The Protocole vs NewSelf
An in-depth comparison of two leading GLP-1 Providers
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The Protocole
Best for: people who want compounded semaglutide or tirzepatide alongside other peptide therapies in one place
Visit The Protocole →
NewSelf
Best for: lowest-cost compounded GLP-1 with pharmacy quality transparency
Visit NewSelf →The Protocole and NewSelf are both GLP-1 Providers competing for the same patients, but they make different trade-offs on price, coverage, and what's included. In our scoring, NewSelf starts lower at $100/mo versus $249/mo, and NewSelf edges ahead overall (8.3 vs 7.0 out of 10). Below we break down pricing, what each plan covers, the six-dimension score, pros and cons, and exactly who should pick which.
Pricing
The Protocole
One-time 4-week supply $279 with no renewal; quarterly plan $699 every 3 months (about $233 a month)
One-time 4-week supply $329 with no renewal; quarterly plan $799 every 3 months (about $266 a month)
NewSelf
All dosages same price
All dosages same price
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What’s included
The Protocole
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
NewSelf
What the monthly price covers
Medication
Included
Provider visits
Included
Shipping
Included
Lab work
Not disclosed
Coaching
Not disclosed
Score breakdown
Both providers are scored on the same six-dimension framework. The gradient bar marks the stronger side on each dimension.
The Protocole
7.0/10
NewSelf
8.3/10
Value25%
Effectiveness25%
User Experience15%
Trust & Safety15%
Accessibility10%
Support10%
Features & Coverage
| Feature | The Protocole | NewSelf |
|---|---|---|
| Starting Price | $249/mo | ✓$100/mo |
| Features | ✓7 features | 6 features |
| States Available | Not disclosed | 49 |
| Compounded | ✓ Yes | ✓ Yes |
| Brand Name | — | — |
| FSA/HSA Accepted | ✓ Yes | — |
| FDA Warnings | ✓None | 1 warning |
About The Protocole
The Protocole is a New York peptide therapy platform that also sells compounded semaglutide and tirzepatide, prescribed by clinicians at Arora Health & Aesthetics and dispensed by VialsRX. Monthly plans cost $249 for semaglutide and $299 for tirzepatide, and a single 4-week supply with no renewal costs $279 or $329. The price includes provider review and free shipping.
Read our full The Protocole review →About NewSelf
NewSelf offers compounded semaglutide+ (with B12/Glycine, from $99.97/mo) and compounded tirzepatide+ (with B6/Glycine, from $144.49/mo). LegitScript certified. Available in 48 states + Puerto Rico. Uses 503A licensed pharmacies with third-party testing.
Read our full NewSelf review →Pros & Cons
The Protocole
What we like
- Names its medical group, Arora Health & Aesthetics, and its dispensing pharmacy, VialsRX
- A one-time 4-week supply is sold with no renewal, at $279 for semaglutide or $329 for tirzepatide
- Monthly plans cost less, $249 for semaglutide and $299 for tirzepatide, with free shipping
- You get a full refund if the clinician does not approve treatment
- You can pause or cancel a monthly plan before the next billing date
- An optional 45-minute video consultation costs $85, deducted from your order if you go ahead
- FSA and HSA cards are accepted
Watch-outs
- The lower monthly plan prices appear only at checkout; the website lists the higher one-time prices
- You must create a password-protected account before the first question
- Checkout charges your card before a clinician reviews you, though the FAQ says you pay after approval
- Orders become final once clinical review or fulfillment starts, and shipping fees are not refunded
- The terms describe a membership fee and no subscriptions, which does not match the checkout
- The one-time checkout says there are no recurring charges but also shows auto-renewal wording
- Its Trustpilot profile is unclaimed and has a single review
- Disputes go to binding individual arbitration under New York law
NewSelf
What we like
- Semaglutide+ from $99.97/mo — among the lowest prices in the dataset
- All dosages at the same price — no price escalation as dose increases
- LegitScript certified with 503A licensed pharmacies
- Third-party potency, sterility, and endotoxicity testing
- 48 states + Puerto Rico coverage
- B12/B6 + Glycine enhanced formulations
- No membership fees
Watch-outs
- Not available in Mississippi and Louisiana
- Compounded only — no brand-name options
- Site also promotes AI health optimization and longevity (broader platform)
Our Verdict
NewSelf edges out The Protocole with a higher overall score of 8.3/10 and is particularly strong for lowest-cost compounded GLP-1 with pharmacy quality transparency. The Protocole remains a solid alternative, especially if you're looking for people who want compounded semaglutide or tirzepatide alongside other peptide therapies in one place.
Choose The Protocole if…
You want people who want compounded semaglutide or tirzepatide alongside other peptide therapies in one place and a starting price around $249/mo.
Choose NewSelf if…
You want lowest-cost compounded GLP-1 with pharmacy quality transparency and a starting price around $100/mo.
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Direct Meds
Listed for disclosure only — see its FDA warning and BBB complaints first
From $249/mo
Get started →Maximus
Men seeking compounded GLP-1 alongside testosterone optimization
From $199.99/mo
Get started →Sesame Care
Brand-name GLP-1s at cash prices, no compounding
From $25/mo
Get started →The Protocole vs NewSelf: FAQ
Key terms, explained
New to GLP-1s? Tap any term for a quick, plain-English definition.
- Semaglutide · Drugs and brands
- Tirzepatide · Drugs and brands
- Compounded GLP-1 · Pharmacy and drug forms
- 503A pharmacy · Pharmacy and drug forms
- PCAB accreditation · Pharmacy and drug forms
- Prior authorization (PA) · Insurance and regulatory
- Off-label use · Insurance and regulatory
- FDA Drug Shortage List · Insurance and regulatory
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