Amazon One Medical vs Onyx Weight Loss
In our scoring, Amazon One Medical edges ahead overall (8.5 vs 6.0 out of 10).
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Key differences
- Price
- Amazon One Medical $199/mo for brand-name Wegovy / Ozempic; Onyx Weight Loss $349/mo for compounded semaglutide (different medications, so not compared on price)
- Coverage
- Amazon One Medical 50 states; Onyx Weight Loss 9 states (only Amazon One Medical: Alabama, Alaska, Arizona and 38 more)
- Included
- Amazon One Medical: clinician visits, shipping (not included: medication, labs); Onyx Weight Loss: medication, clinician visits, shipping
Amazon One Medical
Best for brand-name GLP-1s with published per-dose cash prices and Amazon Pharmacy delivery
Brand-name Wegovy / Ozempic
$199
billed every 4 weeks
Our score 8.5/10
Onyx Weight Loss
Best for NP-led GLP-1 care with labs and monthly visits in 9 states; from $349/mo
semaglutide
$349
Our score 6.0/10
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Costs & coverage
Published prices with their terms attached. Yearly figures are modeled from the standing price and billing cadence. A check mark marks the better side, on like-for-like rows only.
Amazon One Medical
Onyx Weight Loss
Price
Semaglutide / month
Not listed
$349/mo
Tirzepatide / month
Not listed
$399/mo
Oral semaglutide / month
Not listed
$399/mo
Oral tirzepatide / month
Not listed
$499/mo
Brand Wegovy / Ozempic / month
$199/mo
billed every 4 weeks
Not listed
Brand Zepbound / Mounjaro / month
$299/mo
billed every 4 weeks
Not listed
Brand Wegovy pill / Rybelsus / month
$149/mo
Not listed
Brand Foundayo / month
$149/mo
Not listed
Coverage
State availability
50 states
9 states
Oral option listed
Yes
Yes
Brand-name access listed
Wegovy / Ozempic, Zepbound / Mounjaro, Wegovy pill / Rybelsus, Foundayo
Not listed
Included in the price
Clinician visits, shipping
Not included: medication, labs
Medication, clinician visits, shipping
Terms & safety
Price shown
Before intake
Before intake
Lab work
Required
Not disclosed
Video visit
Not disclosed
Required
Minimum commitment
Not disclosed
Monthly memberships or prepaid 10-week plans
FDA warning letters
None on record
None on record
Provider facts checked
October 2026
October 2026
Show where they differ by stateHide state lists
Only Amazon One Medical (41 states)
- Alabama
- Alaska
- Arizona
- Arkansas
- California
- Connecticut
- Delaware
- Florida
- Georgia
- Hawaii
- Idaho
- Illinois
- Indiana
- Kansas
- Kentucky
- Louisiana
- Maryland
- Massachusetts
- Michigan
- Minnesota
- Mississippi
- Missouri
- Montana
- Nevada
- New Jersey
- New Mexico
- New York
- North Dakota
- Ohio
- Oklahoma
- Oregon
- Rhode Island
- South Carolina
- South Dakota
- Tennessee
- Texas
- Utah
- Washington
- West Virginia
- Wisconsin
- Wyoming
Every dose and plan: Amazon One Medical · Onyx Weight Loss
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Which fits your priorities?
Only the points where these two differ, from the table above and each provider’s record.
Choose Amazon One Medical if…
- Lists brand-name Wegovy / Ozempic, brand-name Zepbound / Mounjaro and brand-name Wegovy pill / Rybelsus, which Onyx Weight Loss doesn't price
- Serves 41 states that Onyx Weight Loss doesn't
- Publishes cash prices for every GLP-1 dose up front, with manufacturer coupons applied automatically if eligible
What to weigh up
- Price doesn't include medication
- Online On-Demand Care is cash-only for medication; insurance needs scheduled visits near a One Medical office
Choose Onyx Weight Loss if…
- Lists compounded semaglutide, compounded tirzepatide and oral compounded semaglutide, which Amazon One Medical doesn't price
- Price includes medication; Amazon One Medical's doesn't
- One-on-one virtual visits with a named nurse-practitioner team, not just an online form
What to weigh up
- Not available in 41 states that Amazon One Medical serves
- Only 9 states (CO, IA, ME, NE, NH, NC, PA, VT, VA)
Explore the scoring factors
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
Amazon One Medical
8.5/10
Onyx Weight Loss
6.0/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Ready to start? Vetted GLP-1 providers
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From $139/mo
Get started →From $299/mo
Get started →SkinnyRx
Compounded semaglutide or tirzepatide with the consult and free overnight shipping in one price
Read full review →From $149.25/mo
Get started →Amazon One Medical vs Onyx Weight Loss: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Or see the full category ranking.
Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.