1st Optimal vs Sprout Health
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: Patients wanting GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →
Sprout Health
Best for: LegitScript-verified compounded GLP-1 via named pharmacies
Visit Sprout Health →1st Optimal and Sprout Health are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, Sprout Health starts at $149/mo, and Sprout Health edges ahead overall (7.6 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Pricing not publicly listed.
Sprout Health
Homepage hero product card; no intro/promo qualifier found. A lower 'Compounded GLP-1s' category card on the same page says 'Starting $249' — internal site conflict; the per-drug hero card is the more specific figure.
Homepage hero product card. Checkout paths also reference a 'tirzepatide-tablet' SKU (oral form exists in funnel) but its price is quiz-gated = not published.
Near cash list price; unchanged.
Near cash list price; unchanged. Exact plan charges at checkout are quiz-gated (empty-cart template) = not published.
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What’s included
1st Optimal
Inclusions not disclosed.
Sprout Health
What the monthly price covers
Medication
Included
Provider visits
Not disclosed
Shipping
Not disclosed
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
Sprout Health
7.6/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | Sprout Health |
|---|---|---|
| Starting Price | — | $149/mo |
| Features | ✓8 features | 4 features |
| States Available | Not disclosed | 44 |
| Compounded | — | ✓ Yes |
| Brand Name | — | ✓ Yes |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About Sprout Health
Sprout Health Partners offers LegitScript-certified compounded semaglutide ($149/mo) and tirzepatide ($199/mo) via a quiz-first telehealth flow with licensed clinician review, shipping compounded medication from Foothills Pharmacy or Promise Pharmacy.
Read our full Sprout Health review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
Sprout Health
What we like
- LegitScript certification confirmed
- Both compounded semaglutide and tirzepatide available
- 44-state coverage via a pre-qualification quiz and licensed clinician review
- Two named 503A pharmacy partners: Foothills Pharmacy and Promise Pharmacy
Watch-outs
- Compounded only — no FDA-approved Ozempic, Wegovy, Zepbound, or Mounjaro
- Not available in Alabama, Arkansas, California, Louisiana, Mississippi, or North Dakota
- Pharmacy partner accreditation details (PCAB/ACHC) not independently verified
- Brand-name Wegovy ($1,799/mo) and Zepbound ($1,999/mo) are priced near cash list price — compounded is the only affordable path here
Our Verdict
Sprout Health edges out 1st Optimal with a higher overall score of 7.6/10 and is particularly strong for LegitScript-verified compounded GLP-1 via named pharmacies. 1st Optimal remains a solid alternative, especially if you're looking for Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose 1st Optimal if…
You want Patients wanting GLP-1 therapy within a lab-driven functional-medicine program.
Choose Sprout Health if…
You want LegitScript-verified compounded GLP-1 via named pharmacies and a starting price around $149/mo.
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Wellorithm
Compounded GLP-1 access with oral tablet options across 49 states
From $147/mo
Get started →SkinnyRx
Mainstream telehealth GLP-1 access
From $149.25/mo
Get started →Sunlight
Compounded GLP-1 with unlimited telehealth visits and free shipping
From $159/mo
Get started →1st Optimal vs Sprout Health: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.