Amazon One Medical vs CaliberRx
An in-depth comparison of two leading GLP-1 Providers
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Amazon One Medical
Best for: the most authoritative brand-name GLP-1 channel, with same-day delivery
Visit Amazon One Medical →
CaliberRx
Best for: compounded GLP-1 from a compliance-thorough, fully online clinic
Visit CaliberRx →Amazon One Medical and CaliberRx are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, Amazon One Medical starts lower at $149/mo versus $199/mo, and Amazon One Medical edges ahead overall (8.5 vs 7.6 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
Amazon One Medical
CaliberRx
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What’s included
Amazon One Medical
What the monthly price covers
Medication
Billed separately
Provider visits
Included
Shipping
Included
Lab work
Billed separately
Coaching
Not disclosed
CaliberRx
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Amazon One Medical
8.5/10
CaliberRx
7.6/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | Amazon One Medical | CaliberRx |
|---|---|---|
| Starting Price | ✓$149/mo | $199/mo |
| Features | 6 features | ✓8 features |
| States Available | 50 | Not disclosed |
| Compounded | — | — |
| Brand Name | ✓ Yes | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About Amazon One Medical
Amazon One Medical is the unified Amazon GLP-1 channel — One Medical clinicians prescribe FDA-approved Wegovy, Zepbound, and Foundayo (no compounded products), and Amazon Pharmacy fulfills with same-day delivery across roughly 3,000 US cities plus pickup kiosks at select One Medical locations. No prior membership required; insurance and cash pay both accepted. Foundayo launched at $25/month with insurance and the Lilly Savings Card, or $149/month cash pay.
Read our full Amazon One Medical review →About CaliberRx
CaliberRx is a 100% online telehealth platform offering compounded GLP-1 weight-loss treatment — semaglutide and tirzepatide — prescribed by licensed clinicians after an online medical-history review. It runs a no-insurance, free discreet delivery model with 24/7 medical support, and publishes an unusually thorough legal and compliance suite (privacy practices, telehealth consent, state-privacy addendum, refund, billing, disclaimers). Pricing shows only after the intake quiz, compounded GLP-1s are not FDA-approved, the pharmacy is not named, and no LegitScript is displayed.
Read our full CaliberRx review →Pros & Cons
Amazon One Medical
What we like
- As low as $1/day ($25/month) for brand-name Foundayo with insurance and the auto-applied Lilly coupon
- Same-day delivery in nearly 3,000 US cities at launch, expanding to 4,500 by end of 2026
- In-office pharmacist kiosks at select One Medical clinics let you walk out with Foundayo in hand
- Cash-pay $5/day ($149/month) is competitive for the same FDA-approved brand-name product
- Real-time availability, transparent pricing, and automatic manufacturer coupon at checkout
- Delivering GLP-1 medications since 2021 — track record on cold-chain logistics
Watch-outs
- Headline $25/month needs both insurance and the Lilly Savings Card — uninsured pay $149/month
- Same-day delivery is geographically gated; outside major cities it drops to next-day or slower
- Pricing is set by manufacturer savings programs and can change at any time
- No compounded options — brand-name only (Foundayo, Wegovy, Zepbound)
- Wegovy/Zepbound pricing isn't shown upfront — depends on insurance at the prescribing visit
- Copays and deductibles still apply to the clinical visit
CaliberRx
What we like
- Compounded GLP-1 — semaglutide and tirzepatide — prescribed by licensed clinicians after an online medical-history review
- 100% online with free, discreet delivery and 24/7 medical support; no insurance required
- Thorough legal suite (privacy practices, telehealth consent, state-privacy addendum, refund, billing, program disclaimers)
- Personalized plan written by a licensed provider based on your individualized assessment
Watch-outs
- Pricing is not published — it is shown only after you complete the intake quiz
- Compounded GLP-1s are not FDA-approved, and the compounding pharmacy is not named
- State-availability list is not published
- No LegitScript certification displayed
Our Verdict
Amazon One Medical edges out CaliberRx with a higher overall score of 8.5/10 and is particularly strong for the most authoritative brand-name GLP-1 channel, with same-day delivery. CaliberRx remains a solid alternative, especially if you're looking for compounded GLP-1 from a compliance-thorough, fully online clinic.
Choose Amazon One Medical if…
You want the most authoritative brand-name GLP-1 channel, with same-day delivery and a starting price around $149/mo.
Choose CaliberRx if…
You want compounded GLP-1 from a compliance-thorough, fully online clinic and a starting price around $199/mo.
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Compounded semaglutide and tirzepatide at a flat monthly price
From $133/mo
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Fitness-brand compounded GLP-1 with hormone and performance programs
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Compounded or brand GLP-1 bundled with TRT and peptides for men
From $100/mo
Get started →Amazon One Medical vs CaliberRx: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.