1st Optimal vs One80Rx
An in-depth comparison of two leading GLP-1 Providers
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1st Optimal
Best for: GLP-1 therapy within a lab-driven functional-medicine program
Visit 1st Optimal →
One80Rx
Best for: low listed GLP-1 prices with flat dosing, including microdose and oral options
Visit One80Rx →1st Optimal and One80Rx are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, 1st Optimal starts lower at $99/mo versus $129/mo, and One80Rx edges ahead overall (6.8 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
1st Optimal
Care membership only — the GLP-1 medication is billed separately and is not priced.
One80Rx
Card reads "from $129/mo"; the site says plans are confirmed after provider review.
Card reads "from $229/mo"; the site says plans are confirmed after provider review.
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What’s included
1st Optimal
What the monthly price covers
Medication
Not disclosed
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Included
One80Rx
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
1st Optimal
6.7/10
One80Rx
6.8/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 1st Optimal | One80Rx |
|---|---|---|
| Starting Price | ✓$99/mo | $129/mo |
| Features | 8 features | 8 features |
| States Available | Not disclosed | Not disclosed |
| Compounded | — | ✓ Yes |
| Brand Name | ✓ Yes | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 1st Optimal
1st Optimal is a Michigan-based telehealth and functional-medicine platform offering GLP-1 weight loss medications, including semaglutide and tirzepatide, as once-weekly injections or daily oral tablets. Its model pairs prescription GLP-1 therapy with at-home lab testing, blood-work interpretation, unlimited coaching, and personalized protocols framed around long-term weight loss and longevity. Care is delivered virtually by credentialed providers, and treatments ship to the home with no long-term contracts. The site does not publish monthly pricing or a state list.
Read our full 1st Optimal review →About One80Rx
One80Rx is a Tampa-based telehealth platform selling compounded semaglutide and tirzepatide injections, plus a GLP-1 microdose program, an oral GLP-1 and a long list of peptides. Listed prices start at $129/mo for semaglutide and $229/mo for tirzepatide, and the site promises flat pricing with no dose-change surcharge. The catch is that every price is a "from" figure confirmed only after provider review, and the brand launched in mid-2026.
Read our full One80Rx review →Pros & Cons
1st Optimal
What we like
- Offers both semaglutide and tirzepatide with injectable and oral formats
- Functional-medicine approach with at-home labs and blood-work interpretation
- Unlimited coaching and ongoing support included
- No long-term contracts
- Board-certified doctors and nurse practitioners referenced
Watch-outs
- No public monthly pricing disclosed
- No published state availability list
- Compounded vs branded sourcing not clarified on site
- Pricing only revealed after quiz or consultation
One80Rx
What we like
- Low listed entry prices: semaglutide from $129/mo and tirzepatide from $229/mo
- Flat-rate pricing is promised with no consultation fee and no surcharge when your dose goes up
- $0 if a provider does not approve you, and the Terms refund you if no prescription is issued
- Four GLP-1 formats, including a lower-dose microdose program and a daily oral option
- Free 2–3 day shipping in temperature-controlled, unmarked packaging
- Support phone line and email published, with weekday hours of 9 AM to 5 PM
- Cancel from your patient portal by turning off auto-refill at least 48 hours before the next charge
Watch-outs
- Every price is a "from" figure confirmed only after provider review; the treatment pages show no price at all
- No price appears in the intake before it asks for your name, email, phone, birth date and shipping address
- Neither the compounding pharmacy nor the prescribing medical group is named anywhere on the site
- Shows a Trustpilot "4.8 / 5" rating, but no Trustpilot profile for the brand could be found
- Brand launched in mid-2026, yet the homepage claims "10k+" members beside a "1,743+ patients supported" counter
- Terms make you waive the right to fill your prescription at a pharmacy of your choice
- No refunds once medication is dispensed, and order cancellation is limited to 24 hours after purchase
- Compounded semaglutide and tirzepatide are not FDA-approved, as the site itself states
Our Verdict
One80Rx edges out 1st Optimal with a higher overall score of 6.8/10 and is particularly strong for low listed GLP-1 prices with flat dosing, including microdose and oral options. 1st Optimal remains a solid alternative, especially if you're looking for GLP-1 therapy within a lab-driven functional-medicine program.
Choose 1st Optimal if…
You want GLP-1 therapy within a lab-driven functional-medicine program and a starting price around $99/mo.
Choose One80Rx if…
You want low listed GLP-1 prices with flat dosing, including microdose and oral options and a starting price around $129/mo.
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Brightmeds
Compounded or brand GLP-1 bundled with TRT and peptides for men
From $100/mo
Get started →Direct Meds
Listed for disclosure only — see its FDA warning and BBB complaints first
From $249/mo
Get started →Maximus
Men seeking compounded GLP-1 alongside testosterone optimization
From $199.99/mo
Get started →1st Optimal vs One80Rx: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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