10rx vs SkyRx
An in-depth comparison of two leading GLP-1 Providers
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10rx
Best for: budget-focused patients who want low-cost compounded GLP-1 with NAD+ and sermorelin add-ons
Visit 10rx →SkyRx
Best for: shoppers wanting all-inclusive compounded semaglutide with supplies included
Visit SkyRx →10rx and SkyRx are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, 10rx starts lower at $99.67/mo versus $199/mo, and 10rx edges ahead overall (7.1 vs 6.7 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
10rx
Compounded; GLP-1 options as low as under $100/mo
Compounded GLP-1 + GIP
SkyRx
199/mo on a 12-month prepaid subscription; includes med, supplies, visit, shipping
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What’s included
10rx
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
SkyRx
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
10rx
7.1/10
SkyRx
6.7/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 10rx | SkyRx |
|---|---|---|
| Starting Price | ✓$99.67/mo | $199/mo |
| Features | ✓8 features | 6 features |
| States Available | Not disclosed | Not disclosed |
| Compounded | — | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 10rx
10rx is a nationwide GLP-1 telehealth program offering compounded weight-loss medication at low flat monthly rates: semaglutide at $99.67/month and tirzepatide at $149.67/month, with NAD+ and sermorelin also offered for energy and recovery. You take a free online health quiz, a board-certified telehealth doctor reviews your history and prescribes if appropriate, and licensed pharmacy partners ship discreetly. 10rx says it ships to all 50 states, but it doesn't publish its operating company, name its pharmacies, or post a terms page.
Read our full 10rx review →About SkyRx
SkyRx (sky-rx.co) is a US telehealth weight-loss program offering compounded semaglutide as an injection or oral drops, with compounded tirzepatide listed as coming soon. Pricing starts at 199 dollars per month on a 12-month subscription paid upfront, and the single monthly price bundles medication, supplies, doctor visit and shipping with no insurance needed. Medication is dispensed by FDA-registered 503B compounding pharmacies. GLP-1s are not yet available in all 50 states. Support is by phone at 855-759-7979 and email; the company is based in Draper, Utah.
Read our full SkyRx review →Pros & Cons
10rx
What we like
- Very low pricing — compounded semaglutide $99.67/month and tirzepatide $149.67/month
- Free online health quiz with board-certified telehealth doctors reviewing eligibility
- Offers NAD+ and sermorelin alongside GLP-1, for energy and muscle recovery
- Says it ships to all 50 states with discreet delivery from licensed pharmacy partners
Watch-outs
- Doesn't publish its legal operating entity, so accountability is hard to verify
- Pharmacy partners are described as licensed but none are named
- No terms-of-service page is posted, and FAQ answers load only via script
- Compounded semaglutide and tirzepatide only — no brand-name or oral options
- No LegitScript or third-party accreditation is shown on the site
SkyRx
What we like
- All-inclusive 199 dollars per month covers medication, supplies, doctor visit and shipping
- Offers both injectable and oral semaglutide, dispensed by FDA-registered 503B pharmacies
- Same-day shipping for orders before 2pm ET in temperature-controlled packaging
Watch-outs
- 199 dollars pricing requires a 12-month subscription paid upfront
- Tirzepatide only listed as coming soon
- GLP-1s not yet available in all 50 states; specific states not listed
Our Verdict
10rx edges out SkyRx with a higher overall score of 7.1/10 and is particularly strong for budget-focused patients who want low-cost compounded GLP-1 with NAD+ and sermorelin add-ons. SkyRx remains a solid alternative, especially if you're looking for shoppers wanting all-inclusive compounded semaglutide with supplies included.
Choose 10rx if…
You want budget-focused patients who want low-cost compounded GLP-1 with NAD+ and sermorelin add-ons and a starting price around $99.67/mo.
Choose SkyRx if…
You want shoppers wanting all-inclusive compounded semaglutide with supplies included and a starting price around $199/mo.
Ready to start? Vetted GLP-1 providers
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Try Ageless
Lowest-tier compounded GLP-1 in injection, troche and sublingual forms
From $119/mo
Get started →Sunlight
Compounded GLP-1 with unlimited telehealth visits and free shipping
From $159/mo
Get started →MadeMed
Compounded GLP-1 in both injection and oral forms
From $219/mo
Get started →10rx vs SkyRx: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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