10rx vs Cost Plus Drugs
An in-depth comparison of two leading GLP-1 Providers
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10rx
Best for: budget-focused patients who want low-cost compounded GLP-1 with NAD+ and sermorelin add-ons
Visit 10rx →
Cost Plus Drugs
Best for: the cheapest transparent-pricing brand-name Ozempic channel
Visit Cost Plus Drugs →10rx and Cost Plus Drugs are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, 10rx starts lower at $99.67/mo versus $279/mo, and both land at 7.1/10 overall. Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
10rx
Compounded; GLP-1 options as low as under $100/mo
Compounded GLP-1 + GIP
Cost Plus Drugs
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What’s included
10rx
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Cost Plus Drugs
Inclusions not disclosed.
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
10rx
7.1/10
Cost Plus Drugs
7.1/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | 10rx | Cost Plus Drugs |
|---|---|---|
| Starting Price | ✓$99.67/mo | $279/mo |
| Features | ✓8 features | 5 features |
| States Available | Not disclosed | 50 |
| Compounded | — | — |
| Brand Name | — | ✓ Yes |
| FSA/HSA Accepted | — | — |
| FDA Warnings | None | None |
About 10rx
10rx is a nationwide GLP-1 telehealth program offering compounded weight-loss medication at low flat monthly rates: semaglutide at $99.67/month and tirzepatide at $149.67/month, with NAD+ and sermorelin also offered for energy and recovery. You take a free online health quiz, a board-certified telehealth doctor reviews your history and prescribes if appropriate, and licensed pharmacy partners ship discreetly. 10rx says it ships to all 50 states, but it doesn't publish its operating company, name its pharmacies, or post a terms page.
Read our full 10rx review →About Cost Plus Drugs
Mark Cuban's transparent-pricing online pharmacy. Sells branded Ozempic at the wholesale acquisition cost plus 15% markup plus a flat $5 pharmacy fee — publicly disclosed margin formula. Pharmacy fulfillment only; no telehealth intake. Ships to all 50 states. Distinct from telehealth platforms that route brand-name semaglutide through similar discount channels.
Read our full Cost Plus Drugs review →Pros & Cons
10rx
What we like
- Very low pricing — compounded semaglutide $99.67/month and tirzepatide $149.67/month
- Free online health quiz with board-certified telehealth doctors reviewing eligibility
- Offers NAD+ and sermorelin alongside GLP-1, for energy and muscle recovery
- Says it ships to all 50 states with discreet delivery from licensed pharmacy partners
Watch-outs
- Doesn't publish its legal operating entity, so accountability is hard to verify
- Pharmacy partners are described as licensed but none are named
- No terms-of-service page is posted, and FAQ answers load only via script
- Compounded semaglutide and tirzepatide only — no brand-name or oral options
- No LegitScript or third-party accreditation is shown on the site
Cost Plus Drugs
What we like
- Transparent pricing: wholesale cost + 15% markup + $5 pharmacy fee, the same for everyone
- Around $279/mo for branded Ozempic — well below typical retail list prices
- Mark Cuban's PBM-disrupting pharmacy, praised by Forbes Health, Wired, and KFF Health News
- Ships to all 50 states; genuine FDA-approved Novo Nordisk Ozempic, not compounded
- Partnered with 9amHealth so you can get prescribed and fill at Cost Plus pricing
Watch-outs
- Fulfillment only — no telehealth intake; you need a prescription from an outside clinician
- Ozempic is FDA-indicated for type 2 diabetes, not weight management — weight-loss use is off-label
- Wegovy availability has been spotty — check current stock before assuming it ships
- No compounded semaglutide or tirzepatide — brand only
- No clinical follow-up — side-effect monitoring falls to your prescribing clinician
Our Verdict
Both 10rx and Cost Plus Drugs score equally well overall — the right choice depends on your priorities.
Choose 10rx if…
You want budget-focused patients who want low-cost compounded GLP-1 with NAD+ and sermorelin add-ons and a starting price around $99.67/mo.
Choose Cost Plus Drugs if…
You want the cheapest transparent-pricing brand-name Ozempic channel and a starting price around $279/mo.
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Sesame Care
Brand-name GLP-1s (Wegovy, Zepbound) at LillyDirect/NovoCare cash prices — no compounding
From $25/mo
Get started →Try Ageless
Lowest-tier compounded GLP-1 in injection, troche and sublingual forms
From $119/mo
Get started →Sunlight
Compounded GLP-1 with unlimited telehealth visits and free shipping
From $159/mo
Get started →10rx vs Cost Plus Drugs: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.