10rx vs Direct Meds
An in-depth comparison of two leading GLP-1 Providers
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10rx
Best for budget-focused patients who want low-cost compounded GLP-1 with NAD+ and sermorelin add-onsStarting at $99.67/mo
Direct Meds
Best for listed for transparent disclosure — see FDA warning and BBB complaint pattern before consideringStarting at $249/mo
Side-by-Side Comparison
| Feature | 10rx | Direct Meds |
|---|---|---|
| Overall Score | ✓7.0/10 | 5.4/10 |
| Starting Price | ✓$99.67/mo | $249/mo |
| Editorial Rating | ✓3.5 ★ /5 | 2.7 ★ /5 |
| Features | ✓8 features | 5 features |
| States Available | 0 | 0 |
| Compounded | — | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | — | — |
| FDA Warnings | ✓None | 1 warning |
Pros & Cons
10rx
What we like
- Very low pricing — compounded semaglutide $99.67/month and tirzepatide $149.67/month
- Free online health quiz with board-certified telehealth doctors reviewing eligibility
- Offers NAD+ and sermorelin alongside GLP-1, for energy and muscle recovery
- Says it ships to all 50 states with discreet delivery from licensed pharmacy partners
Watch-outs
- Doesn't publish its legal operating entity, so accountability is hard to verify
- Pharmacy partners are described as licensed but none are named
- No terms-of-service page is posted, and FAQ answers load only via script
- Compounded semaglutide and tirzepatide only — no brand-name or oral options
- No LegitScript or third-party accreditation is shown on the site
Direct Meds
What we like
- Semaglutide and tirzepatide available in both injection and sublingual formats
- All-inclusive pricing covers medication, consultations, supplies, and 1–2 day temperature-controlled shipping
- LegitScript Certified
- Named 503A pharmacy partners: CraftedRx (MO) and ChemistryRx (PA)
Watch-outs
- FDA warning letter (Sept 2025) for marketing compounded GLP-1s as equivalent to FDA-approved drugs
- BBB rating 1.12/5 across 226 reviews citing a hidden 3-month commitment (charges of $940+ when buyers expected 1 month)
- Wide rating gap: Trustpilot 4.6/5 vs BBB 1.12/5 — points to review-solicitation bias or unresolved complaints
- Not available in Mississippi, Louisiana, or California
- Compounded only — no FDA-approved Ozempic, Wegovy, Zepbound, or Mounjaro
- Auto-renews until you cancel by email; complaints report long hold times and retention friction
Our Verdict
10rx edges out Direct Meds with a higher overall score of 7.0/10 and is particularly strong for budget-focused patients who want low-cost compounded GLP-1 with NAD+ and sermorelin add-ons. Direct Meds remains a solid alternative, especially if you're looking for listed for transparent disclosure — see FDA warning and BBB complaint pattern before considering.
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.