TotalRx vs Vytora Health
In our scoring, Vytora Health edges ahead overall (8.4 vs 7.4 out of 10), and Vytora Health costs less for compounded semaglutide (about $439 a year less; one bills every 4 weeks (13 charges a year), so this compares modeled yearly cost).
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Key differences
- Price
- Vytora Health $179/mo vs TotalRx $199/mo for compounded semaglutide (standing prices, no prepay or separate membership listed · about $439 a year less with Vytora Health · one bills every 4 weeks (13 charges a year), so this compares modeled yearly cost)
- Coverage
- Vytora Health 50 states + DC (TotalRx doesn't publish a state list)
- Included
- TotalRx: medication, clinician visits, shipping; Vytora Health: medication, clinician visits, shipping
TotalRx
Accepts FSA/HSA cards
semaglutide
$199
billed every 4 weeks
Our score 7.4/10
Vytora Health
Best for compounded or brand-name GLP-1 with named pharmacy partners, 50 states
semaglutide
$179
Our score 8.4/10
We may earn a commission if you sign up through these links. Partner status can affect which provider we feature; it never changes a score or a price.
Costs & coverage
Published prices with their terms attached. Yearly figures are modeled from the standing price and billing cadence. A check mark marks the better side, on like-for-like rows only.
TotalRx
Vytora Health
Price
Semaglutide / month
$199/mo
billed every 4 weeks
Better on this row: $179/mo
Semaglutide / year (modeled)
$2,587
13 charges
Better on this row: $2,148
Tirzepatide / month
$249/mo
billed every 4 weeks
Better on this row: $249/mo
Tirzepatide / year (modeled)
$3,237
13 charges
Better on this row: $2,988
Brand Zepbound / Mounjaro / month
Not listed
$1,399/mo
Coverage
State availability
List not published
50 states + DC
Brand-name access listed
Not listed
Zepbound / Mounjaro
Included in the price
Medication, clinician visits, shipping
Medication, clinician visits, shipping
FSA/HSA accepted
Yes
Not listed
Terms & safety
Price shown
Before intake
Before intake
Cancel anytime
Yes
Yes
Minimum commitment
None on the monthly plan; 3-, 6- and 12-month prepaid plans are offered
None on monthly plans; 3-month plans are billed every 3 months
Refunds
Full refund if medically disqualified; otherwise no refund on cancellation, except a pro-rata refund for unshipped medication on prepaid multi-month plans
'All sales are final' for prescription products; refund requests 'reviewed on a case-by-case basis'
Early-cancellation fee
None
Not disclosed
FDA warning letters
None on record
None on record
Provider facts checked
October 2026
October 2026
Every dose and plan: TotalRx · Vytora Health
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Which fits your priorities?
Only the points where these two differ, from the table above and each provider’s record.
Choose TotalRx if…
- Accepts FSA/HSA cards
- Names all four dispensing pharmacies in its terms, with addresses and phone numbers
- Names its clinical network: OpenLoop Healthcare Partners PC
What to weigh up
- About $439 a year more than Vytora Health for compounded semaglutide (one bills every 4 weeks (13 charges a year), so this compares modeled yearly cost)
- No published state list; confirm yours at signup
Choose Vytora Health if…
- About $439 a year less than TotalRx for compounded semaglutide at standing prices (one bills every 4 weeks (13 charges a year), so this compares modeled yearly cost)
- Lists brand-name Zepbound / Mounjaro, which TotalRx doesn't price
- Publishes its full state list (50 states + DC)
What to weigh up
- Brand-name Mounjaro and Zepbound at $1,399/mo are priced at retail; manufacturer self-pay programs are often cheaper
- Compounded tirzepatide at $249/mo month-to-month is mid-market
Explore the scoring factors
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
TotalRx
7.4/10
Vytora Health
8.4/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
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Ivim Health
Compounded GLP-1 with weekly provider check-ins and health coaches, under a required monthly membership
Read full review →From $65/mo + membership
Get started →From $247/mo
Get started →From $139/mo
Get started →TotalRx vs Vytora Health: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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Wegovy®, Ozempic®, and Rybelsus® are trademarks of Novo Nordisk A/S. Mounjaro® and Zepbound® are trademarks of Eli Lilly and Company. All other product names and trademarks referenced on this page belong to their respective owners. WeightLossRankings.org is not affiliated with any pharmaceutical manufacturer. See trademark disclaimer.