10rx vs Direct Meds
An in-depth comparison of two leading GLP-1 Providers
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10rx
Best for: budget-focused patients who want low-cost compounded GLP-1 with NAD+ and sermorelin add-ons
Visit 10rx →
Direct Meds
Best for: listed for transparent disclosure — see FDA warning and BBB complaint pattern before considering
Visit Direct Meds →10rx and Direct Meds are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, 10rx starts lower at $99.67/mo versus $249/mo, and Direct Meds is the option we'd start with for most patients. Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
10rx
Compounded; GLP-1 options as low as under $100/mo
Compounded GLP-1 + GIP
Direct Meds
Portal shows 'As low as $249.00'; inline JSON minMonthly $237 at some dosages; 90-day supply flow (SEMAGLUTIDE_SUB_90_MONTHLY). Unchanged vs our data.
'As low as $297.00 or $9.58 per day'; flow code INT_MTH_084D_3PK (84-day 3-pack billed monthly). Unchanged vs our data.
CHANGED: was $399 in providers.json, now 'As low as $299.00 or $9.65 per day' (TIRZEPATIDE_SUB_90_MONTHLY_3MG_DAY).
'As low as $399.00 or $12.87 per day'; the '$9.58 per day' string on the public /products/tirzepatide marketing page is a copy error (matches sema math). Unchanged vs our data.
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What’s included
10rx
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Direct Meds
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
10rx
7.1/10
Direct Meds
6.4/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 10rx | Direct Meds |
|---|---|---|
| Starting Price | ✓$99.67/mo | $249/mo |
| Features | ✓8 features | 5 features |
| States Available | Not disclosed | Not disclosed |
| Compounded | — | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | ✓None | 1 warning |
About 10rx
10rx is a nationwide GLP-1 telehealth program offering compounded weight-loss medication at low flat monthly rates: semaglutide at $99.67/month and tirzepatide at $149.67/month, with NAD+ and sermorelin also offered for energy and recovery. You take a free online health quiz, a board-certified telehealth doctor reviews your history and prescribes if appropriate, and licensed pharmacy partners ship discreetly. 10rx says it ships to all 50 states, but it doesn't publish its operating company, name its pharmacies, or post a terms page.
Read our full 10rx review →About Direct Meds
Direct Meds is a Utah-based telehealth provider offering compounded semaglutide and tirzepatide in injection and sublingual formats. Listed here with full disclosure of a September 2025 FDA warning letter for misleading marketing, plus a documented pattern of customers reporting unexpected 3-month commitment charges — see warnings and cons before considering.
Read our full Direct Meds review →Pros & Cons
10rx
What we like
- Very low pricing — compounded semaglutide $99.67/month and tirzepatide $149.67/month
- Free online health quiz with board-certified telehealth doctors reviewing eligibility
- Offers NAD+ and sermorelin alongside GLP-1, for energy and muscle recovery
- Says it ships to all 50 states with discreet delivery from licensed pharmacy partners
Watch-outs
- Doesn't publish its legal operating entity, so accountability is hard to verify
- Pharmacy partners are described as licensed but none are named
- No terms-of-service page is posted, and FAQ answers load only via script
- Compounded semaglutide and tirzepatide only — no brand-name or oral options
- No LegitScript or third-party accreditation is shown on the site
Direct Meds
What we like
- Semaglutide and tirzepatide available in both injection and sublingual formats
- All-inclusive pricing covers medication, consultations, supplies, and 1–2 day temperature-controlled shipping
- LegitScript Certified
- Named 503A pharmacy partners: CraftedRx (MO) and ChemistryRx (PA)
Watch-outs
- FDA warning letter (Sept 2025) for marketing compounded GLP-1s as equivalent to FDA-approved drugs
- BBB rating 1.12/5 across 226 reviews citing a hidden 3-month commitment (charges of $940+ when buyers expected 1 month)
- Wide rating gap: Trustpilot 4.6/5 vs BBB 1.12/5 — points to review-solicitation bias or unresolved complaints
- Not available in Mississippi, Louisiana, or California
- Compounded only — no FDA-approved Ozempic, Wegovy, Zepbound, or Mounjaro
- Auto-renews until you cancel by email; complaints report long hold times and retention friction
Our Verdict
Direct Meds is our recommended choice here, particularly for listed for transparent disclosure — see FDA warning and BBB complaint pattern before considering. 10rx is a solid alternative, especially if you want budget-focused patients who want low-cost compounded GLP-1 with NAD+ and sermorelin add-ons — compare the six-dimension breakdown and pricing below to weigh them for your situation.
Choose 10rx if…
You want budget-focused patients who want low-cost compounded GLP-1 with NAD+ and sermorelin add-ons and a starting price around $99.67/mo.
Choose Direct Meds if…
You want listed for transparent disclosure — see FDA warning and BBB complaint pattern before considering and a starting price around $249/mo.
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Direct Meds
Listed for transparent disclosure — see FDA warning and BBB complaint pattern before considering
From $249/mo
Get started →Maximus
Men seeking compounded GLP-1 alongside testosterone optimization
From $199.99/mo
Get started →Sesame Care
Brand-name GLP-1s (Wegovy, Zepbound) at LillyDirect/NovoCare cash prices — no compounding
From $25/mo
Get started →10rx vs Direct Meds: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.