glossary references
Key terms in this article, linked to their canonical definitions.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.