10rx vs Onyx Weight Loss
An in-depth comparison of two leading GLP-1 Providers
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Onyx Weight Loss
Best for: NP-led GLP-1 telehealth in 8 states; sema $228/mo or tirz $280/mo, all-in
Visit Onyx Weight Loss →10rx and Onyx Weight Loss are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, 10rx starts lower at $96.67/mo versus $99/mo, and 10rx edges ahead overall (7.1 vs 6.2 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
10rx
Onyx Weight Loss
Verbatim: 'Starting at $228/month' (GLP-1 Agonist plan). Includes medication and supplies shipped to home. Entry tier only; higher-dose pricing not disclosed.
Verbatim: 'Starting at $280/month' (GLP-1/GIP Agonist plan). Includes medication and supplies. Entry tier only; specific drug name inferred from GLP-1/GIP dual agonist designation.
Verbatim: '$99/MONTH' (GLP-1 Microdosing plan). Low-dose gradual-start option.
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What’s included
10rx
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Onyx Weight Loss
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
10rx
7.1/10
Onyx Weight Loss
6.2/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 10rx | Onyx Weight Loss |
|---|---|---|
| Starting Price | ✓$96.67/mo | $99/mo |
| Features | 8 features | 8 features |
| States Available | Not disclosed | 8 |
| Compounded | — | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 10rx
10rx is a nationwide GLP-1 telehealth program offering compounded weight-loss medication at low flat monthly rates: semaglutide at $99.67/month and tirzepatide at $149.67/month, with NAD+ and sermorelin also offered for energy and recovery. You take a free online health quiz, a board-certified telehealth doctor reviews your history and prescribes if appropriate, and licensed pharmacy partners ship discreetly. 10rx says it ships to all 50 states, but it doesn't publish its operating company, name its pharmacies, or post a terms page.
Read our full 10rx review →About Onyx Weight Loss
Onyx Weight Loss is a nurse-practitioner-led telehealth clinic based in Mooresville, NC, offering GLP-1 and GLP-1/GIP weight-loss medications alongside peptides and HRT across 8 states. Founded by Tasha Vangile FNP-C and Madalyn Vangile RN, plans start at $228/month for GLP-1 (semaglutide-type) and $280/month for GLP-1/GIP (tirzepatide-type), with medication and supplies shipped home via Strive Pharmacy partner. A $99/month GLP-1 microdosing option is also available for a gradual-titration start.
Read our full Onyx Weight Loss review →Pros & Cons
10rx
What we like
- Very low pricing — compounded semaglutide $99.67/month and tirzepatide $149.67/month
- Free online health quiz with board-certified telehealth doctors reviewing eligibility
- Offers NAD+ and sermorelin alongside GLP-1, for energy and muscle recovery
- Says it ships to all 50 states with discreet delivery from licensed pharmacy partners
Watch-outs
- Doesn't publish its legal operating entity, so accountability is hard to verify
- Pharmacy partners are described as licensed but none are named
- No terms-of-service page is posted, and FAQ answers load only via script
- Compounded semaglutide and tirzepatide only — no brand-name or oral options
- No LegitScript or third-party accreditation is shown on the site
Onyx Weight Loss
What we like
- Competitive entry pricing: semaglutide from $228/mo and tirzepatide from $280/mo with medication + supplies included
- Nurse-practitioner-led care: founder Tasha Vangile FNP-C (20+ years) and Stephanie Robison APRN-CNP (27 years experience)
- Low-cost $99/mo GLP-1 microdosing option for patients who prefer a gradual titration start
- Strive Pharmacy partnership implies compounded 503A-quality supply chain from a known pharmacy
- Multi-modal clinic: GLP-1 + peptides + HRT + nutrition coaching available under one provider team
Watch-outs
- Only 8 states (NC, CO, ME, VT, VA, IA, NH, PA) — excludes the majority of the US
- No LegitScript certification; credentialing evidence limited to local 2025 Best of Iredell award
- Specific drug names (semaglutide/tirzepatide) never stated on website; compounded status inferred, not disclosed
- Labs not included or mentioned; no baseline bloodwork protocol published
- Pricing shown as 'Starting at' with no dose-escalation tier pricing disclosed publicly
Our Verdict
10rx edges out Onyx Weight Loss with a higher overall score of 7.1/10 and is particularly strong for low-cost compounded GLP-1 with NAD+ and sermorelin add-ons. Onyx Weight Loss remains a solid alternative, especially if you're looking for NP-led GLP-1 telehealth in 8 states; sema $228/mo or tirz $280/mo, all-in.
Choose 10rx if…
You want low-cost compounded GLP-1 with NAD+ and sermorelin add-ons and a starting price around $96.67/mo.
Choose Onyx Weight Loss if…
You want NP-led GLP-1 telehealth in 8 states; sema $228/mo or tirz $280/mo, all-in and a starting price around $99/mo.
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Sunlight
Compounded GLP-1 with unlimited telehealth visits and free shipping
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Men seeking no-fee GLP-1 access with oral and injectable options
From $175/mo
Get started →Oak
Compounded semaglutide and tirzepatide at a flat monthly price
From $133/mo
Get started →10rx vs Onyx Weight Loss: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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